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Results by year

Year	Number of Results
2008	1
2009	2
2010	2
2011	2
2012	7
2013	7
2014	9
2015	22
2016	30
2017	52
2018	66
2019	124
2020	198
2021	173
2022	132
2023	43
2024	0

772 results

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Immune-Checkpoint Blockade Opposes CD8⁺ T-cell Suppression in Human and Murine Cancer.

Pfannenstiel LW, Diaz-Montero CM, Tian YF, Scharpf J, Ko JS, Gastman BR. Pfannenstiel LW, et al. Cancer Immunol Res. 2019 Mar;7(3):510-525. doi: 10.1158/2326-6066.CIR-18-0054. Epub 2019 Feb 6. Cancer Immunol Res. 2019. PMID: 30728151 Free PMC article.

Targeting PD-1 and Tim-3 Pathways to Reverse CD8 T-Cell Exhaustion and Enhance Ex Vivo T-Cell Responses to Autologous Dendritic/Tumor Vaccines.

Liu J, Zhang S, Hu Y, Yang Z, Li J, Liu X, Deng L, Wang Y, Zhang X, Jiang T, Lu X. Liu J, et al. J Immunother. 2016 May;39(4):171-80. doi: 10.1097/CJI.0000000000000122. J Immunother. 2016. PMID: 27070448

Increased PD-1⁺ and TIM-3⁺ TILs during Cetuximab Therapy Inversely Correlate with Response in Head and Neck Cancer Patients.

Jie HB, Srivastava RM, Argiris A, Bauman JE, Kane LP, Ferris RL. Jie HB, et al. Cancer Immunol Res. 2017 May;5(5):408-416. doi: 10.1158/2326-6066.CIR-16-0333. Epub 2017 Apr 13. Cancer Immunol Res. 2017. PMID: 28408386 Free PMC article. Clinical Trial.

Novel Effector Phenotype of Tim-3⁺ Regulatory T Cells Leads to Enhanced Suppressive Function in Head and Neck Cancer Patients.

Liu Z, McMichael EL, Shayan G, Li J, Chen K, Srivastava R, Kane LP, Lu B, Ferris RL. Liu Z, et al. Clin Cancer Res. 2018 Sep 15;24(18):4529-4538. doi: 10.1158/1078-0432.CCR-17-1350. Epub 2018 Apr 30. Clin Cancer Res. 2018. PMID: 29712685 Free PMC article.

Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas.

Zhou G, Sprengers D, Boor PPC, Doukas M, Schutz H, Mancham S, Pedroza-Gonzalez A, Polak WG, de Jonge J, Gaspersz M, Dong H, Thielemans K, Pan Q, IJzermans JNM, Bruno MJ, Kwekkeboom J. Zhou G, et al. Gastroenterology. 2017 Oct;153(4):1107-1119.e10. doi: 10.1053/j.gastro.2017.06.017. Epub 2017 Jun 23. Gastroenterology. 2017. PMID: 28648905

Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1^-CD8⁺ Tumor-Infiltrating T Cells.

Kurtulus S, Madi A, Escobar G, Klapholz M, Nyman J, Christian E, Pawlak M, Dionne D, Xia J, Rozenblatt-Rosen O, Kuchroo VK, Regev A, Anderson AC. Kurtulus S, et al. Immunity. 2019 Jan 15;50(1):181-194.e6. doi: 10.1016/j.immuni.2018.11.014. Epub 2019 Jan 8. Immunity. 2019. PMID: 30635236 Free PMC article.

Autocrine Complement Inhibits IL10-Dependent T-cell-Mediated Antitumor Immunity to Promote Tumor Progression.

Wang Y, Sun SN, Liu Q, Yu YY, Guo J, Wang K, Xing BC, Zheng QF, Campa MJ, Patz EF Jr, Li SY, He YW. Wang Y, et al. Cancer Discov. 2016 Sep;6(9):1022-35. doi: 10.1158/2159-8290.CD-15-1412. Epub 2016 Jun 13. Cancer Discov. 2016. PMID: 27297552 Free PMC article.

Blocking Tim-3 or/and PD-1 reverses dysfunction of tumor-infiltrating lymphocytes in HBV-related hepatocellular carcinoma.

Liu F, Zeng G, Zhou S, He X, Sun N, Zhu X, Hu A. Liu F, et al. Bull Cancer. 2018 May;105(5):493-501. doi: 10.1016/j.bulcan.2018.01.018. Epub 2018 Mar 22. Bull Cancer. 2018. PMID: 29576222

Characterization of tumor-associated T-lymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma.

Lechner A, Schlößer H, Rothschild SI, Thelen M, Reuter S, Zentis P, Shimabukuro-Vornhagen A, Theurich S, Wennhold K, Garcia-Marquez M, Tharun L, Quaas A, Schauss A, Isensee J, Hucho T, Huebbers C, von Bergwelt-Baildon M, Beutner D. Lechner A, et al. Oncotarget. 2017 Jul 4;8(27):44418-44433. doi: 10.18632/oncotarget.17901. Oncotarget. 2017. PMID: 28574843 Free PMC article.

TOX-expressing terminally exhausted tumor-infiltrating CD8⁺ T cells are reinvigorated by co-blockade of PD-1 and TIGIT in bladder cancer.

Han HS, Jeong S, Kim H, Kim HD, Kim AR, Kwon M, Park SH, Woo CG, Kim HK, Lee KH, Seo SP, Kang HW, Kim WT, Kim WJ, Yun SJ, Shin EC. Han HS, et al. Cancer Lett. 2021 Feb 28;499:137-147. doi: 10.1016/j.canlet.2020.11.035. Epub 2020 Nov 27. Cancer Lett. 2021. PMID: 33249194

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