Similar articles for PMID: 30457860

Year	Number of Results
2004	2
2005	1
2006	2
2008	2
2010	4
2011	7
2012	2
2013	5
2014	8
2015	10
2016	9
2017	7
2018	15
2019	15
2020	24
2021	23
2022	15
2023	8
2024	0

1

Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2.

Wu X, Xu G, Li X, Xu W, Li Q, Liu W, Kirby KA, Loh ML, Li J, Sarafianos SG, Qu CK. Wu X, et al. J Med Chem. 2019 Feb 14;62(3):1125-1137. doi: 10.1021/acs.jmedchem.8b00513. Epub 2018 Dec 5. J Med Chem. 2019. PMID: 30457860 Free PMC article.

2

Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies.

Yu B, Liu W, Yu WM, Loh ML, Alter S, Guvench O, Mackerell AD Jr, Tang LD, Qu CK. Yu B, et al. Mol Cancer Ther. 2013 Sep;12(9):1738-48. doi: 10.1158/1535-7163.MCT-13-0049-T. Epub 2013 Jul 3. Mol Cancer Ther. 2013. PMID: 23825065 Free PMC article.

3

Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).

Liu W, Yu B, Xu G, Xu WR, Loh ML, Tang LD, Qu CK. Liu W, et al. J Med Chem. 2013 Sep 26;56(18):7212-21. doi: 10.1021/jm400474r. Epub 2013 Sep 4. J Med Chem. 2013. PMID: 23957426 Free PMC article.

4

Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).

Zhang X, He Y, Liu S, Yu Z, Jiang ZX, Yang Z, Dong Y, Nabinger SC, Wu L, Gunawan AM, Wang L, Chan RJ, Zhang ZY. Zhang X, et al. J Med Chem. 2010 Mar 25;53(6):2482-93. doi: 10.1021/jm901645u. J Med Chem. 2010. PMID: 20170098 Free PMC article.

5

Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.

Yu ZH, Chen L, Wu L, Liu S, Wang L, Zhang ZY. Yu ZH, et al. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4238-42. doi: 10.1016/j.bmcl.2011.05.078. Epub 2011 May 30. Bioorg Med Chem Lett. 2011. PMID: 21669525 Free PMC article.

6

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.

Chen YN, LaMarche MJ, Chan HM, Fekkes P, Garcia-Fortanet J, Acker MG, Antonakos B, Chen CH, Chen Z, Cooke VG, Dobson JR, Deng Z, Fei F, Firestone B, Fodor M, Fridrich C, Gao H, Grunenfelder D, Hao HX, Jacob J, Ho S, Hsiao K, Kang ZB, Karki R, Kato M, Larrow J, La Bonte LR, Lenoir F, Liu G, Liu S, Majumdar D, Meyer MJ, Palermo M, Perez L, Pu M, Price E, Quinn C, Shakya S, Shultz MD, Slisz J, Venkatesan K, Wang P, Warmuth M, Williams S, Yang G, Yuan J, Zhang JH, Zhu P, Ramsey T, Keen NJ, Sellers WR, Stams T, Fortin PD. Chen YN, et al. Nature. 2016 Jul 7;535(7610):148-52. doi: 10.1038/nature18621. Epub 2016 Jun 29. Nature. 2016. PMID: 27362227

7

Design, synthesis and biological evaluation of pyridine derivatives as selective SHP2 inhibitors.

Liu WS, Yang B, Wang RR, Li WY, Ma YC, Zhou L, Du S, Ma Y, Wang RL. Liu WS, et al. Bioorg Chem. 2020 Jul;100:103875. doi: 10.1016/j.bioorg.2020.103875. Epub 2020 Apr 25. Bioorg Chem. 2020. PMID: 32380342

8

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.

Garcia Fortanet J, Chen CH, Chen YN, Chen Z, Deng Z, Firestone B, Fekkes P, Fodor M, Fortin PD, Fridrich C, Grunenfelder D, Ho S, Kang ZB, Karki R, Kato M, Keen N, LaBonte LR, Larrow J, Lenoir F, Liu G, Liu S, Lombardo F, Majumdar D, Meyer MJ, Palermo M, Perez L, Pu M, Ramsey T, Sellers WR, Shultz MD, Stams T, Towler C, Wang P, Williams SL, Zhang JH, LaMarche MJ. Garcia Fortanet J, et al. J Med Chem. 2016 Sep 8;59(17):7773-82. doi: 10.1021/acs.jmedchem.6b00680. Epub 2016 Jul 12. J Med Chem. 2016. PMID: 27347692

9

Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo.

Grosskopf S, Eckert C, Arkona C, Radetzki S, Böhm K, Heinemann U, Wolber G, von Kries JP, Birchmeier W, Rademann J. Grosskopf S, et al. ChemMedChem. 2015 May;10(5):815-26. doi: 10.1002/cmdc.201500015. Epub 2015 Apr 15. ChemMedChem. 2015. PMID: 25877780

10

Identification of demethylincisterol A₃ as a selective inhibitor of protein tyrosine phosphatase Shp2.

Chen C, Liang F, Chen B, Sun Z, Xue T, Yang R, Luo D. Chen C, et al. Eur J Pharmacol. 2017 Jan 15;795:124-133. doi: 10.1016/j.ejphar.2016.12.012. Epub 2016 Dec 8. Eur J Pharmacol. 2017. PMID: 27939989

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