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Items: 1 to 20 of 98

1.

Cholesterol Metabolism: A Potential Therapeutic Target in Glioblastoma.

Ahmad F, Sun Q, Patel D, Stommel JM.

Cancers (Basel). 2019 Jan 26;11(2). pii: E146. doi: 10.3390/cancers11020146. Review.

2.

An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway.

Guo D, Reinitz F, Youssef M, Hong C, Nathanson D, Akhavan D, Kuga D, Amzajerdi AN, Soto H, Zhu S, Babic I, Tanaka K, Dang J, Iwanami A, Gini B, Dejesus J, Lisiero DD, Huang TT, Prins RM, Wen PY, Robins HI, Prados MD, Deangelis LM, Mellinghoff IK, Mehta MP, James CD, Chakravarti A, Cloughesy TF, Tontonoz P, Mischel PS.

Cancer Discov. 2011 Oct;1(5):442-56. doi: 10.1158/2159-8290.CD-11-0102. Epub 2011 Sep 15. Erratum in: Cancer Discov. 2012 Feb;2(2):290-1.

3.

Nuclear receptor LXR as a novel therapeutic antitumoral target in glioblastoma.

Moschetta A.

Cancer Discov. 2011 Oct;1(5):381-2. doi: 10.1158/2159-8290.CD-11-0228.

4.

TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis.

Hsieh J, Koseki M, Molusky MM, Yakushiji E, Ichi I, Westerterp M, Iqbal J, Chan RB, Abramowicz S, Tascau L, Takiguchi S, Yamashita S, Welch CL, Di Paolo G, Hussain MM, Lefkowitch JH, Rader DJ, Tall AR.

Nature. 2016 Jul 14;535(7611):303-7. doi: 10.1038/nature18628. Epub 2016 Jul 6.

5.

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.

Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ.

Genes Dev. 2000 Nov 15;14(22):2819-30.

6.

Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis.

Zhang L, Reue K, Fong LG, Young SG, Tontonoz P.

Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2541-6. doi: 10.1161/ATVBAHA.112.250571. Epub 2012 Aug 30. Review.

7.

Protein phosphatase 2A (PP2A) regulates low density lipoprotein uptake through regulating sterol response element-binding protein-2 (SREBP-2) DNA binding.

Rice LM, Donigan M, Yang M, Liu W, Pandya D, Joseph BK, Sodi V, Gearhart TL, Yip J, Bouchard M, Nickels JT Jr.

J Biol Chem. 2014 Jun 13;289(24):17268-79. doi: 10.1074/jbc.M114.570390. Epub 2014 Apr 26.

8.

27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells.

An Y, Zhang DD, Yu HL, Ma WW, Lu YH, Liu QR, Xiao R.

Neurotoxicology. 2017 Mar;59:88-97. doi: 10.1016/j.neuro.2017.02.001. Epub 2017 Feb 3.

PMID:
28167099
9.

Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis.

Geng F, Cheng X, Wu X, Yoo JY, Cheng C, Guo JY, Mo X, Ru P, Hurwitz B, Kim SH, Otero J, Puduvalli V, Lefai E, Ma J, Nakano I, Horbinski C, Kaur B, Chakravarti A, Guo D.

Clin Cancer Res. 2016 Nov 1;22(21):5337-5348. Epub 2016 Jun 8. Erratum in: Clin Cancer Res. 2017 Apr 15;23 (8):2127.

10.

Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting.

Quinet EM, Savio DA, Halpern AR, Chen L, Schuster GU, Gustafsson JA, Basso MD, Nambi P.

Mol Pharmacol. 2006 Oct;70(4):1340-9. Epub 2006 Jul 6.

PMID:
16825483
11.

Sphingolipid synthetic pathways are major regulators of lipid homeostasis.

Worgall TS.

Adv Exp Med Biol. 2011;721:139-48. doi: 10.1007/978-1-4614-0650-1_9. Review.

PMID:
21910087
12.

Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells.

Panzenboeck U, Kratzer I, Sovic A, Wintersperger A, Bernhart E, Hammer A, Malle E, Sattler W.

Int J Biochem Cell Biol. 2006;38(8):1314-29. Epub 2006 Feb 24.

PMID:
16530456
13.

Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake.

Yang M, Liu W, Pellicane C, Sahyoun C, Joseph BK, Gallo-Ebert C, Donigan M, Pandya D, Giordano C, Bata A, Nickels JT Jr.

J Lipid Res. 2014 Feb;55(2):226-38. doi: 10.1194/jlr.M041335. Epub 2013 Dec 2.

14.

Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter.

Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty AH, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Kimura S, Ishibashi S, Yamada N.

Mol Cell Biol. 2001 May;21(9):2991-3000.

15.

On the regulatory importance of 27-hydroxycholesterol in mouse liver.

Heverin M, Ali Z, Olin M, Tillander V, Joibari MM, Makoveichuk E, Leitersdorf E, Warner M, Olivercrona G, Gustafsson JÅ, Björkhem I.

J Steroid Biochem Mol Biol. 2017 May;169:10-21. doi: 10.1016/j.jsbmb.2016.02.001. Epub 2016 Feb 3.

PMID:
26851362
16.

25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway.

Ma Y, Xu L, Rodriguez-Agudo D, Li X, Heuman DM, Hylemon PB, Pandak WM, Ren S.

Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1369-79. doi: 10.1152/ajpendo.90555.2008. Epub 2008 Oct 14.

17.

Genetic deletion of low density lipoprotein receptor impairs sterol-induced mouse macrophage ABCA1 expression. A new SREBP1-dependent mechanism.

Zhou X, He W, Huang Z, Gotto AM Jr, Hajjar DP, Han J.

J Biol Chem. 2008 Jan 25;283(4):2129-38. Epub 2007 Nov 20.

18.

Targeting SREBP-1-driven lipid metabolism to treat cancer.

Guo D, Bell EH, Mischel P, Chakravarti A.

Curr Pharm Des. 2014;20(15):2619-26. Review.

19.

A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP-2.

Li Y, Song Y, Zhao M, Guo Y, Yu C, Chen W, Shao S, Xu C, Zhou X, Zhao L, Zhang Z, Bo T, Xia Y, Proud CG, Wang X, Wang L, Zhao J, Gao L.

Hepatology. 2017 Aug;66(2):481-497. doi: 10.1002/hep.29206. Epub 2017 Jun 27. Erratum in: Hepatology. 2018 Mar;67(3):1188.

20.

Hepatic overexpression of idol increases circulating protein convertase subtilisin/kexin type 9 in mice and hamsters via dual mechanisms: sterol regulatory element-binding protein 2 and low-density lipoprotein receptor-dependent pathways.

Sasaki M, Terao Y, Ayaori M, Uto-Kondo H, Iizuka M, Yogo M, Hagisawa K, Takiguchi S, Yakushiji E, Nakaya K, Ogura M, Komatsu T, Ikewaki K.

Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1171-8. doi: 10.1161/ATVBAHA.113.302670. Epub 2014 Mar 27.

PMID:
24675665

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