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Items: 1 to 20 of 102


Generation of Highly Efficient Equine-Derived Antibodies for Post-Exposure Treatment of Ricin Intoxications by Vaccination with Monomerized Ricin.

Falach R, Sapoznikov A, Alcalay R, Aftalion M, Ehrlich S, Makovitzki A, Agami A, Mimran A, Rosner A, Sabo T, Kronman C, Gal Y.

Toxins (Basel). 2018 Nov 12;10(11). pii: E466. doi: 10.3390/toxins10110466.


Isolation of Anti-Ricin Protective Antibodies Exhibiting High Affinity from Immunized Non-Human Primates.

Noy-Porat T, Rosenfeld R, Ariel N, Epstein E, Alcalay R, Zvi A, Kronman C, Ordentlich A, Mazor O.

Toxins (Basel). 2016 Mar 3;8(3). pii: E64. doi: 10.3390/toxins8030064.


Antibody/doxycycline combined therapy for pulmonary ricinosis: Attenuation of inflammation improves survival of ricin-intoxicated mice.

Gal Y, Mazor O, Alcalay R, Seliger N, Aftalion M, Sapoznikov A, Falach R, Kronman C, Sabo T.

Toxicol Rep. 2014 Aug 1;1:496-504. doi: 10.1016/j.toxrep.2014.07.013. eCollection 2014.


Production, Characterisation and Testing of an Ovine Antitoxin against Ricin; Efficacy, Potency and Mechanisms of Action.

Whitfield SJC, Griffiths GD, Jenner DC, Gwyther RJ, Stahl FM, Cork LJ, Holley JL, Green AC, Clark GC.

Toxins (Basel). 2017 Oct 18;9(10). pii: E329. doi: 10.3390/toxins9100329.


Treatments for Pulmonary Ricin Intoxication: Current Aspects and Future Prospects.

Gal Y, Mazor O, Falach R, Sapoznikov A, Kronman C, Sabo T.

Toxins (Basel). 2017 Oct 3;9(10). pii: E311. doi: 10.3390/toxins9100311. Review.


Stability of isolated antibody-antigen complexes as a predictive tool for selecting toxin neutralizing antibodies.

Legler PM, Compton JR, Hale ML, Anderson GP, Olson MA, Millard CB, Goldman ER.

MAbs. 2017 Jan;9(1):43-57. doi: 10.1080/19420862.2016.1236882. Epub 2016 Sep 23.


Intranasal Immunization with Influenza Virus-Like Particles Containing Membrane-Anchored Cholera Toxin B or Ricin Toxin B Enhances Adaptive Immune Responses and Protection against an Antigenically Distinct Virus.

Ji X, Ren Z, Xu N, Meng L, Yu Z, Feng N, Sang X, Li S, Li Y, Wang T, Zhao Y, Wang H, Zheng X, Jin H, Li N, Yang S, Cao J, Liu W, Gao Y, Xia X.

Viruses. 2016 Apr 21;8(4):115. doi: 10.3390/v8040115.


Antibody treatment against pulmonary exposure to abrin confers significantly higher levels of protection than treatment against ricin intoxication.

Sabo T, Gal Y, Elhanany E, Sapoznikov A, Falach R, Mazor O, Kronman C.

Toxicol Lett. 2015 Sep 2;237(2):72-8. doi: 10.1016/j.toxlet.2015.06.003. Epub 2015 Jun 5.


Protective immunity to ricin toxin conferred by antibodies against the toxin's binding subunit (RTB).

Yermakova A, Mantis NJ.

Vaccine. 2011 Oct 19;29(45):7925-35. doi: 10.1016/j.vaccine.2011.08.075. Epub 2011 Aug 26.


Ricin-Holotoxin-Based Vaccines: Induction of Potent Ricin-Neutralizing Antibodies.

Sabo T, Kronman C, Mazor O.

Methods Mol Biol. 2016;1403:683-94. doi: 10.1007/978-1-4939-3387-7_38.


Extended therapeutic window for post-exposure treatment of ricin intoxication conferred by the use of high-affinity antibodies.

Noy-Porat T, Alcalay R, Epstein E, Sabo T, Kronman C, Mazor O.

Toxicon. 2017 Mar 1;127:100-105. doi: 10.1016/j.toxicon.2017.01.009. Epub 2017 Jan 12.


Strong protection against ricin challenge induced by a novel modified ricin A-chain protein in mouse model.

Zhang T, Yang H, Kang L, Gao S, Xin W, Yao W, Zhuang X, Ji B, Wang J.

Hum Vaccin Immunother. 2015;11(7):1779-87. doi: 10.1080/21645515.2015.1038446.


Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection.

Roy CJ, Brey RN, Mantis NJ, Mapes K, Pop IV, Pop LM, Ruback S, Killeen SZ, Doyle-Meyers L, Vinet-Oliphant HS, Didier PJ, Vitetta ES.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3782-7. doi: 10.1073/pnas.1502585112. Epub 2015 Mar 9.


Differential neutralizing activities of a single domain camelid antibody (VHH) specific for ricin toxin's binding subunit (RTB).

Herrera C, Vance DJ, Eisele LE, Shoemaker CB, Mantis NJ.

PLoS One. 2014 Jun 11;9(6):e99788. doi: 10.1371/journal.pone.0099788. eCollection 2014.


Monoclonal antibody, mAb 4C13, an effective detoxicant antibody against ricin poisoning.

Dong N, Luo L, Wu J, Jia P, Li Q, Wang Y, Gao Z, Peng H, Lv M, Huang C, Feng J, Li H, Shan J, Han G, Shen B.

Vaccine. 2015 Jul 31;33(32):3836-42. doi: 10.1016/j.vaccine.2015.06.096. Epub 2015 Jun 30.


High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Nonneutralizing Single-Domain Antibodies on the Enzymatic and Binding Subunits of Ricin Toxin.

Vance DJ, Tremblay JM, Rong Y, Angalakurthi SK, Volkin DB, Middaugh CR, Weis DD, Shoemaker CB, Mantis NJ.

Clin Vaccine Immunol. 2017 Dec 5;24(12). pii: e00236-17. doi: 10.1128/CVI.00236-17. Print 2017 Dec.


A monoclonal immunoglobulin G antibody directed against an immunodominant linear epitope on the ricin A chain confers systemic and mucosal immunity to ricin.

Neal LM, O'Hara J, Brey RN 3rd, Mantis NJ.

Infect Immun. 2010 Jan;78(1):552-61. doi: 10.1128/IAI.00796-09. Epub 2009 Oct 26.


Ricinus communis intoxications in human and veterinary medicine-a summary of real cases.

Worbs S, Köhler K, Pauly D, Avondet MA, Schaer M, Dorner MB, Dorner BG.

Toxins (Basel). 2011 Oct;3(10):1332-72. doi: 10.3390/toxins3101332. Epub 2011 Oct 24. Review.


Characterization and epitope mapping of the polyclonal antibody repertoire elicited by ricin holotoxin-based vaccination.

Cohen O, Mechaly A, Sabo T, Alcalay R, Aloni-Grinstein R, Seliger N, Kronman C, Mazor O.

Clin Vaccine Immunol. 2014 Nov;21(11):1534-40. doi: 10.1128/CVI.00510-14. Epub 2014 Sep 10.


Neutralizing monoclonal antibodies against ricin's enzymatic subunit interfere with protein disulfide isomerase-mediated reduction of ricin holotoxin in vitro.

O'Hara JM, Mantis NJ.

J Immunol Methods. 2013 Sep 30;395(1-2):71-8. doi: 10.1016/j.jim.2013.06.004. Epub 2013 Jun 15.

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