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Items: 1 to 20 of 89


Discovery of a novel azetidine scaffold for colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors by the use of docking models.

Ikegashira K, Ikenogami T, Yamasaki T, Hase Y, Yamaguchi T, Inagaki K, Doi S, Adachi T, Koga Y, Hashimoto H.

Bioorg Med Chem Lett. 2019 Jan 1;29(1):115-118. doi: 10.1016/j.bmcl.2018.10.051. Epub 2018 Nov 1.


Optimization of an azetidine series as inhibitors of colony stimulating factor-1 receptor (CSF-1R) Type II to lead to the clinical candidate JTE-952.

Ikegashira K, Ikenogami T, Yamasaki T, Oka T, Hase Y, Miyagawa N, Inagaki K, Kawahara I, Koga Y, Hashimoto H.

Bioorg Med Chem Lett. 2019 Apr 1;29(7):873-877. doi: 10.1016/j.bmcl.2019.02.006. Epub 2019 Feb 7.


Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.

Meyers MJ, Pelc M, Kamtekar S, Day J, Poda GI, Hall MK, Michener ML, Reitz BA, Mathis KJ, Pierce BS, Parikh MD, Mischke DA, Long SA, Parlow JJ, Anderson DR, Thorarensen A.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1543-7. doi: 10.1016/j.bmcl.2010.01.078. Epub 2010 Jan 21.


Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors.

Guo J, Marcotte PA, McCall JO, Dai Y, Pease LJ, Michaelides MR, Davidsen SK, Glaser KB.

Mol Cancer Ther. 2006 Apr;5(4):1007-13.


Recent advances in colony stimulating factor-1 receptor/c-FMS as an emerging target for various therapeutic implications.

Kumari A, Silakari O, Singh RK.

Biomed Pharmacother. 2018 Jul;103:662-679. doi: 10.1016/j.biopha.2018.04.046. Epub 2018 Apr 24. Review.


Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors.

Schubert C, Schalk-Hihi C, Struble GT, Ma HC, Petrounia IP, Brandt B, Deckman IC, Patch RJ, Player MR, Spurlino JC, Springer BA.

J Biol Chem. 2007 Feb 9;282(6):4094-101. Epub 2006 Nov 28.


Cloning and expression of porcine Colony Stimulating Factor-1 (CSF-1) and Colony Stimulating Factor-1 Receptor (CSF-1R) and analysis of the species specificity of stimulation by CSF-1 and Interleukin 34.

Gow DJ, Garceau V, Kapetanovic R, Sester DP, Fici GJ, Shelly JA, Wilson TL, Hume DA.

Cytokine. 2012 Dec;60(3):793-805. doi: 10.1016/j.cyto.2012.08.008. Epub 2012 Sep 10.


Structural features of the colony-stimulating factor 1 receptor that affect its association with phosphatidylinositol 3-kinase.

Shurtleff SA, Downing JR, Rock CO, Hawkins SA, Roussel MF, Sherr CJ.

EMBO J. 1990 Aug;9(8):2415-21.


Colony-Stimulating Factor-1 Receptor Is Required for Nurse-like Cell Survival in Chronic Lymphocytic Leukemia.

Polk A, Lu Y, Wang T, Seymour E, Bailey NG, Singer JW, Boonstra PS, Lim MS, Malek S, Wilcox RA.

Clin Cancer Res. 2016 Dec 15;22(24):6118-6128. Epub 2016 Jun 22.


Independent regulation of invasion and anchorage-independent growth by different autophosphorylation sites of the macrophage colony-stimulating factor 1 receptor.

Sapi E, Flick MB, Rodov S, Gilmore-Hebert M, Kelley M, Rockwell S, Kacinski BM.

Cancer Res. 1996 Dec 15;56(24):5704-12.


Prostaglandin E2 transactivates the colony-stimulating factor-1 receptor and synergizes with colony-stimulating factor-1 in the induction of macrophage migration via the mitogen-activated protein kinase ERK1/2.

Digiacomo G, Ziche M, Dello Sbarba P, Donnini S, Rovida E.

FASEB J. 2015 Jun;29(6):2545-54. doi: 10.1096/fj.14-258939. Epub 2015 Mar 10.


Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling.

Hume DA, MacDonald KP.

Blood. 2012 Feb 23;119(8):1810-20. doi: 10.1182/blood-2011-09-379214. Epub 2011 Dec 20. Review.


CSF-1R up-regulation is associated with response to pharmacotherapy targeting tyrosine kinase activity in AML cell lines.

Kogan M, Fischer-Smith T, Kaminsky R, Lehmicke G, Rappaport J.

Anticancer Res. 2012 Mar;32(3):893-9.


Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor.

Felix J, Elegheert J, Gutsche I, Shkumatov AV, Wen Y, Bracke N, Pannecoucke E, Vandenberghe I, Devreese B, Svergun DI, Pauwels E, Vergauwen B, Savvides SN.

Structure. 2013 Apr 2;21(4):528-39. doi: 10.1016/j.str.2013.01.018. Epub 2013 Mar 7.


Osteosarcoma cell-intrinsic colony stimulating factor-1 receptor functions to promote tumor cell metastasis through JAG1 signaling.

Wen ZQ, Li XG, Zhang YJ, Ling ZH, Lin XJ.

Am J Cancer Res. 2017 Apr 1;7(4):801-815. eCollection 2017.


Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R.

Ma X, Lin WY, Chen Y, Stawicki S, Mukhyala K, Wu Y, Martin F, Bazan JF, Starovasnik MA.

Structure. 2012 Apr 4;20(4):676-87. doi: 10.1016/j.str.2012.02.010. Epub 2012 Apr 3.


Studies on Colony Stimulating Factor Receptor-1 and Ligands Colony Stimulating Factor-1 and Interleukin-34 in Alzheimer's Disease Brains and Human Microglia.

Walker DG, Tang TM, Lue LF.

Front Aging Neurosci. 2017 Aug 9;9:244. doi: 10.3389/fnagi.2017.00244. eCollection 2017.


Colony-stimulating factor-1 (CSF-1) directly inhibits receptor activator of nuclear factor-{kappa}B ligand (RANKL) expression by osteoblasts.

Wittrant Y, Gorin Y, Mohan S, Wagner B, Abboud-Werner SL.

Endocrinology. 2009 Nov;150(11):4977-88. doi: 10.1210/en.2009-0248. Epub 2009 Oct 9.


Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling.

Coniglio SJ, Eugenin E, Dobrenis K, Stanley ER, West BL, Symons MH, Segall JE.

Mol Med. 2012 May 9;18:519-27. doi: 10.2119/molmed.2011.00217.

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