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Items: 1 to 20 of 96

1.

Serotonin 5-HT1A Receptor Biased Agonists Induce Different Cerebral Metabolic Responses: A [18F]-Fluorodesoxyglucose Positron Emission Tomography Study in Conscious and Anesthetized Rats.

Levigoureux E, Vidal B, Fieux S, Bouillot C, Emery S, Newman-Tancredi A, Zimmer L.

ACS Chem Neurosci. 2019 Jul 17;10(7):3108-3119. doi: 10.1021/acschemneuro.8b00584. Epub 2019 Jan 7.

PMID:
30576601
2.

In vivo biased agonism at 5-HT1A receptors: characterisation by simultaneous PET/MR imaging.

Vidal B, Fieux S, Redouté J, Villien M, Bonnefoi F, Le Bars D, Newman-Tancredi A, Costes N, Zimmer L.

Neuropsychopharmacology. 2018 Oct;43(11):2310-2319. doi: 10.1038/s41386-018-0145-2. Epub 2018 Jul 6.

PMID:
30030540
3.

18F-F13640 preclinical evaluation in rodent, cat and primate as a 5-HT1A receptor agonist for PET neuroimaging.

Vidal B, Fieux S, Colom M, Billard T, Bouillot C, Barret O, Constantinescu C, Tamagnan G, Newman-Tancredi A, Zimmer L.

Brain Struct Funct. 2018 Jul;223(6):2973-2988. doi: 10.1007/s00429-018-1672-7. Epub 2018 May 5.

PMID:
29730825
4.

NLX-112, a novel 5-HT1A receptor agonist for the treatment of L-DOPA-induced dyskinesia: Behavioral and neurochemical profile in rat.

Iderberg H, McCreary AC, Varney MA, Kleven MS, Koek W, Bardin L, Depoortère R, Cenci MA, Newman-Tancredi A.

Exp Neurol. 2015 Sep;271:335-50. doi: 10.1016/j.expneurol.2015.05.021. Epub 2015 May 30.

PMID:
26037043
5.

Marmoset Serotonin 5-HT1A Receptor Mapping with a Biased Agonist PET Probe 18F-F13714: Comparison with an Antagonist Tracer 18F-MPPF in Awake and Anesthetized States.

Yokoyama C, Mawatari A, Kawasaki A, Takeda C, Onoe K, Doi H, Newman-Tancredi A, Zimmer L, Onoe H.

Int J Neuropsychopharmacol. 2016 Dec 30;19(12). pii: pyw079. doi: 10.1093/ijnp/pyw079. Print 2016 Dec.

6.

NLX-112, a highly selective 5-HT1A receptor agonist, mediates analgesia and antidepressant-like activity in rats via spinal cord and prefrontal cortex 5-HT1A receptors, respectively.

Newman-Tancredi A, Bardin L, Auclair A, Colpaert F, Depoortère R, Varney MA.

Brain Res. 2018 Jun 1;1688:1-7. doi: 10.1016/j.brainres.2018.03.016. Epub 2018 Mar 16.

PMID:
29555239
7.

Activity of Serotonin 5-HT1A Receptor Biased Agonists in Rat: Anxiolytic and Antidepressant-like properties.

Jastrzębska-Więsek M, Partyka A, Rychtyk J, Śniecikowska J, Kołaczkowski M, Wesołowska A, Varney MA, Newman-Tancredi A.

ACS Chem Neurosci. 2018 May 16;9(5):1040-1050. doi: 10.1021/acschemneuro.7b00443. Epub 2018 Jan 11.

PMID:
29266914
8.

[18F]F15599, a novel 5-HT1A receptor agonist, as a radioligand for PET neuroimaging.

Lemoine L, Verdurand M, Vacher B, Blanc E, Le Bars D, Newman-Tancredi A, Zimmer L.

Eur J Nucl Med Mol Imaging. 2010 Mar;37(3):594-605. doi: 10.1007/s00259-009-1274-y. Epub 2009 Sep 30.

PMID:
19789870
9.

NLX-112, a highly selective 5-HT1A receptor agonist: Effects on body temperature and plasma corticosterone levels in rats.

Newman-Tancredi A, Depoortère R, Carilla-Durand E, Tarayre JP, Kleven M, Koek W, Bardin L, Varney MA.

Pharmacol Biochem Behav. 2018 Feb;165:56-62. doi: 10.1016/j.pbb.2017.11.002. Epub 2017 Nov 7.

PMID:
29126856
10.

Distinctive in vitro signal transduction profile of NLX-112, a potent and efficacious serotonin 5-HT1A receptor agonist.

Newman-Tancredi A, Martel JC, Cosi C, Heusler P, Lestienne F, Varney MA, Cussac D.

J Pharm Pharmacol. 2017 Sep;69(9):1178-1190. doi: 10.1111/jphp.12762. Epub 2017 Jun 14.

PMID:
28612503
11.

The novel 5-HT1A receptor agonist, NLX-112 reduces l-DOPA-induced abnormal involuntary movements in rat: A chronic administration study with microdialysis measurements.

McCreary AC, Varney MA, Newman-Tancredi A.

Neuropharmacology. 2016 Jun;105:651-660. doi: 10.1016/j.neuropharm.2016.01.013. Epub 2016 Jan 9.

PMID:
26777281
12.

Serotonin 5-HT1A Receptor Biased Agonists Display Differential Anxiolytic Activity in a Rat Social Interaction Model.

Depoortère R, Bardin L, Varney MA, Newman-Tancredi A.

ACS Chem Neurosci. 2019 Jul 17;10(7):3101-3107. doi: 10.1021/acschemneuro.8b00661. Epub 2019 Apr 2.

PMID:
30929419
13.

Effects of the Serotonin 5-HT1A Receptor Biased Agonists, F13714 and F15599, on Striatal Neurotransmitter Levels Following L-DOPA Administration in Hemi-Parkinsonian Rats.

Newman-Tancredi A, Varney MA, McCreary AC.

Neurochem Res. 2018 May;43(5):1035-1046. doi: 10.1007/s11064-018-2514-y. Epub 2018 Mar 23.

PMID:
29572645
14.

3-Chloro-4-[18F]fluorophenyl-(4-fluoro-4-[[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl]-piperidin-1-yl)methanone (F15599).

Leung K.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2012 Jun 20 [updated 2012 Oct 11].

15.

Activity of serotonin 5-HT(1A) receptor 'biased agonists' in rat models of Parkinson's disease and L-DOPA-induced dyskinesia.

Iderberg H, McCreary AC, Varney MA, Cenci MA, Newman-Tancredi A.

Neuropharmacology. 2015 Jun;93:52-67. doi: 10.1016/j.neuropharm.2015.01.012. Epub 2015 Jan 31.

PMID:
25645393
16.

Agonist and antagonist bind differently to 5-HT1A receptors during Alzheimer's disease: A post-mortem study with PET radiopharmaceuticals.

Vidal B, Sebti J, Verdurand M, Fieux S, Billard T, Streichenberger N, Troakes C, Newman-Tancredi A, Zimmer L.

Neuropharmacology. 2016 Oct;109:88-95. doi: 10.1016/j.neuropharm.2016.05.009. Epub 2016 May 13.

PMID:
27183968
17.

Cortical 5-hydroxytryptamine 1A receptor biased agonist, NLX-101, displays rapid-acting antidepressant-like properties in the rat chronic mild stress model.

Depoortère R, Papp M, Gruca P, Lason-Tyburkiewicz M, Niemczyk M, Varney MA, Newman-Tancredi A.

J Psychopharmacol. 2019 Jul 10:269881119860666. doi: 10.1177/0269881119860666. [Epub ahead of print]

PMID:
31290370
18.

Involvement of presynaptic 5-HT1A receptors in the low propensity of brexpiprazole to induce extrapyramidal side effects in rats.

Mombereau C, Arnt J, Mørk A.

Pharmacol Biochem Behav. 2017 Feb;153:141-146. doi: 10.1016/j.pbb.2016.12.015. Epub 2017 Jan 3.

PMID:
28057524
19.

Antinociceptive, antiallodynic and antihyperalgesic effects of the 5-HT1A receptor selective agonist, NLX-112 in mouse models of pain.

Sałat K, Kołaczkowski M, Furgała A, Rojek A, Śniecikowska J, Varney MA, Newman-Tancredi A.

Neuropharmacology. 2017 Oct;125:181-188. doi: 10.1016/j.neuropharm.2017.07.022. Epub 2017 Jul 24.

PMID:
28751195
20.

Radiosynthesis and preclinical evaluation of 18F-F13714 as a fluorinated 5-HT1A receptor agonist radioligand for PET neuroimaging.

Lemoine L, Becker G, Vacher B, Billard T, Lancelot S, Newman-Tancredi A, Zimmer L.

J Nucl Med. 2012 Jun;53(6):969-76. doi: 10.2967/jnumed.111.101212. Epub 2012 May 10.

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