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Items: 1 to 20 of 119

1.

Acetylation of intrinsically disordered regions regulates phase separation.

Saito M, Hess D, Eglinger J, Fritsch AW, Kreysing M, Weinert BT, Choudhary C, Matthias P.

Nat Chem Biol. 2019 Jan;15(1):51-61. doi: 10.1038/s41589-018-0180-7. Epub 2018 Dec 10.

PMID:
30531905
2.

TAR DNA-binding protein 43 (TDP-43) liquid-liquid phase separation is mediated by just a few aromatic residues.

Li HR, Chiang WC, Chou PC, Wang WJ, Huang JR.

J Biol Chem. 2018 Apr 20;293(16):6090-6098. doi: 10.1074/jbc.AC117.001037. Epub 2018 Mar 6.

3.

Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs.

Lin Y, Currie SL, Rosen MK.

J Biol Chem. 2017 Nov 17;292(46):19110-19120. doi: 10.1074/jbc.M117.800466. Epub 2017 Sep 18.

4.

Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions.

Dao TP, Kolaitis RM, Kim HJ, O'Donovan K, Martyniak B, Colicino E, Hehnly H, Taylor JP, Castañeda CA.

Mol Cell. 2018 Mar 15;69(6):965-978.e6. doi: 10.1016/j.molcel.2018.02.004. Epub 2018 Mar 8.

5.

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.

Boeynaems S, Bogaert E, Kovacs D, Konijnenberg A, Timmerman E, Volkov A, Guharoy M, De Decker M, Jaspers T, Ryan VH, Janke AM, Baatsen P, Vercruysse T, Kolaitis RM, Daelemans D, Taylor JP, Kedersha N, Anderson P, Impens F, Sobott F, Schymkowitz J, Rousseau F, Fawzi NL, Robberecht W, Van Damme P, Tompa P, Van Den Bosch L.

Mol Cell. 2017 Mar 16;65(6):1044-1055.e5. doi: 10.1016/j.molcel.2017.02.013.

6.

Acetylation Disfavors Tau Phase Separation.

Ferreon JC, Jain A, Choi KJ, Tsoi PS, MacKenzie KR, Jung SY, Ferreon AC.

Int J Mol Sci. 2018 May 4;19(5). pii: E1360. doi: 10.3390/ijms19051360.

7.

DEAD-box RNA helicase Belle posttranscriptionally promotes gene expression in an ATPase activity-dependent manner.

Liao SE, Kandasamy SK, Zhu L, Fukunaga R.

RNA. 2019 Jul;25(7):825-839. doi: 10.1261/rna.070268.118. Epub 2019 Apr 12.

PMID:
30979781
8.

Distinct stages in stress granule assembly and disassembly.

Wheeler JR, Matheny T, Jain S, Abrisch R, Parker R.

Elife. 2016 Sep 7;5. pii: e18413. doi: 10.7554/eLife.18413.

9.

Why Do Disordered and Structured Proteins Behave Differently in Phase Separation?

Zhou HX, Nguemaha V, Mazarakos K, Qin S.

Trends Biochem Sci. 2018 Jul;43(7):499-516. doi: 10.1016/j.tibs.2018.03.007. Epub 2018 Apr 30. Review.

10.

Temperature, Hydrostatic Pressure, and Osmolyte Effects on Liquid-Liquid Phase Separation in Protein Condensates: Physical Chemistry and Biological Implications.

Cinar H, Fetahaj Z, Cinar S, Vernon RM, Chan HS, Winter RHA.

Chemistry. 2019 Oct 11;25(57):13049-13069. doi: 10.1002/chem.201902210. Epub 2019 Aug 22. Review.

PMID:
31237369
11.

Single-molecule fluorescence studies of intrinsically disordered proteins and liquid phase separation.

Nasir I, Onuchic PL, Labra SR, Deniz AA.

Biochim Biophys Acta Proteins Proteom. 2019 Oct;1867(10):980-987. doi: 10.1016/j.bbapap.2019.04.007. Epub 2019 May 2. Review.

12.

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins.

Lin Y, Protter DS, Rosen MK, Parker R.

Mol Cell. 2015 Oct 15;60(2):208-19. doi: 10.1016/j.molcel.2015.08.018. Epub 2015 Sep 24.

13.

Dynamic Interaction of Stress Granules, DDX3X, and IKK-α Mediates Multiple Functions in Hepatitis C Virus Infection.

Pène V, Li Q, Sodroski C, Hsu CS, Liang TJ.

J Virol. 2015 May;89(10):5462-77. doi: 10.1128/JVI.03197-14. Epub 2015 Mar 4.

14.
15.

Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells.

Iaconelli J, Lalonde J, Watmuff B, Liu B, Mazitschek R, Haggarty SJ, Karmacharya R.

ACS Chem Biol. 2017 Aug 18;12(8):2139-2148. doi: 10.1021/acschembio.6b01014. Epub 2017 Jul 10.

16.

RNAs, Phase Separation, and Membrane-Less Organelles: Are Post-Transcriptional Modifications Modulating Organelle Dynamics?

Drino A, Schaefer MR.

Bioessays. 2018 Dec;40(12):e1800085. doi: 10.1002/bies.201800085. Epub 2018 Oct 29. Review.

PMID:
30370622
17.

Methods and Strategies to Quantify Phase Separation of Disordered Proteins.

Ceballos AV, McDonald CJ, Elbaum-Garfinkle S.

Methods Enzymol. 2018;611:31-50. doi: 10.1016/bs.mie.2018.09.037. Epub 2018 Nov 3.

18.

Intrinsically Disordered Proteome of Human Membrane-Less Organelles.

Darling AL, Liu Y, Oldfield CJ, Uversky VN.

Proteomics. 2018 Mar;18(5-6):e1700193. doi: 10.1002/pmic.201700193. Epub 2017 Dec 21. Review.

PMID:
29068531
19.

Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation.

Valentin-Vega YA, Wang YD, Parker M, Patmore DM, Kanagaraj A, Moore J, Rusch M, Finkelstein D, Ellison DW, Gilbertson RJ, Zhang J, Kim HJ, Taylor JP.

Sci Rep. 2016 May 16;6:25996. doi: 10.1038/srep25996.

20.

Intrinsically Disordered Protein Ntr2 Modulates the Spliceosomal RNA Helicase Brr2.

Wollenhaupt J, Henning LM, Sticht J, Becke C, Freund C, Santos KF, Wahl MC.

Biophys J. 2018 Feb 27;114(4):788-799. doi: 10.1016/j.bpj.2017.12.033.

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