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Items: 1 to 20 of 95

1.

Drug-free macromolecular therapeutics induce apoptosis in cells isolated from patients with B cell malignancies with enhanced apoptosis induction by pretreatment with gemcitabine.

Wang J, Li L, Yang J, Clair PM, Glenn MJ, Stephens DM, Radford DC, Kosak KM, Deininger MW, Shami PJ, Kopeček J.

Nanomedicine. 2019 Feb;16:217-225. doi: 10.1016/j.nano.2018.12.011. Epub 2019 Jan 9.

PMID:
30639670
2.

Drug-free macromolecular therapeutics: Impact of structure on induction of apoptosis in Raji B cells.

Zhang L, Fang Y, Yang J, Kopeček J.

J Control Release. 2017 Oct 10;263:139-150. doi: 10.1016/j.jconrel.2016.12.025. Epub 2016 Dec 24.

3.

Amplification of CD20 Cross-Linking in Rituximab-Resistant B-Lymphoma Cells Enhances Apoptosis Induction by Drug-Free Macromolecular Therapeutics.

Li L, Yang J, Wang J, Kopeček J.

ACS Nano. 2018 Apr 24;12(4):3658-3670. doi: 10.1021/acsnano.8b00797. Epub 2018 Apr 2.

4.

Human Serum Albumin-Based Drug-Free Macromolecular Therapeutics: Apoptosis Induction by Coiled-Coil-Mediated Cross-Linking of CD20 Antigens on Lymphoma B Cell Surface.

Zhang L, Fang Y, Li L, Yang J, Radford DC, Kopeček J.

Macromol Biosci. 2018 Nov;18(11):e1800224. doi: 10.1002/mabi.201800224. Epub 2018 Sep 27.

PMID:
30259654
5.

Biorecognition: A key to drug-free macromolecular therapeutics.

Yang J, Li L, Kopeček J.

Biomaterials. 2019 Jan;190-191:11-23. doi: 10.1016/j.biomaterials.2018.10.007. Epub 2018 Oct 12. Review.

PMID:
30391799
6.

Drug-free macromolecular therapeutics exhibit amplified apoptosis in G2/M phase arrested cells.

Li L, Yang J, Wang J, Kopeček J.

J Drug Target. 2019 Jun - Jul;27(5-6):566-572. doi: 10.1080/1061186X.2018.1521414. Epub 2018 Dec 10.

PMID:
30198798
7.

Cell surface self-assembly of hybrid nanoconjugates via oligonucleotide hybridization induces apoptosis.

Chu TW, Yang J, Zhang R, Sima M, Kopeček J.

ACS Nano. 2014 Jan 28;8(1):719-30. doi: 10.1021/nn4053827. Epub 2013 Dec 10.

8.

Drug-free macromolecular therapeutics induce apoptosis of patient chronic lymphocytic leukemia cells.

Chu TW, Kosak KM, Shami PJ, Kopeček J.

Drug Deliv Transl Res. 2014 Dec;4(5-6):389-94. doi: 10.1007/s13346-014-0209-8.

9.

A Two-Step Pretargeted Nanotherapy for CD20 Crosslinking May Achieve Superior Anti-Lymphoma Efficacy to Rituximab.

Chu TW, Zhang R, Yang J, Chao MP, Shami PJ, Kopeček J.

Theranostics. 2015 Apr 26;5(8):834-46. doi: 10.7150/thno.12040. eCollection 2015.

10.

Multimodality imaging of coiled-coil mediated self-assembly in a "drug-free" therapeutic system.

Zhang R, Yang J, Chu TW, Hartley JM, Kopeček J.

Adv Healthc Mater. 2015 May;4(7):1054-65. doi: 10.1002/adhm.201400679. Epub 2015 Jan 21.

11.

Design of smart HPMA copolymer-based nanomedicines.

Yang J, Kopeček J.

J Control Release. 2016 Oct 28;240:9-23. doi: 10.1016/j.jconrel.2015.10.003. Epub 2015 Oct 3. Review.

12.

Drug-Free Macromolecular Therapeutics Induce Apoptosis via Calcium Influx and Mitochondrial Signaling Pathway.

Li L, Yang J, Wang J, Kopeček J.

Macromol Biosci. 2018 Jan;18(1). doi: 10.1002/mabi.201700196. Epub 2017 Aug 14.

13.

Anti-CD20 multivalent HPMA copolymer-Fab' conjugates for the direct induction of apoptosis.

Chu TW, Yang J, Kopeček J.

Biomaterials. 2012 Oct;33(29):7174-81. doi: 10.1016/j.biomaterials.2012.06.024. Epub 2012 Jul 12.

14.

Immunogenicity of coiled-coil based drug-free macromolecular therapeutics.

Kverka M, Hartley JM, Chu TW, Yang J, Heidchen R, Kopeček J.

Biomaterials. 2014 Jul;35(22):5886-96. doi: 10.1016/j.biomaterials.2014.03.063. Epub 2014 Apr 22.

15.

Biological activity of anti-CD20 multivalent HPMA copolymer-Fab' conjugates.

Johnson RN, Kopečková P, Kopeček J.

Biomacromolecules. 2012 Mar 12;13(3):727-35. doi: 10.1021/bm201656k. Epub 2012 Feb 21.

16.

Coiled-coil based drug-free macromolecular therapeutics: in vivo efficacy.

Wu K, Yang J, Liu J, Kopeček J.

J Control Release. 2012 Jan 10;157(1):126-31. doi: 10.1016/j.jconrel.2011.08.002. Epub 2011 Aug 6.

17.

Gemcitabine enhances rituximab-mediated complement-dependent cytotoxicity to B cell lymphoma by CD20 upregulation.

Hayashi K, Nagasaki E, Kan S, Ito M, Kamata Y, Homma S, Aiba K.

Cancer Sci. 2016 May;107(5):682-9. doi: 10.1111/cas.12918. Epub 2016 Apr 7.

18.

Drug-Free Macromolecular Therapeutics--A New Paradigm in Polymeric Nanomedicines.

Chu TW, Kopeček J.

Biomater Sci. 2015 Jul;3(7):908-22. doi: 10.1039/C4BM00442F.

19.

Binding to CD20 by anti-B1 antibody or F(ab')(2) is sufficient for induction of apoptosis in B-cell lines.

Cardarelli PM, Quinn M, Buckman D, Fang Y, Colcher D, King DJ, Bebbington C, Yarranton G.

Cancer Immunol Immunother. 2002 Mar;51(1):15-24. Epub 2001 Dec 18.

PMID:
11845256
20.

Backbone Degradable N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates with Gemcitabine and Paclitaxel: Impact of Molecular Weight on Activity toward Human Ovarian Carcinoma Xenografts.

Yang J, Zhang R, Pan H, Li Y, Fang Y, Zhang L, Kopeček J.

Mol Pharm. 2017 May 1;14(5):1384-1394. doi: 10.1021/acs.molpharmaceut.6b01005. Epub 2017 Feb 3.

PMID:
28094954

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