Similar articles for PMID: 30389826

Year	Number of Results
2002	1
2003	5
2004	2
2005	6
2006	2
2007	1
2008	3
2009	1
2010	7
2011	5
2012	10
2013	17
2014	18
2015	14
2016	14
2017	14
2018	21
2019	28
2020	21
2021	20
2022	10
2023	4
2024	0

1

Biased agonism and allosteric modulation of metabotropic glutamate receptor 5.

Trinh PNH, May LT, Leach K, Gregory KJ. Trinh PNH, et al. Clin Sci (Lond). 2018 Nov 2;132(21):2323-2338. doi: 10.1042/CS20180374. Print 2018 Nov 15. Clin Sci (Lond). 2018. PMID: 30389826 Review.

2

Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery.

Sengmany K, Singh J, Stewart GD, Conn PJ, Christopoulos A, Gregory KJ. Sengmany K, et al. Neuropharmacology. 2017 Mar 15;115:60-72. doi: 10.1016/j.neuropharm.2016.07.001. Epub 2016 Jul 5. Neuropharmacology. 2017. PMID: 27392634 Free PMC article.

3

Probe dependence and biased potentiation of metabotropic glutamate receptor 5 is mediated by differential ligand interactions in the common allosteric binding site.

Hellyer SD, Sengmany K, Keller AN, Christopoulos A, Leach K, Gregory KJ. Hellyer SD, et al. Biochem Pharmacol. 2020 Jul;177:114013. doi: 10.1016/j.bcp.2020.114013. Epub 2020 May 8. Biochem Pharmacol. 2020. PMID: 32389635

4

Differential contribution of metabotropic glutamate receptor 5 common allosteric binding site residues to biased allosteric agonism.

Sengmany K, Hellyer SD, Christopoulos A, Lapinsky DJ, Leach K, Gregory KJ. Sengmany K, et al. Biochem Pharmacol. 2020 Jul;177:114011. doi: 10.1016/j.bcp.2020.114011. Epub 2020 May 5. Biochem Pharmacol. 2020. PMID: 32380090

5

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology.

Sengmany K, Hellyer SD, Albold S, Wang T, Conn PJ, May LT, Christopoulos A, Leach K, Gregory KJ. Sengmany K, et al. Neuropharmacology. 2019 May 1;149:83-96. doi: 10.1016/j.neuropharm.2019.02.005. Epub 2019 Feb 11. Neuropharmacology. 2019. PMID: 30763654 Free PMC article.

6

Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5.

Chen ANY, Hellyer SD, Trinh PNH, Leach K, Gregory KJ. Chen ANY, et al. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6:104-115. doi: 10.1111/bcpt.13239. Epub 2019 May 7. Basic Clin Pharmacol Toxicol. 2020. PMID: 30983151 Free article.

7

Metabotropic glutamate receptor 5 (mGlu₅ )-positive allosteric modulators differentially induce or potentiate desensitization of mGlu₅ signaling in recombinant cells and neurons.

Hellyer SD, Albold S, Sengmany K, Singh J, Leach K, Gregory KJ. Hellyer SD, et al. J Neurochem. 2019 Nov;151(3):301-315. doi: 10.1111/jnc.14844. Epub 2019 Aug 26. J Neurochem. 2019. PMID: 31376155 Free article.

8

Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding.

Butkiewicz M, Rodriguez AL, Rainey SE, Wieting J, Luscombe VB, Stauffer SR, Lindsley CW, Conn PJ, Meiler J. Butkiewicz M, et al. ACS Chem Neurosci. 2019 Aug 21;10(8):3427-3436. doi: 10.1021/acschemneuro.8b00227. Epub 2019 Jun 17. ACS Chem Neurosci. 2019. PMID: 31132237 Free PMC article.

9

Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.

Rook JM, Noetzel MJ, Pouliot WA, Bridges TM, Vinson PN, Cho HP, Zhou Y, Gogliotti RD, Manka JT, Gregory KJ, Stauffer SR, Dudek FE, Xiang Z, Niswender CM, Daniels JS, Jones CK, Lindsley CW, Conn PJ. Rook JM, et al. Biol Psychiatry. 2013 Mar 15;73(6):501-9. doi: 10.1016/j.biopsych.2012.09.012. Epub 2012 Nov 7. Biol Psychiatry. 2013. PMID: 23140665 Free PMC article.

10

Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5 as Tool Compounds to Study Signaling Bias.

Arsova A, Møller TC, Hellyer SD, Vedel L, Foster SR, Hansen JL, Bräuner-Osborne H, Gregory KJ. Arsova A, et al. Mol Pharmacol. 2021 May;99(5):328-341. doi: 10.1124/molpharm.120.000185. Epub 2021 Feb 18. Mol Pharmacol. 2021. PMID: 33602724

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