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30587243,28985236,28107750,31661956,27518281,28406899,19538992,29498707,24657767,24086136,36250286,35970392,24809504,25996070,31730617,35983937,24069483,26305466,30455056,29782530,30399512,27344453,29155817,18977200,26713732,26937828,32178714,22414701,34793443,27806050,28637488,33044962,25243797,32973031,34392190,31718145,31496251,28506839,24602876,28840376,29806110,28639720,31221193,29617630,30365505,32127065,30689639,27981795,26409899,30610241,28622767,33279862,23876575,25910674,26071648,27128493,17411340,22006193,33925246,20210674,26595183,32663671,27490394,27528511,16427147,34033658,22607147,27836498,30276965,25803425,28259528,31765429,28666754,34731172,29197426,6511145,25941940,22163059,15013742,27761814,32609727,19885392,26644133,27693560,18346457,16246438,25933436,33784302,29331278,30733716,26445012,20605744,25482284,11304533,19094990,17577588,25325257,28686009,19814844,24733477,25663090,26303428,22124550,32737161,34843489,18413789,29240773,31939288,25768432,29746471,31816172,29346437,14668020,34665914,19597541,34536671,33299037,23696913,30669086,11887217,19901992,32374726,24904967,30398059,28114363,26751972,32810153,35865824,24945272,24041901,30126190,21251927,31027918,19364765,35732073,19956564,32531750,10413041,30897528,33657105,17214506,32428996,31640761,9585934,30245402,35056137,33075069,19549517,15735581,23148687,24884876,30166569,17363504,32730343,30597185,26858181,24050069,26230921,24037192,32451999,20488212,31170410,32504755,35812433,32615359,1558275,32424554,29760143,32961206,25569258,32918996,20976050,21348610,34022917,11193693,12204228,19812222,20706580,26238343,6751680,24013345,32904763,24489942,32452008,21247453,20097200,12429021,15796014,6795772,25992548,36587730,32963637,572149,31561039,23061657,31362766,36910171,23199404,21825060,32696211,28874839,9460257,26153121,19463860,20852890,21829186,19198654,31067225,30776695,29477861,31201303,9921354,30664827,12204221,21832058,26303421,33263166,14643295,27812220,7461088,12613763,29364215,34492240,24870249,15552403,34994284,12973350,15121048,33383024,26076109,12049454,18797767,17653213,29649665,30764562,20419145,25011550,31370708,32451995,33577811,29988015,35025955,8992317,32613694,21300841,4011318,35209202,19065135,16272578,31154018,33339816,9330911,12426597,9481774,8444195,32203512,14978105,19828382,22420337,29921756,19355992,23086444,19317450,30378504,19751207,11172676,12742587,4745233,16611031,7208098,27071187,3122152,21504726,4000276,31103556,35660528,5157124,3117875,18235848,31622335,22553141,32822677,33360801,27253773,5103321,418783,17308764,31083889,5420317,3056735,3338547,33116178,24921927,27734345,33975779,23426263,24945827,6877869,16112986,32260125,20060828,19765348,2382765,25007099,34985259,20161728,21408085,2638727,32451998,7145475,30664899,11166392,29300993,37047792,9198585,35887216,33920436,1343928,32510834,12377210,12878186,29355617,32719718,19095013,24271000,21541360,5690046,35610661,30763656,8359991,35623387,33549669,29669386,31454168,7082074,26904403,8939048,18775750,34358112,12464421,29677188,21548963,26658895,33713647,30297303,10220402,21964251,33771520,31809524,6755246,24674948,33434015,23166854,11071287,10198441,24367716,34547384,5025615,36578572,20532163,24024211,15250464,29459722,31730614,24244773,593727,21670884,23936567,22377319,27187180,20668553,34310727,34150924,30797776,31368626,30870428,32451992,15032657,30665742,17996068,9921358,31958469,35041939,28704396,3614273,34253841,19349466,4795964,4336210,10377119,36794836,11742750,28542189,23908765,31580252,29018227,22363825,24768753,29636801,32846996,31126821,12973528,32973030,22387759,21533168,13092374,5104500,19428677,34539616,32441549,22084571,1582487,24069470,20680343,1374160,7200108,6129940,32452002,18622098,22389736,30581875,30150002,11170365,29355955,23696708,7088034,4823795,32371995,9921351,28326191,33175511,9921353,36475351,33409508,6513987,31952231,31354641,30283426,31681440,29309602,27053189,7063249,19415326,26443722,1639166,7146818,23785292,36154583,6739132,33600427,12170338,27677173,4818667,838033,36385939,22124560,22860151,11512276,22414492,7295894,453899,34056159,6546409,33135408,34680865,31527034,17109780,27547205,604820,1944422,36652479,36892013,25309576,3400801,36331139,34910770,31083316,4927740,36098656,35055970,34859292,36477146,26740209,4797734,35378863,21776387,25473514,17904531,10340491,7669109,11139814,13460239,29977614,19707280,17962074,27066323,35215232,14911219,31788346,33001015,25222834,12079776,31703729,4191307,34959707,6859703,32184954,4995890,24959172,5259279,32985247,30090264,29699152,36465675,19577949,32028743,22027590,15463424,34300316,35620338,35884187,27917100,32970301,27895916,22358537,34358178,5362600,35186154,24305902,36097183,33738059,5960333,24335889,12913489,31043388,15463396,33438796,24305893[uid]

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538 results

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Page 1

Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production.

Guidi A, Saccoccia F, Gennari N, Gimmelli R, Nizi E, Lalli C, Paonessa G, Papoff G, Bresciani A, Ruberti G. Guidi A, et al. Parasit Vectors. 2018 Dec 27;11(1):668. doi: 10.1186/s13071-018-3268-8. Parasit Vectors. 2018. PMID: 30587243 Free PMC article.

Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production.

Guidi A, Lalli C, Gimmelli R, Nizi E, Andreini M, Gennari N, Saccoccia F, Harper S, Bresciani A, Ruberti G. Guidi A, et al. PLoS Negl Trop Dis. 2017 Oct 6;11(10):e0005994. doi: 10.1371/journal.pntd.0005994. eCollection 2017 Oct. PLoS Negl Trop Dis. 2017. PMID: 28985236 Free PMC article.

Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth.

Chua MJ, Arnold MS, Xu W, Lancelot J, Lamotte S, Späth GF, Prina E, Pierce RJ, Fairlie DP, Skinner-Adams TS, Andrews KT. Chua MJ, et al. Int J Parasitol Drugs Drug Resist. 2017 Apr;7(1):42-50. doi: 10.1016/j.ijpddr.2016.12.005. Epub 2016 Dec 23. Int J Parasitol Drugs Drug Resist. 2017. PMID: 28107750 Free PMC article.

Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents.

Saccoccia F, Brindisi M, Gimmelli R, Relitti N, Guidi A, Saraswati AP, Cavella C, Brogi S, Chemi G, Butini S, Papoff G, Senger J, Herp D, Jung M, Campiani G, Gemma S, Ruberti G. Saccoccia F, et al. ACS Infect Dis. 2020 Jan 10;6(1):100-113. doi: 10.1021/acsinfecdis.9b00224. Epub 2019 Nov 12. ACS Infect Dis. 2020. PMID: 31661956

Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems.

Guidi A, Lalli C, Perlas E, Bolasco G, Nibbio M, Monteagudo E, Bresciani A, Ruberti G. Guidi A, et al. PLoS Negl Trop Dis. 2016 Aug 12;10(8):e0004928. doi: 10.1371/journal.pntd.0004928. eCollection 2016 Aug. PLoS Negl Trop Dis. 2016. PMID: 27518281 Free PMC article.

Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni.

Anderson L, Gomes MR, daSilva LF, Pereira ADSA, Mourão MM, Romier C, Pierce R, Verjovski-Almeida S. Anderson L, et al. PLoS Negl Trop Dis. 2017 Apr 13;11(4):e0005539. doi: 10.1371/journal.pntd.0005539. eCollection 2017 Apr. PLoS Negl Trop Dis. 2017. PMID: 28406899 Free PMC article.

Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni.

Dubois F, Caby S, Oger F, Cosseau C, Capron M, Grunau C, Dissous C, Pierce RJ. Dubois F, et al. Mol Biochem Parasitol. 2009 Nov;168(1):7-15. doi: 10.1016/j.molbiopara.2009.06.001. Epub 2009 Jun 16. Mol Biochem Parasitol. 2009. PMID: 19538992

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.

Simoben CV, Robaa D, Chakrabarti A, Schmidtkunz K, Marek M, Lancelot J, Kannan S, Melesina J, Shaik TB, Pierce RJ, Romier C, Jung M, Sippl W. Simoben CV, et al. Molecules. 2018 Mar 2;23(3):566. doi: 10.3390/molecules23030566. Molecules. 2018. PMID: 29498707 Free PMC article.

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.

Stolfa DA, Marek M, Lancelot J, Hauser AT, Walter A, Leproult E, Melesina J, Rumpf T, Wurtz JM, Cavarelli J, Sippl W, Pierce RJ, Romier C, Jung M. Stolfa DA, et al. J Mol Biol. 2014 Oct 9;426(20):3442-53. doi: 10.1016/j.jmb.2014.03.007. Epub 2014 Mar 20. J Mol Biol. 2014. PMID: 24657767 Free article.

Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni.

Marek M, Kannan S, Hauser AT, Moraes Mourão M, Caby S, Cura V, Stolfa DA, Schmidtkunz K, Lancelot J, Andrade L, Renaud JP, Oliveira G, Sippl W, Jung M, Cavarelli J, Pierce RJ, Romier C. Marek M, et al. PLoS Pathog. 2013;9(9):e1003645. doi: 10.1371/journal.ppat.1003645. Epub 2013 Sep 26. PLoS Pathog. 2013. PMID: 24086136 Free PMC article.

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