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Items: 1 to 20 of 100

1.

Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery.

Yan H, Duan X, Pan H, Akk A, Sandell LJ, Wickline SA, Rai MF, Pham CTN.

Sci Rep. 2019 Jan 24;9(1):442. doi: 10.1038/s41598-018-37018-3.

2.

Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury.

Yan H, Duan X, Pan H, Holguin N, Rai MF, Akk A, Springer LE, Wickline SA, Sandell LJ, Pham CT.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6199-E6208. Epub 2016 Sep 28. Erratum in: Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3871.

3.

Intra-articular delivery of anti-Hif-2α siRNA by chondrocyte-homing nanoparticles to prevent cartilage degeneration in arthritic mice.

Pi Y, Zhang X, Shao Z, Zhao F, Hu X, Ao Y.

Gene Ther. 2015 Jun;22(6):439-48. doi: 10.1038/gt.2015.16. Epub 2015 Apr 16.

PMID:
25876463
4.

Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL-1β/NF-κB pathway.

Wang Z, Huang J, Zhou S, Luo F, Xu W, Wang Q, Tan Q, Chen L, Wang J, Chen H, Chen L, Xie Y, Du X.

J Cell Mol Med. 2017 Dec;21(12):3231-3243. doi: 10.1111/jcmm.13227. Epub 2017 Jun 23.

5.

IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway.

Montaseri A, Busch F, Mobasheri A, Buhrmann C, Aldinger C, Rad JS, Shakibaei M.

PLoS One. 2011;6(12):e28663. doi: 10.1371/journal.pone.0028663. Epub 2011 Dec 14.

6.

Lithium protects against cartilage degradation in osteoarthritis.

Minashima T, Zhang Y, Lee Y, Kirsch T.

Arthritis Rheumatol. 2014 May;66(5):1228-36. doi: 10.1002/art.38373.

7.

Sam68 Promotes NF-κB Activation and Apoptosis Signaling in Articular Chondrocytes during Osteoarthritis.

Xu L, Sun C, Zhang S, Xu X, Zhai L, Wang Y, Wang S, Liu Z, Cheng H, Xiao M, Tao R, Zhang D.

Inflamm Res. 2015 Nov;64(11):895-902. doi: 10.1007/s00011-015-0872-3. Epub 2015 Sep 9.

PMID:
26350037
8.

PEP-1-GRX-1 Modulates Matrix Metalloproteinase-13 and Nitric Oxide Expression of Human Articular Chondrocytes.

Hwang HS, Park IY, Kim HA, Choi SY.

Cell Physiol Biochem. 2017;41(1):252-264. doi: 10.1159/000456090. Epub 2016 Jan 23.

9.

Annexin A6 interacts with p65 and stimulates NF-κB activity and catabolic events in articular chondrocytes.

Campbell KA, Minashima T, Zhang Y, Hadley S, Lee YJ, Giovinazzo J, Quirno M, Kirsch T.

Arthritis Rheum. 2013 Dec;65(12):3120-9. doi: 10.1002/art.38182.

10.

Acetazolamide protects rat articular chondrocytes from IL-1β-induced apoptosis by inhibiting the activation of NF-κB signal pathway.

Cai L, Chen WN, Li R, Liu MM, Lei C, Li CM, Qiu YY.

Can J Physiol Pharmacol. 2018 Nov;96(11):1104-1111. doi: 10.1139/cjpp-2018-0334. Epub 2018 Aug 1.

PMID:
30067070
11.

Mori folium inhibits interleukin-1β-induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF-κB and p38 MAPK in SW1353 human chondrocytes.

Jeong JW, Lee HH, Lee KW, Kim KY, Kim SG, Hong SH, Kim GY, Park C, Kim HK, Choi YW, Choi YH.

Int J Mol Med. 2016 Feb;37(2):452-60. doi: 10.3892/ijmm.2015.2443. Epub 2015 Dec 23.

PMID:
26707272
12.
13.

Alpha-Mangostin protects rat articular chondrocytes against IL-1β-induced inflammation and slows the progression of osteoarthritis in a rat model.

Pan T, Wu D, Cai N, Chen R, Shi X, Li B, Pan J.

Int Immunopharmacol. 2017 Nov;52:34-43. doi: 10.1016/j.intimp.2017.08.010. Epub 2017 Aug 31.

PMID:
28858724
14.

Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis.

Shakibaei M, Csaki C, Nebrich S, Mobasheri A.

Biochem Pharmacol. 2008 Dec 1;76(11):1426-39. doi: 10.1016/j.bcp.2008.05.029. Epub 2008 Jun 3.

PMID:
18606398
15.

Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β.

Thompson CL, Patel R, Kelly TA, Wann AK, Hung CT, Chapple JP, Knight MM.

Arthritis Res Ther. 2015 Dec 24;17:373. doi: 10.1186/s13075-015-0891-z.

16.
17.

Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes.

Khan NM, Haseeb A, Ansari MY, Devarapalli P, Haynie S, Haqqi TM.

Free Radic Biol Med. 2017 May;106:288-301. doi: 10.1016/j.freeradbiomed.2017.02.041. Epub 2017 Feb 22.

18.

Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis.

Zhou HF, Yan H, Pan H, Hou KK, Akk A, Springer LE, Hu Y, Allen JS, Wickline SA, Pham CT.

J Clin Invest. 2014 Oct;124(10):4363-74. doi: 10.1172/JCI75673. Epub 2014 Aug 26.

19.

Cyclin-dependent kinase 9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines.

Yik JH, Hu Z, Kumari R, Christiansen BA, Haudenschild DR.

Arthritis Rheumatol. 2014 Jun;66(6):1537-46. doi: 10.1002/art.38378.

20.

Isoliquiritigenin Inhibits IL-1β-Induced Production of Matrix Metalloproteinase in Articular Chondrocytes.

Zhang L, Ma S, Su H, Cheng J.

Mol Ther Methods Clin Dev. 2018 Feb 15;9:153-159. doi: 10.1016/j.omtm.2018.02.006. eCollection 2018 Jun 15.

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