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Items: 1 to 20 of 102

1.

Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice.

Leggiero E, Labruna G, Iaffaldano L, Lombardo B, Greco A, Fiorenza D, Gramanzini M, Montanaro D, Baldi A, Cerullo V, Sacchetti L, Pastore L.

Gene Ther. 2019 Apr;26(3-4):121-130. doi: 10.1038/s41434-019-0061-z. Epub 2019 Jan 30.

PMID:
30700805
2.

Long-term stable correction of low-density lipoprotein receptor-deficient mice with a helper-dependent adenoviral vector expressing the very low-density lipoprotein receptor.

Oka K, Pastore L, Kim IH, Merched A, Nomura S, Lee HJ, Merched-Sauvage M, Arden-Riley C, Lee B, Finegold M, Beaudet A, Chan L.

Circulation. 2001 Mar 6;103(9):1274-81.

PMID:
11238273
5.

PEGylated helper-dependent adenoviral vector expressing human Apo A-I for gene therapy in LDLR-deficient mice.

Leggiero E, Astone D, Cerullo V, Lombardo B, Mazzaccara C, Labruna G, Sacchetti L, Salvatore F, Croyle M, Pastore L.

Gene Ther. 2013 Dec;20(12):1124-30. doi: 10.1038/gt.2013.38. Epub 2013 Jul 25. Erratum in: Gene Ther. 2013 Dec;20(12):1192.

PMID:
23883962
6.

Low-density lipoprotein (LDL) receptor/transferrin fusion protein: in vivo production and functional evaluation as a potential therapeutic tool for lowering plasma LDL cholesterol.

Razzini G, Parise F, Calebiro D, Battini R, Bagni B, Corazzari T, Tarugi P, Angelelli C, Molinari S, Falqui L, Ferrari S.

Hum Gene Ther. 2004 Jun;15(6):533-41.

PMID:
15212712
7.

Sleeping Beauty Transposon Vectors in Liver-directed Gene Delivery of LDLR and VLDLR for Gene Therapy of Familial Hypercholesterolemia.

Turunen TA, Kurkipuro J, Heikura T, Vuorio T, Hytönen E, Izsvák Z, Ylä-Herttuala S.

Mol Ther. 2016 Mar;24(3):620-35. doi: 10.1038/mt.2015.221. Epub 2015 Dec 16.

8.
9.

Gene therapy for rhesus monkeys heterozygous for LDL receptor deficiency by balloon catheter hepatic delivery of helper-dependent adenoviral vector.

Oka K, Mullins CE, Kushwaha RS, Leen AM, Chan L.

Gene Ther. 2015 Jan;22(1):87-95. doi: 10.1038/gt.2014.85. Epub 2014 Sep 18.

10.

Bempedoic Acid Lowers Low-Density Lipoprotein Cholesterol and Attenuates Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR+/- and LDLR-/-) Yucatan Miniature Pigs.

Burke AC, Telford DE, Sutherland BG, Edwards JY, Sawyez CG, Barrett PHR, Newton RS, Pickering JG, Huff MW.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):1178-1190. doi: 10.1161/ATVBAHA.117.310676. Epub 2018 Feb 15.

11.

Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice.

Willecke F, Yuan C, Oka K, Chan L, Hu Y, Barnhart S, Bornfeldt KE, Goldberg IJ, Fisher EA.

PLoS One. 2015 Jun 5;10(6):e0128996. doi: 10.1371/journal.pone.0128996. eCollection 2015.

12.

Gene therapy for familial hypercholesterolemia.

Van Craeyveld E, Jacobs F, Gordts SC, De Geest B.

Curr Pharm Des. 2011;17(24):2575-91. Review.

PMID:
21774774
13.

Adenovirus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor (SR-AI) in LDL receptor knock-out mice.

Jalkanen J, Leppänen P, Närvänen O, Greaves DR, Ylä-Herttuala S.

Atherosclerosis. 2003 Jul;169(1):95-103.

PMID:
12860255
14.

Regression and stabilization of advanced murine atherosclerotic lesions: a comparison of LDL lowering and HDL raising gene transfer strategies.

Van Craeyveld E, Gordts SC, Nefyodova E, Jacobs F, De Geest B.

J Mol Med (Berl). 2011 Jun;89(6):555-67. doi: 10.1007/s00109-011-0722-x. Epub 2011 Jan 21.

15.

Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor.

Kobayashi K, Oka K, Forte T, Ishida B, Teng B, Ishimura-Oka K, Nakamuta M, Chan L.

J Biol Chem. 1996 Mar 22;271(12):6852-60.

16.

LDL Receptor Gene-ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia With Dominant Inheritance and Diet-induced Coronary Atherosclerosis.

Guo X, Gao M, Wang Y, Lin X, Yang L, Cong N, An X, Wang F, Qu K, Yu L, Wang Y, Wang J, Zhu H, Xian X, Liu G.

EBioMedicine. 2018 Jan;27:214-224. doi: 10.1016/j.ebiom.2017.12.013. Epub 2017 Dec 15.

17.

LCAT modulates atherogenic plasma lipoproteins and the extent of atherosclerosis only in the presence of normal LDL receptors in transgenic rabbits.

Brousseau ME, Kauffman RD, Herderick EE, Demosky SJ Jr, Evans W, Marcovina S, Santamarina-Fojo S, Brewer HB Jr, Hoeg JM.

Arterioscler Thromb Vasc Biol. 2000 Feb;20(2):450-8.

PMID:
10669643
18.

Adenoviral low density lipoprotein receptor attenuates progression of atherosclerosis and decreases tissue cholesterol levels in a murine model of familial hypercholesterolemia.

Jacobs F, Van Craeyveld E, Feng Y, Snoeys J, De Geest B.

Atherosclerosis. 2008 Dec;201(2):289-97. doi: 10.1016/j.atherosclerosis.2008.02.023. Epub 2008 Mar 4.

PMID:
18378244
20.

Ces3/TGH deficiency improves dyslipidemia and reduces atherosclerosis in Ldlr(-/-) mice.

Lian J, Quiroga AD, Li L, Lehner R.

Circ Res. 2012 Sep 28;111(8):982-90. Epub 2012 Aug 7.

PMID:
22872154

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