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Items: 1 to 20 of 100

1.

Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma.

Stafford JM, Lee CH, Voigt P, Descostes N, Saldaña-Meyer R, Yu JR, Leroy G, Oksuz O, Chapman JR, Suarez F, Modrek AS, Bayin NS, Placantonakis DG, Karajannis MA, Snuderl M, Ueberheide B, Reinberg D.

Sci Adv. 2018 Oct 31;4(10):eaau5935. doi: 10.1126/sciadv.aau5935. eCollection 2018 Oct.

2.

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas.

Piunti A, Hashizume R, Morgan MA, Bartom ET, Horbinski CM, Marshall SA, Rendleman EJ, Ma Q, Takahashi YH, Woodfin AR, Misharin AV, Abshiru NA, Lulla RR, Saratsis AM, Kelleher NL, James CD, Shilatifard A.

Nat Med. 2017 Apr;23(4):493-500. doi: 10.1038/nm.4296. Epub 2017 Feb 27.

3.

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.

Mohammad F, Weissmann S, Leblanc B, Pandey DP, Højfeldt JW, Comet I, Zheng C, Johansen JV, Rapin N, Porse BT, Tvardovskiy A, Jensen ON, Olaciregui NG, Lavarino C, Suñol M, de Torres C, Mora J, Carcaboso AM, Helin K.

Nat Med. 2017 Apr;23(4):483-492. doi: 10.1038/nm.4293. Epub 2017 Feb 27.

PMID:
28263309
4.

Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma.

Lee CH, Yu JR, Granat J, Saldaña-Meyer R, Andrade J, LeRoy G, Jin Y, Lund P, Stafford JM, Garcia BA, Ueberheide B, Reinberg D.

Genes Dev. 2019 Sep 5. doi: 10.1101/gad.328773.119. [Epub ahead of print]

PMID:
31488577
5.

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.

Harutyunyan AS, Krug B, Chen H, Papillon-Cavanagh S, Zeinieh M, De Jay N, Deshmukh S, Chen CCL, Belle J, Mikael LG, Marchione DM, Li R, Nikbakht H, Hu B, Cagnone G, Cheung WA, Mohammadnia A, Bechet D, Faury D, McConechy MK, Pathania M, Jain SU, Ellezam B, Weil AG, Montpetit A, Salomoni P, Pastinen T, Lu C, Lewis PW, Garcia BA, Kleinman CL, Jabado N, Majewski J.

Nat Commun. 2019 Mar 19;10(1):1262. doi: 10.1038/s41467-019-09140-x.

6.

Current Murine Models and New Developments in H3K27M Diffuse Midline Gliomas.

Welby JP, Kaptzan T, Wohl A, Peterson TE, Raghunathan A, Brown DA, Gupta SK, Zhang L, Daniels DJ.

Front Oncol. 2019 Feb 27;9:92. doi: 10.3389/fonc.2019.00092. eCollection 2019.

7.

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.

Justin N, Zhang Y, Tarricone C, Martin SR, Chen S, Underwood E, De Marco V, Haire LF, Walker PA, Reinberg D, Wilson JR, Gamblin SJ.

Nat Commun. 2016 Apr 28;7:11316. doi: 10.1038/ncomms11316.

8.

Detection of histone H3 K27M mutation and post-translational modifications in pediatric diffuse midline glioma via tissue immunohistochemistry informs diagnosis and clinical outcomes.

Huang T, Garcia R, Qi J, Lulla R, Horbinski C, Behdad A, Wadhwani N, Shilatifard A, James C, Saratsis AM.

Oncotarget. 2018 Dec 14;9(98):37112-37124. doi: 10.18632/oncotarget.26430. eCollection 2018 Dec 14. Erratum in: Oncotarget. 2019 Apr 12;10(28):2788.

9.

CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.

Piunti A, Smith ER, Morgan MAJ, Ugarenko M, Khaltyan N, Helmin KA, Ryan CA, Murray DC, Rickels RA, Yilmaz BD, Rendleman EJ, Savas JN, Singer BD, Bulun SE, Shilatifard A.

Sci Adv. 2019 Jul 3;5(7):eaax2887. doi: 10.1126/sciadv.aax2887. eCollection 2019 Jul.

10.

Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling.

Herz HM, Morgan M, Gao X, Jackson J, Rickels R, Swanson SK, Florens L, Washburn MP, Eissenberg JC, Shilatifard A.

Science. 2014 Aug 29;345(6200):1065-70. doi: 10.1126/science.1255104.

11.

In silico analysis of histone H3 gene expression during human brain development.

Ren M, van Nocker S.

Int J Dev Biol. 2016;60(4-6):167-73. doi: 10.1387/ijdb.150334sv.

12.

Impact of the H3K27M mutation on survival in pediatric high-grade glioma: a systematic review and meta-analysis.

Lu VM, Alvi MA, McDonald KL, Daniels DJ.

J Neurosurg Pediatr. 2018 Nov 30;23(3):308-316. doi: 10.3171/2018.9.PEDS18419. Review.

PMID:
30544362
13.

Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.

Lewis PW, Müller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ, Allis CD.

Science. 2013 May 17;340(6134):857-61. doi: 10.1126/science.1232245. Epub 2013 Mar 28.

14.

Histone H3 Mutations in Cancer.

Wan YCE, Liu J, Chan KM.

Curr Pharmacol Rep. 2018;4(4):292-300. doi: 10.1007/s40495-018-0141-6. Epub 2018 Apr 26. Review.

15.

Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA.

Wang X, Paucek RD, Gooding AR, Brown ZZ, Ge EJ, Muir TW, Cech TR.

Nat Struct Mol Biol. 2017 Dec;24(12):1028-1038. doi: 10.1038/nsmb.3487. Epub 2017 Oct 23.

16.

Diffuse intrinsic pontine gliomas-current management and new biologic insights. Is there a glimmer of hope?

Cohen KJ, Jabado N, Grill J.

Neuro Oncol. 2017 Aug 1;19(8):1025-1034. doi: 10.1093/neuonc/nox021. Review.

17.

Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.

Sanulli S, Justin N, Teissandier A, Ancelin K, Portoso M, Caron M, Michaud A, Lombard B, da Rocha ST, Offer J, Loew D, Servant N, Wassef M, Burlina F, Gamblin SJ, Heard E, Margueron R.

Mol Cell. 2015 Mar 5;57(5):769-783. doi: 10.1016/j.molcel.2014.12.020. Epub 2015 Jan 22.

18.

Identification of Novel RAS Signaling Therapeutic Vulnerabilities in Diffuse Intrinsic Pontine Gliomas.

Koncar RF, Dey BR, Stanton AJ, Agrawal N, Wassell ML, McCarl LH, Locke AL, Sanders L, Morozova-Vaske O, Myers MI, Hamilton RL, Carcaboso AM, Kohanbash G, Hu B, Amankulor NM, Felker J, Kambhampati M, Nazarian J, Becher OJ, James CD, Hashizume R, Broniscer A, Pollack IF, Agnihotri S.

Cancer Res. 2019 Aug 15;79(16):4026-4041. doi: 10.1158/0008-5472.CAN-18-3521. Epub 2019 Jun 14.

PMID:
31201162
19.

Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27.

Zhang Y, Yang X, Gui B, Xie G, Zhang D, Shang Y, Liang J.

J Biol Chem. 2011 Dec 9;286(49):42414-25. doi: 10.1074/jbc.M111.271064. Epub 2011 Oct 17.

20.

Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability.

Zhang Y, Chang JF, Sun J, Chen L, Yang XM, Tang HY, Jing YY, Kang X, He ZM, Wu JY, Wei HM, Wang DL, Xu RG, Zhu RB, Shen Y, Zeng SY, Wang C, Liu KN, Zhang Y, Mao ZY, Jiang CZ, Sun FL.

J Cell Sci. 2018 Jun 21;131(12). pii: jcs215525. doi: 10.1242/jcs.215525.

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