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Items: 1 to 20 of 101

1.

New amyloid beta-disaggregating agents: synthesis, pharmacological evaluation, crystal structure and molecular docking of N-(4-((7-chloroquinolin-4-yl)oxy)-3-ethoxybenzyl)amines.

Umar T, Shalini S, Raza MK, Gusain S, Kumar J, Ahmed W, Tiwari M, Hoda N.

Medchemcomm. 2018 Aug 20;9(11):1891-1904. doi: 10.1039/c8md00312b. eCollection 2018 Nov 1.

PMID:
30568757
2.

Multifunctional novel Diallyl disulfide (DADS) derivatives with β-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer's disease.

Manral A, Saini V, Meena P, Tiwari M.

Bioorg Med Chem. 2015 Oct 1;23(19):6389-403. doi: 10.1016/j.bmc.2015.08.024. Epub 2015 Aug 22.

PMID:
26337018
3.

Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents.

Jameel E, Meena P, Maqbool M, Kumar J, Ahmed W, Mumtazuddin S, Tiwari M, Hoda N, Jayaram B.

Eur J Med Chem. 2017 Aug 18;136:36-51. doi: 10.1016/j.ejmech.2017.04.064. Epub 2017 Apr 24.

PMID:
28478343
4.

Naphthalene-triazolopyrimidine hybrid compounds as potential multifunctional anti-Alzheimer's agents.

Umar T, Gusain S, Raza MK, Shalini S, Kumar J, Tiwari M, Hoda N.

Bioorg Med Chem. 2019 Jun 3. pii: S0968-0896(19)30223-8. doi: 10.1016/j.bmc.2019.06.004. [Epub ahead of print]

PMID:
31176571
5.

A multifunctional therapeutic approach: Synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer's disease.

Umar T, Shalini S, Raza MK, Gusain S, Kumar J, Seth P, Tiwari M, Hoda N.

Eur J Med Chem. 2019 Aug 1;175:2-19. doi: 10.1016/j.ejmech.2019.04.038. Epub 2019 Apr 24.

PMID:
31055149
6.

Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease.

Meena P, Nemaysh V, Khatri M, Manral A, Luthra PM, Tiwari M.

Bioorg Med Chem. 2015 Mar 1;23(5):1135-48. doi: 10.1016/j.bmc.2014.12.057. Epub 2015 Jan 13.

PMID:
25624107
7.

Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.

Mishra CB, Kumari S, Manral A, Prakash A, Saini V, Lynn AM, Tiwari M.

Eur J Med Chem. 2017 Jan 5;125:736-750. doi: 10.1016/j.ejmech.2016.09.057. Epub 2016 Sep 19.

PMID:
27721157
8.

6-Methyluracil derivatives as acetylcholinesterase inhibitors for treatment of Alzheimer's disease.

Zueva IV, Semenov VE, Mukhamedyarov MA, Lushchekina SV, Kharlamova AD, Petukhova EO, Mikhailov AS, Podyachev SN, Saifina LF, Petrov KA, Minnekhanova OA, Zobov VV, Nikolsky EE, Masson P, Reznik VS.

Int J Risk Saf Med. 2015;27 Suppl 1:S69-71. doi: 10.3233/JRS-150694.

PMID:
26639718
9.

Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.

Sang Z, Pan W, Wang K, Ma Q, Yu L, Yang Y, Bai P, Leng C, Xu Q, Li X, Tan Z, Liu W.

Eur J Med Chem. 2017 Apr 21;130:379-392. doi: 10.1016/j.ejmech.2017.02.039. Epub 2017 Feb 20.

PMID:
28279845
10.

Synthesis and characterization of 1H-phenanthro[9,10-d]imidazole derivatives as multifunctional agents for treatment of Alzheimer's disease.

Liu J, Qiu J, Wang M, Wang L, Su L, Gao J, Gu Q, Xu J, Huang SL, Gu LQ, Huang ZS, Li D.

Biochim Biophys Acta. 2014 Sep;1840(9):2886-903. doi: 10.1016/j.bbagen.2014.05.005. Epub 2014 May 10.

PMID:
24821011
11.

Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.

Huang L, Lu C, Sun Y, Mao F, Luo Z, Su T, Jiang H, Shan W, Li X.

J Med Chem. 2012 Oct 11;55(19):8483-92. doi: 10.1021/jm300978h. Epub 2012 Oct 1.

PMID:
22978824
12.

New multi-target-directed small molecules against Alzheimer's disease: a combination of resveratrol and clioquinol.

Mao F, Yan J, Li J, Jia X, Miao H, Sun Y, Huang L, Li X.

Org Biomol Chem. 2014 Aug 21;12(31):5936-44. doi: 10.1039/c4ob00998c.

PMID:
24986600
13.

Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents.

Luo W, Su YB, Hong C, Tian RG, Su LP, Wang YQ, Li Y, Yue JJ, Wang CJ.

Bioorg Med Chem. 2013 Dec 1;21(23):7275-82. doi: 10.1016/j.bmc.2013.09.061. Epub 2013 Oct 4.

PMID:
24148835
14.

Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.

Qiang X, Sang Z, Yuan W, Li Y, Liu Q, Bai P, Shi Y, Ang W, Tan Z, Deng Y.

Eur J Med Chem. 2014 Apr 9;76:314-31. doi: 10.1016/j.ejmech.2014.02.045. Epub 2014 Feb 17.

PMID:
24589487
15.

Design, selection, and characterization of thioflavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease.

Rodríguez-Rodríguez C, Sánchez de Groot N, Rimola A, Alvarez-Larena A, Lloveras V, Vidal-Gancedo J, Ventura S, Vendrell J, Sodupe M, González-Duarte P.

J Am Chem Soc. 2009 Feb 4;131(4):1436-51. doi: 10.1021/ja806062g.

PMID:
19133767
16.

Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease.

Sang Z, Qiang X, Li Y, Yuan W, Liu Q, Shi Y, Ang W, Luo Y, Tan Z, Deng Y.

Eur J Med Chem. 2015 Apr 13;94:348-66. doi: 10.1016/j.ejmech.2015.02.063. Epub 2015 Mar 4.

PMID:
25778991
17.

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.

Panek D, Więckowska A, Wichur T, Bajda M, Godyń J, Jończyk J, Mika K, Janockova J, Soukup O, Knez D, Korabecny J, Gobec S, Malawska B.

Eur J Med Chem. 2017 Jan 5;125:676-695. doi: 10.1016/j.ejmech.2016.09.078. Epub 2016 Sep 26.

PMID:
27721153
18.
19.

Rational Design and Multibiological Profiling of Novel Donepezil-Trolox Hybrids against Alzheimer's Disease, with Cholinergic, Antioxidant, Neuroprotective, and Cognition Enhancing Properties.

Cai P, Fang SQ, Yang XL, Wu JJ, Liu QH, Hong H, Wang XB, Kong LY.

ACS Chem Neurosci. 2017 Nov 15;8(11):2496-2511. doi: 10.1021/acschemneuro.7b00257. Epub 2017 Aug 25.

PMID:
28806057
20.

Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.

Wang ZM, Cai P, Liu QH, Xu DQ, Yang XL, Wu JJ, Kong LY, Wang XB.

Eur J Med Chem. 2016 Nov 10;123:282-297. doi: 10.1016/j.ejmech.2016.07.052. Epub 2016 Jul 25.

PMID:
27484514

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