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Items: 1 to 20 of 85

1.

Correction to Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.

Cinelli MA, Li H, Chreifi G, Poulos TL, Silverman RB.

J Med Chem. 2019 Jan 24;62(2):1075. doi: 10.1021/acs.jmedchem.8b02033. Epub 2019 Jan 11. No abstract available.

PMID:
30633512
2.

Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.

Cinelli MA, Li H, Chreifi G, Poulos TL, Silverman RB.

J Med Chem. 2017 May 11;60(9):3958-3978. doi: 10.1021/acs.jmedchem.7b00259. Epub 2017 Apr 19. Erratum in: J Med Chem. 2019 Jan 24;62(2):1075.

3.

Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition.

Cinelli MA, Li H, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB.

J Med Chem. 2014 Feb 27;57(4):1513-30. doi: 10.1021/jm401838x. Epub 2014 Feb 10.

4.

Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.

Cinelli MA, Li H, Pensa AV, Kang S, Roman LJ, Martásek P, Poulos TL, Silverman RB.

J Med Chem. 2015 Nov 12;58(21):8694-712. doi: 10.1021/acs.jmedchem.5b01330. Epub 2015 Oct 27. Erratum in: J Med Chem. 2016 Feb 11;59(3):1246.

5.

Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.

Xue F, Li H, Fang J, Roman LJ, Martásek P, Poulos TL, Silverman RB.

Bioorg Med Chem Lett. 2010 Nov 1;20(21):6258-61. doi: 10.1016/j.bmcl.2010.08.096. Epub 2010 Aug 26.

6.

Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.

Pensa AV, Cinelli MA, Li H, Chreifi G, Mukherjee P, Roman LJ, Martásek P, Poulos TL, Silverman RB.

J Med Chem. 2017 Aug 24;60(16):7146-7165. doi: 10.1021/acs.jmedchem.7b00835. Epub 2017 Aug 4.

7.

Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.

Hah JM, Martásek P, Roman LJ, Silverman RB.

J Med Chem. 2003 Apr 24;46(9):1661-9.

PMID:
12699384
8.

Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors.

Ji H, Gómez-Vidal JA, Martasek P, Roman LJ, Silverman RB.

J Med Chem. 2006 Oct 19;49(21):6254-63.

9.

Novel potent and selective inhibitors of inducible nitric oxide synthase.

Nakane M, Klinghofer V, Kuk JE, Donnelly JL, Budzik GP, Pollock JS, Basha F, Carter GW.

Mol Pharmacol. 1995 Apr;47(4):831-4.

PMID:
7536889
10.

Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.

Ji H, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB.

J Med Chem. 2009 Feb 12;52(3):779-97. doi: 10.1021/jm801220a.

11.

In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.

Jing Q, Li H, Fang J, Roman LJ, Martásek P, Poulos TL, Silverman RB.

Bioorg Med Chem. 2013 Sep 1;21(17):5323-31. doi: 10.1016/j.bmc.2013.06.014. Epub 2013 Jun 15.

12.

2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase.

Hagen TJ, Bergmanis AA, Kramer SW, Fok KF, Schmelzer AE, Pitzele BS, Swenton L, Jerome GM, Kornmeier CM, Moore WM, Branson LF, Connor JR, Manning PT, Currie MG, Hallinan EA.

J Med Chem. 1998 Sep 10;41(19):3675-83.

PMID:
9733492
14.

Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors.

Gómez-Vidal JA, Martásek P, Roman LJ, Silverman RB.

J Med Chem. 2004 Jan 29;47(3):703-10.

PMID:
14736250
15.

Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors.

Holden JK, Lewis MC, Cinelli MA, Abdullatif Z, Pensa AV, Silverman RB, Poulos TL.

Biochemistry. 2016 Oct 4;55(39):5587-5594. Epub 2016 Sep 21.

16.

Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis.

Facchinetti F, Sasaki M, Cutting FB, Zhai P, MacDonald JE, Reif D, Beal MF, Huang PL, Dawson TM, Gurney ME, Dawson VL.

Neuroscience. 1999;90(4):1483-92.

PMID:
10338314
17.

Correction to Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.

Cinelli MA, Li H, Pensa AV, Kang S, Roman LJ, Martásek P, Poulos TL, Silverman RB.

J Med Chem. 2016 Feb 11;59(3):1246. doi: 10.1021/acs.jmedchem.6b00036. Epub 2016 Jan 25. No abstract available.

18.

Effects of selective and non-selective inhibitors of nitric oxide synthase on morphine- and endomorphin-1-induced analgesia in acute and neuropathic pain in rats.

Makuch W, Mika J, Rojewska E, Zychowska M, Przewlocka B.

Neuropharmacology. 2013 Dec;75:445-57. doi: 10.1016/j.neuropharm.2013.08.031. Epub 2013 Sep 10.

PMID:
24035921
19.

Inhibition of neuronal nitric oxide synthase reduces the propofol requirements in wild-type and nNOS knockout mice.

Engelhardt T, Lowe PR, Galley HF, Webster NR.

Eur J Anaesthesiol. 2006 Mar;23(3):197-201.

PMID:
16430790
20.

A Comparison of the Effects of Neuronal Nitric Oxide Synthase and Inducible Nitric Oxide Synthase Inhibition on Cartilage Damage.

Gokay NS, Yilmaz I, Komur B, Demiroz AS, Gokce A, Dervisoglu S, Gokay BV.

Biomed Res Int. 2016;2016:7857345. doi: 10.1155/2016/7857345. Epub 2016 Jun 13.

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