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Items: 1 to 20 of 96

1.

Effects of Reducing Norepinephrine Levels via DSP4 Treatment on Amyloid-β Pathology in Female Rhesus Macaques (Macaca Mulatta).

Duffy KB, Ray B, Lahiri DK, Tilmont EM, Tinkler GP, Herbert RL, Greig NH, Ingram DK, Ottinger MA, Mattison JA.

J Alzheimers Dis. 2019;68(1):115-126. doi: 10.3233/JAD-180487.

PMID:
30689563
2.

Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease.

Heneka MT, Galea E, Gavriluyk V, Dumitrescu-Ozimek L, Daeschner J, O'Banion MK, Weinberg G, Klockgether T, Feinstein DL.

J Neurosci. 2002 Apr 1;22(7):2434-42.

3.

A comprehensive analysis of the effect of DSP4 on the locus coeruleus noradrenergic system in the rat.

Szot P, Miguelez C, White SS, Franklin A, Sikkema C, Wilkinson CW, Ugedo L, Raskind MA.

Neuroscience. 2010 Mar 10;166(1):279-91. doi: 10.1016/j.neuroscience.2009.12.027. Epub 2010 Jan 4.

4.

Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease.

Kalinin S, Gavrilyuk V, Polak PE, Vasser R, Zhao J, Heneka MT, Feinstein DL.

Neurobiol Aging. 2007 Aug;28(8):1206-14. Epub 2006 Jul 11.

PMID:
16837104
5.

Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.

Pugh PL, Vidgeon-Hart MP, Ashmeade T, Culbert AA, Seymour Z, Perren MJ, Joyce F, Bate ST, Babin A, Virley DJ, Richardson JC, Upton N, Sunter D.

J Neuroinflammation. 2007 Feb 26;4:8.

7.

DSP4, a selective neurotoxin for the locus coeruleus noradrenergic system. A review of its mode of action.

Ross SB, Stenfors C.

Neurotox Res. 2015 Jan;27(1):15-30. doi: 10.1007/s12640-014-9482-z. Epub 2014 Jun 26. Review.

PMID:
24964753
8.

A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats.

Bharani KL, Derex R, Granholm AC, Ledreux A.

PLoS One. 2017 Dec 19;12(12):e0189821. doi: 10.1371/journal.pone.0189821. eCollection 2017.

9.

Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice.

Jardanhazi-Kurutz D, Kummer MP, Terwel D, Vogel K, Thiele A, Heneka MT.

Neuroscience. 2011 Mar 10;176:396-407. doi: 10.1016/j.neuroscience.2010.11.052. Epub 2010 Dec 1.

PMID:
21129451
10.

Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits.

Jardanhazi-Kurutz D, Kummer MP, Terwel D, Vogel K, Dyrks T, Thiele A, Heneka MT.

Neurochem Int. 2010 Nov;57(4):375-82. doi: 10.1016/j.neuint.2010.02.001. Epub 2010 Feb 6.

PMID:
20144675
11.

Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice.

Chalermpalanupap T, Schroeder JP, Rorabaugh JM, Liles LC, Lah JJ, Levey AI, Weinshenker D.

J Neurosci. 2018 Jan 3;38(1):74-92. doi: 10.1523/JNEUROSCI.1483-17.2017. Epub 2017 Nov 13.

13.

Effect of DSP4 and desipramine in the sensorial and affective component of neuropathic pain in rats.

Bravo L, Mico JA, Rey-Brea R, Camarena-Delgado C, Berrocoso E.

Prog Neuropsychopharmacol Biol Psychiatry. 2016 Oct 3;70:57-67. doi: 10.1016/j.pnpbp.2016.05.002. Epub 2016 May 12.

PMID:
27181607
14.

Recovery of central noradrenergic neurons one year after the administration of the neurotoxin DSP4.

Wolfman C, Abó V, Calvo D, Medina J, Dajas F, Silveira R.

Neurochem Int. 1994 Oct;25(4):395-400.

PMID:
7820072
15.

Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice.

Heneka MT, Ramanathan M, Jacobs AH, Dumitrescu-Ozimek L, Bilkei-Gorzo A, Debeir T, Sastre M, Galldiks N, Zimmer A, Hoehn M, Heiss WD, Klockgether T, Staufenbiel M.

J Neurosci. 2006 Feb 1;26(5):1343-54.

16.

Role of norepinephrine in forebrain and brainstem seizures: chemical lesioning of locus ceruleus with DSP4.

Mishra PK, Burger RL, Bettendorf AF, Browning RA, Jobe PC.

Exp Neurol. 1994 Jan;125(1):58-64.

PMID:
8307124
17.

DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine)--a useful denervation tool for central and peripheral noradrenaline neurons.

Jonsson G, Hallman H, Ponzio F, Ross S.

Eur J Pharmacol. 1981 Jun 19;72(2-3):173-88.

PMID:
6265244
18.
19.

Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer's disease.

Ádori C, Glück L, Barde S, Yoshitake T, Kovacs GG, Mulder J, Maglóczky Z, Havas L, Bölcskei K, Mitsios N, Uhlén M, Szolcsányi J, Kehr J, Rönnbäck A, Schwartz T, Rehfeld JF, Harkany T, Palkovits M, Schulz S, Hökfelt T.

Acta Neuropathol. 2015 Apr;129(4):541-63. doi: 10.1007/s00401-015-1394-3. Epub 2015 Feb 13.

PMID:
25676386

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