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Cell-cell and virus-cell fusion assay-based analyses of alanine insertion mutants in the distal α9 portion of the JRFL gp41 subunit from HIV-1.

Yamamoto M, Du Q, Song J, Wang H, Watanabe A, Tanaka Y, Kawaguchi Y, Inoue JI, Matsuda Z.

J Biol Chem. 2019 Apr 5;294(14):5677-5687. doi: 10.1074/jbc.RA118.004579. Epub 2019 Feb 8.


Six-helix bundle completion in the distal C-terminal heptad repeat region of gp41 is required for efficient human immunodeficiency virus type 1 infection.

Liu D, Wang H, Yamamoto M, Song J, Zhang R, Du Q, Kawaguchi Y, Inoue JI, Matsuda Z.

Retrovirology. 2018 Apr 2;15(1):27. doi: 10.1186/s12977-018-0410-9.


Stabilizing the native trimer of HIV-1 Env by destabilizing the heterodimeric interface of the gp41 postfusion six-helix bundle.

Kesavardhana S, Varadarajan R.

J Virol. 2014 Sep 1;88(17):9590-604. doi: 10.1128/JVI.00494-14. Epub 2014 Jun 11.


The membrane proximal external regions of gp41 from HIV-1 strains HXB2 and JRFL have different sensitivities to alanine mutation.

Yi HA, Diaz-Rohrer B, Saminathan P, Jacobs A.

Biochemistry. 2015 Mar 3;54(8):1681-93. doi: 10.1021/bi501171r. Epub 2015 Feb 19.


Conserved salt bridge between the N- and C-terminal heptad repeat regions of the human immunodeficiency virus type 1 gp41 core structure is critical for virus entry and inhibition.

He Y, Liu S, Li J, Lu H, Qi Z, Liu Z, Debnath AK, Jiang S.

J Virol. 2008 Nov;82(22):11129-39. doi: 10.1128/JVI.01060-08. Epub 2008 Sep 3.


Significant differences in cell-cell fusion and viral entry between strains revealed by scanning mutagenesis of the C-heptad repeat of HIV gp41.

Diaz-Aguilar B, Dewispelaere K, Yi HA, Jacobs A.

Biochemistry. 2013 May 21;52(20):3552-63. doi: 10.1021/bi400201h. Epub 2013 May 7.


The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein.

Miyauchi K, Curran AR, Long Y, Kondo N, Iwamoto A, Engelman DM, Matsuda Z.

Retrovirology. 2010 Nov 13;7:95. doi: 10.1186/1742-4690-7-95.


Conserved arginine residue in the membrane-spanning domain of HIV-1 gp41 is required for efficient membrane fusion.

Long Y, Meng F, Kondo N, Iwamoto A, Matsuda Z.

Protein Cell. 2011 May;2(5):369-76. doi: 10.1007/s13238-011-1051-0. Epub 2011 Jun 12.


Identification of the LWYIK motif located in the human immunodeficiency virus type 1 transmembrane gp41 protein as a distinct determinant for viral infection.

Chen SS, Yang P, Ke PY, Li HF, Chan WE, Chang DK, Chuang CK, Tsai Y, Huang SC.

J Virol. 2009 Jan;83(2):870-83. doi: 10.1128/JVI.01088-08. Epub 2008 Nov 5.


Conserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors.

Geng X, Liu Z, Yu D, Qin B, Zhu Y, Cui S, Chong H, He Y.

Viruses. 2019 Jul 3;11(7). pii: E609. doi: 10.3390/v11070609.


Regulation of human immunodeficiency virus type 1 envelope glycoprotein fusion by a membrane-interactive domain in the gp41 cytoplasmic tail.

Wyss S, Dimitrov AS, Baribaud F, Edwards TG, Blumenthal R, Hoxie JA.

J Virol. 2005 Oct;79(19):12231-41.


The conserved residue Arg46 in the N-terminal heptad repeat domain of HIV-1 gp41 is critical for viral fusion and entry.

Wang X, Xiong W, Ma X, Wei M, Chen Y, Lu L, Debnath AK, Jiang S, Pan C.

PLoS One. 2012;7(9):e44874. doi: 10.1371/journal.pone.0044874. Epub 2012 Sep 7.


HIV-1 gp41 Residues Modulate CD4-Induced Conformational Changes in the Envelope Glycoprotein and Evolution of a Relaxed Conformation of gp120.

Keller PW, Morrison O, Vassell R, Weiss CD.

J Virol. 2018 Jul 31;92(16). pii: e00583-18. doi: 10.1128/JVI.00583-18. Print 2018 Aug 15.


Synergistic inhibition of HIV-1 envelope-mediated membrane fusion by inhibitors targeting the N and C-terminal heptad repeats of gp41.

Gustchina E, Louis JM, Bewley CA, Clore GM.

J Mol Biol. 2006 Dec 1;364(3):283-9. Epub 2006 Sep 12.


Role of the fusion peptide and membrane-proximal domain in HIV-1 envelope glycoprotein-mediated membrane fusion.

Dimitrov AS, Rawat SS, Jiang S, Blumenthal R.

Biochemistry. 2003 Dec 9;42(48):14150-8.


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