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Items: 1 to 20 of 103

1.

Small-molecule targeting of brachyury transcription factor addiction in chordoma.

Sharifnia T, Wawer MJ, Chen T, Huang QY, Weir BA, Sizemore A, Lawlor MA, Goodale A, Cowley GS, Vazquez F, Ott CJ, Francis JM, Sassi S, Cogswell P, Sheppard HE, Zhang T, Gray NS, Clarke PA, Blagg J, Workman P, Sommer J, Hornicek F, Root DE, Hahn WC, Bradner JE, Wong KK, Clemons PA, Lin CY, Kotz JD, Schreiber SL.

Nat Med. 2019 Feb;25(2):292-300. doi: 10.1038/s41591-018-0312-3. Epub 2019 Jan 21.

PMID:
30664779
2.

The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival.

Hu Y, Mintz A, Shah SR, Quinones-Hinojosa A, Hsu W.

Carcinogenesis. 2014 Jul;35(7):1491-9. doi: 10.1093/carcin/bgu014. Epub 2014 Jan 20.

3.

Afatinib Is a New Therapeutic Approach in Chordoma with a Unique Ability to Target EGFR and Brachyury.

Magnaghi P, Salom B, Cozzi L, Amboldi N, Ballinari D, Tamborini E, Gasparri F, Montagnoli A, Raddrizzani L, Somaschini A, Bosotti R, Orrenius C, Bozzi F, Pilotti S, Galvani A, Sommer J, Stacchiotti S, Isacchi A.

Mol Cancer Ther. 2018 Mar;17(3):603-613. doi: 10.1158/1535-7163.MCT-17-0324. Epub 2017 Dec 13.

4.

Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target.

Hsu W, Mohyeldin A, Shah SR, ap Rhys CM, Johnson LF, Sedora-Roman NI, Kosztowski TA, Awad OA, McCarthy EF, Loeb DM, Wolinsky JP, Gokaslan ZL, Quiñones-Hinojosa A.

J Neurosurg. 2011 Oct;115(4):760-9. doi: 10.3171/2011.5.JNS11185. Epub 2011 Jun 24.

5.

Notochordal Tumors: An Update on Molecular Pathology with Therapeutic Implications.

Yamaguchi T, Imada H, Iida S, Szuhai K.

Surg Pathol Clin. 2017 Sep;10(3):637-656. doi: 10.1016/j.path.2017.04.008. Epub 2017 Jun 29. Review.

PMID:
28797506
6.

Liposome-Protamine-DNA Nanoparticle-Mediated Delivery of Short Hairpin RNA Targeting Brachyury Inhibits Chordoma Cell Growth.

Hu Y, Singh R, Deng Z, Mintz A, Hsu W.

J Biomed Nanotechnol. 2016 Oct;12(10):1952-61.

PMID:
29360338
7.

From notochord formation to hereditary chordoma: the many roles of Brachyury.

Nibu Y, José-Edwards DS, Di Gregorio A.

Biomed Res Int. 2013;2013:826435. doi: 10.1155/2013/826435. Epub 2013 Mar 31. Review.

8.

Specificity of brachyury in the distinction of chordoma from clear cell renal cell carcinoma and germ cell tumors: a study of 305 cases.

Sangoi AR, Karamchandani J, Lane B, Higgins JP, Rouse RV, Brooks JD, McKenney JK.

Mod Pathol. 2011 Mar;24(3):425-9. doi: 10.1038/modpathol.2010.196. Epub 2010 Nov 19.

9.

An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.

Nelson AC, Pillay N, Henderson S, Presneau N, Tirabosco R, Halai D, Berisha F, Flicek P, Stemple DL, Stern CD, Wardle FC, Flanagan AM.

J Pathol. 2012 Nov;228(3):274-85. doi: 10.1002/path.4082. Epub 2012 Sep 26.

10.

Classic chordoma coexisting with benign notochordal cell rest demonstrating different immunohistological expression patterns of brachyury and galectin-3.

Shen J, Li CD, Yang HL, Lu J, Zou TM, Wang DL, Deng M.

J Clin Neurosci. 2011 Jan;18(1):96-9. doi: 10.1016/j.jocn.2010.03.066. Epub 2010 Sep 19.

PMID:
20855213
11.

Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines.

Karikari IO, Gilchrist CL, Jing L, Alcorta DA, Chen J, Richardson WJ, Gabr MA, Bell RD, Kelley MJ, Bagley CA, Setton LA.

J Neurosurg Spine. 2014 Sep;21(3):386-93. doi: 10.3171/2014.4.SPINE13262. Epub 2014 Jun 6.

12.

Anaplastic chordoma with loss of INI1 and brachyury expression in a 2-year-old girl.

Chavez JA, Nasir Ud Din, Memon A, Perry A.

Clin Neuropathol. 2014 Nov-Dec;33(6):418-20. doi: 10.5414/NP300724. No abstract available.

PMID:
25074874
13.

Analysis of the fibroblastic growth factor receptor-RAS/RAF/MEK/ERK-ETS2/brachyury signalling pathway in chordomas.

Shalaby AA, Presneau N, Idowu BD, Thompson L, Briggs TR, Tirabosco R, Diss TC, Flanagan AM.

Mod Pathol. 2009 Aug;22(8):996-1005. doi: 10.1038/modpathol.2009.63. Epub 2009 May 1.

14.

Brachyury: a diagnostic marker for the differential diagnosis of chordoma and hemangioblastoma versus neoplastic histological mimickers.

Barresi V, Ieni A, Branca G, Tuccari G.

Dis Markers. 2014;2014:514753. doi: 10.1155/2014/514753. Epub 2014 Jan 21. Review.

15.

Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.

Presneau N, Shalaby A, Ye H, Pillay N, Halai D, Idowu B, Tirabosco R, Whitwell D, Jacques TS, Kindblom LG, Brüderlein S, Möller P, Leithner A, Liegl B, Amary FM, Athanasou NN, Hogendoorn PC, Mertens F, Szuhai K, Flanagan AM.

J Pathol. 2011 Feb;223(3):327-35. doi: 10.1002/path.2816. Epub 2010 Nov 24.

PMID:
21171078
16.

Tissue microarray immunohistochemical detection of brachyury is not a prognostic indicator in chordoma.

Zhang L, Guo S, Schwab JH, Nielsen GP, Choy E, Ye S, Zhang Z, Mankin H, Hornicek FJ, Duan Z.

PLoS One. 2013 Sep 23;8(9):e75851. doi: 10.1371/journal.pone.0075851. eCollection 2013.

17.

Revisiting chordoma with brachyury, a "new age" marker: analysis of a validation study on 51 cases.

Jambhekar NA, Rekhi B, Thorat K, Dikshit R, Agrawal M, Puri A.

Arch Pathol Lab Med. 2010 Aug;134(8):1181-7. doi: 10.1043/2009-0476-OA.1.

PMID:
20670140
18.

Diagnosing an extra-axial chordoma of the proximal tibia with the help of brachyury, a molecule required for notochordal differentiation.

O'donnell P, Tirabosco R, Vujovic S, Bartlett W, Briggs TW, Henderson S, Boshoff C, Flanagan AM.

Skeletal Radiol. 2007 Jan;36(1):59-65. Epub 2006 Jun 30.

PMID:
16810540
19.

The driver landscape of sporadic chordoma.

Tarpey PS, Behjati S, Young MD, Martincorena I, Alexandrov LB, Farndon SJ, Guzzo C, Hardy C, Latimer C, Butler AP, Teague JW, Shlien A, Futreal PA, Shah S, Bashashati A, Jamshidi F, Nielsen TO, Huntsman D, Baumhoer D, Brandner S, Wunder J, Dickson B, Cogswell P, Sommer J, Phillips JJ, Amary MF, Tirabosco R, Pillay N, Yip S, Stratton MR, Flanagan AM, Campbell PJ.

Nat Commun. 2017 Oct 12;8(1):890. doi: 10.1038/s41467-017-01026-0.

20.

Nuclear Brachyury Expression Is Consistent in Chordoma, Common in Germ Cell Tumors and Small Cell Carcinomas, and Rare in Other Carcinomas and Sarcomas: An Immunohistochemical Study of 5229 Cases.

Miettinen M, Wang Z, Lasota J, Heery C, Schlom J, Palena C.

Am J Surg Pathol. 2015 Oct;39(10):1305-12. doi: 10.1097/PAS.0000000000000462.

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