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Manipulation of the Alternative NF-κB Pathway in Mice Has Sexually Dimorphic Effects on Bone.

Zarei A, Yang C, Gibbs J, Davis JL, Ballard A, Zeng R, Cox L, Veis DJ.

JBMR Plus. 2018 Aug 23;3(1):14-22. doi: 10.1002/jbm4.10066. eCollection 2019 Jan.


The pivotal role of the alternative NF-kappaB pathway in maintenance of basal bone homeostasis and osteoclastogenesis.

Soysa NS, Alles N, Weih D, Lovas A, Mian AH, Shimokawa H, Yasuda H, Weih F, Jimi E, Ohya K, Aoki K.

J Bone Miner Res. 2010 Apr;25(4):809-18. doi: 10.1359/jbmr.091030.


RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation.

Vaira S, Johnson T, Hirbe AC, Alhawagri M, Anwisye I, Sammut B, O'Neal J, Zou W, Weilbaecher KN, Faccio R, Novack DV.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3897-902. doi: 10.1073/pnas.0708576105. Epub 2008 Mar 5.


Alternative NF-κB Regulates RANKL-Induced Osteoclast Differentiation and Mitochondrial Biogenesis via Independent Mechanisms.

Zeng R, Faccio R, Novack DV.

J Bone Miner Res. 2015 Dec;30(12):2287-99. doi: 10.1002/jbmr.2584. Epub 2015 Aug 6.


Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells.

Tchoghandjian A, Jennewein C, Eckhardt I, Rajalingam K, Fulda S.

Cell Death Dis. 2013 Mar 28;4:e564. doi: 10.1038/cddis.2013.70.


RelB-induced expression of Cot, an MAP3K family member, rescues RANKL-induced osteoclastogenesis in alymphoplasia mice by promoting NF-κB2 processing by IKKα.

Taniguchi R, Fukushima H, Osawa K, Maruyama T, Yasuda H, Weih F, Doi T, Maki K, Jimi E.

J Biol Chem. 2014 Mar 14;289(11):7349-61. doi: 10.1074/jbc.M113.538314. Epub 2014 Jan 31.


NLRP12 provides a critical checkpoint for osteoclast differentiation.

Krauss JL, Zeng R, Hickman-Brecks CL, Wilson JE, Ting JP, Novack DV.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10455-60. doi: 10.1073/pnas.1500196112. Epub 2015 Aug 3.


Smac mimetic promotes glioblastoma cancer stem-like cell differentiation by activating NF-κB.

Tchoghandjian A, Jennewein C, Eckhardt I, Momma S, Figarella-Branger D, Fulda S.

Cell Death Differ. 2014 May;21(5):735-47. doi: 10.1038/cdd.2013.200. Epub 2014 Jan 31.


Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation.

Yang C, Davis JL, Zeng R, Vora P, Su X, Collins LI, Vangveravong S, Mach RH, Piwnica-Worms D, Weilbaecher KN, Faccio R, Novack DV.

Cancer Discov. 2013 Feb;3(2):212-23. doi: 10.1158/2159-8290.CD-12-0271. Epub 2012 Dec 26.


Defective nuclear factor-κB-inducing kinase in aly/aly mice prevents bone resorption induced by local injection of lipopolysaccharide.

Soysa NS, Alles N, Takahashi M, Aoki K, Ohya K.

J Periodontal Res. 2011 Apr;46(2):280-4. doi: 10.1111/j.1600-0765.2010.01333.x. Epub 2010 Dec 29.


Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner.

Wagner L, Marschall V, Karl S, Cristofanon S, Zobel K, Deshayes K, Vucic D, Debatin KM, Fulda S.

Oncogene. 2013 Feb 21;32(8):988-97. doi: 10.1038/onc.2012.108. Epub 2012 Apr 2.


NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis.

Yang C, McCoy K, Davis JL, Schmidt-Supprian M, Sasaki Y, Faccio R, Novack DV.

PLoS One. 2010 Nov 8;5(11):e15383. doi: 10.1371/journal.pone.0015383.


The RelB alternative NF-kappaB subunit promotes autophagy in 22Rv1 prostate cancer cells in vitro and affects mouse xenograft tumor growth in vivo.

Labouba I, Poisson A, Lafontaine J, Delvoye N, Gannon PO, Le Page C, Saad F, Mes-Masson AM.

Cancer Cell Int. 2014 Jul 28;14:67. doi: 10.1186/1475-2867-14-67. eCollection 2014.


Lipopolysaccharide-induced activation of NF-κB non-canonical pathway requires BCL10 serine 138 and NIK phosphorylations.

Bhattacharyya S, Borthakur A, Dudeja PK, Tobacman JK.

Exp Cell Res. 2010 Nov 15;316(19):3317-27. doi: 10.1016/j.yexcr.2010.05.004. Epub 2010 May 11.


Constitutively active canonical NF-κB pathway induces severe bone loss in mice.

Otero JE, Chen T, Zhang K, Abu-Amer Y.

PLoS One. 2012;7(6):e38694. doi: 10.1371/journal.pone.0038694. Epub 2012 Jun 7.


TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway.

Al-Sadi R, Guo S, Ye D, Rawat M, Ma TY.

Am J Pathol. 2016 May;186(5):1151-65. doi: 10.1016/j.ajpath.2015.12.016. Epub 2016 Mar 4.


The NF-κB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100.

Fusco AJ, Mazumder A, Wang VY, Tao Z, Ware C, Ghosh G.

Sci Signal. 2016 Sep 27;9(447):ra96. doi: 10.1126/scisignal.aad9413.


Suppression of NF-kappaB increases bone formation and ameliorates osteopenia in ovariectomized mice.

Alles N, Soysa NS, Hayashi J, Khan M, Shimoda A, Shimokawa H, Ritzeler O, Akiyoshi K, Aoki K, Ohya K.

Endocrinology. 2010 Oct;151(10):4626-34. doi: 10.1210/en.2010-0399. Epub 2010 Sep 1.


Glucocorticoid receptor signaling contributes to constitutive activation of the noncanonical NF-κB pathway in term human placenta.

Wang B, Palomares K, Parobchak N, Cece J, Rosen M, Nguyen A, Rosen T.

Mol Endocrinol. 2013 Feb;27(2):203-11. doi: 10.1210/me.2012-1309. Epub 2012 Dec 13.

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