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Virtual memory CD8 T cells expanded by helminth infection confer broad protection against bacterial infection.

Lin JS, Mohrs K, Szaba FM, Kummer LW, Leadbetter EA, Mohrs M.

Mucosal Immunol. 2019 Jan;12(1):258-264. doi: 10.1038/s41385-018-0100-x. Epub 2018 Oct 25.


Neither primary nor memory immunity to Mycobacterium tuberculosis infection is compromised in mice with chronic enteric helminth infection.

Rafi W, Bhatt K, Gause WC, Salgame P.

Infect Immun. 2015 Mar;83(3):1217-23. doi: 10.1128/IAI.03004-14. Epub 2015 Jan 20.


Cutting Edge: Helminth Coinfection Blocks Effector Differentiation of CD8 T Cells through Alternate Host Th2- and IL-10-Mediated Responses.

Marple A, Wu W, Shah S, Zhao Y, Du P, Gause WC, Yap GS.

J Immunol. 2017 Jan 15;198(2):634-639. doi: 10.4049/jimmunol.1601741. Epub 2016 Dec 12. Erratum in: J Immunol. 2017 Oct 15;199(8):3005.


Coinfection with Heligmosomoides polygyrus fails to establish CD8+ T-cell immunity against Toxoplasma gondii.

Khan IA, Hakak R, Eberle K, Sayles P, Weiss LM, Urban JF Jr.

Infect Immun. 2008 Mar;76(3):1305-13. doi: 10.1128/IAI.01236-07. Epub 2008 Jan 14.


Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection.

Rolot M, Dougall AM, Chetty A, Javaux J, Chen T, Xiao X, Machiels B, Selkirk ME, Maizels RM, Hokke C, Denis O, Brombacher F, Vanderplasschen A, Gillet L, Horsnell WGC, Dewals BG.

Nat Commun. 2018 Oct 30;9(1):4516. doi: 10.1038/s41467-018-06978-5.


Intestinal helminth infection induces highly functional resident memory CD4+ T cells in mice.

Steinfelder S, Rausch S, Michael D, Kühl AA, Hartmann S.

Eur J Immunol. 2017 Feb;47(2):353-363. doi: 10.1002/eji.201646575. Epub 2016 Nov 28.


IL-4 and IL-15 promotion of virtual memory CD8+ T cells is determined by genetic background.

Tripathi P, Morris SC, Perkins C, Sholl A, Finkelman FD, Hildeman DA.

Eur J Immunol. 2016 Oct;46(10):2333-2339. doi: 10.1002/eji.201646404. Epub 2016 Aug 16.


Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.

Hewitson JP, Filbey KJ, Esser-von Bieren J, Camberis M, Schwartz C, Murray J, Reynolds LA, Blair N, Robertson E, Harcus Y, Boon L, Huang SC, Yang L, Tu Y, Miller MJ, Voehringer D, Le Gros G, Harris N, Maizels RM.

PLoS Pathog. 2015 Mar 27;11(3):e1004676. doi: 10.1371/journal.ppat.1004676. eCollection 2015 Mar.


Thymic expression of IL-4 and IL-15 after systemic inflammatory or infectious Th1 disease processes induce the acquisition of "innate" characteristics during CD8+ T cell development.

Baez NS, Cerbán F, Savid-Frontera C, Hodge DL, Tosello J, Acosta-Rodriguez E, Almada L, Gruppi A, Viano ME, Young HA, Rodriguez-Galan MC.

PLoS Pathog. 2019 Jan 4;15(1):e1007456. doi: 10.1371/journal.ppat.1007456. eCollection 2019 Jan.


ITK tunes IL-4-induced development of innate memory CD8+ T cells in a γδ T and invariant NKT cell-independent manner.

Huang W, Huang F, Kannan AK, Hu J, August A.

J Leukoc Biol. 2014 Jul;96(1):55-63. doi: 10.1189/jlb.1AB0913-484RR. Epub 2014 Mar 11.


Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus.

Reynolds LA, Filbey KJ, Maizels RM.

Semin Immunopathol. 2012 Nov;34(6):829-46. doi: 10.1007/s00281-012-0347-3. Epub 2012 Oct 11. Review.


Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion.

Smith KA, Löser S, Varyani F, Harcus Y, McSorley HJ, McKenzie AN, Maizels RM.

Elife. 2018 Sep 21;7. pii: e38269. doi: 10.7554/eLife.38269.


The intestinal nematode inhibits T-cell reactivity by targeting P-GP activity.

Donskow-Łysoniewska K, Krawczak K, Kozłowska E, Doligalska M.

Parasite Immunol. 2017 Dec;39(12). doi: 10.1111/pim.12497.


IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infection.

Pelly VS, Kannan Y, Coomes SM, Entwistle LJ, Rückerl D, Seddon B, MacDonald AS, McKenzie A, Wilson MS.

Mucosal Immunol. 2016 Nov;9(6):1407-1417. doi: 10.1038/mi.2016.4. Epub 2016 Feb 17.


Heligmosomoides polygyrus infection can inhibit colitis through direct interaction with innate immunity.

Hang L, Setiawan T, Blum AM, Urban J, Stoyanoff K, Arihiro S, Reinecker HC, Weinstock JV.

J Immunol. 2010 Sep 15;185(6):3184-9. doi: 10.4049/jimmunol.1000941. Epub 2010 Aug 11.


Critical Role for Interleukin-25 in Host Protective Th2 Memory Response against Heligmosomoides polygyrus bakeri.

Pei C, Zhao C, Wang AJ, Fan AX, Grinchuk V, Smith A, Sun R, Xie Y, Lu N, Urban JF Jr, Shea-Donohue T, Zhao A, Yang Z.

Infect Immun. 2016 Nov 18;84(12):3328-3337. Print 2016 Dec.


Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection.

McCoy KD, Stoel M, Stettler R, Merky P, Fink K, Senn BM, Schaer C, Massacand J, Odermatt B, Oettgen HC, Zinkernagel RM, Bos NA, Hengartner H, Macpherson AJ, Harris NL.

Cell Host Microbe. 2008 Oct 16;4(4):362-73. doi: 10.1016/j.chom.2008.08.014.


MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus.

Reynolds LA, Harcus Y, Smith KA, Webb LM, Hewitson JP, Ross EA, Brown S, Uematsu S, Akira S, Gray D, Gray M, MacDonald AS, Cunningham AF, Maizels RM.

J Immunol. 2014 Sep 15;193(6):2984-93. doi: 10.4049/jimmunol.1401056. Epub 2014 Aug 11.


Immune modulation and modulators in Heligmosomoides polygyrus infection.

Maizels RM, Hewitson JP, Murray J, Harcus YM, Dayer B, Filbey KJ, Grainger JR, McSorley HJ, Reynolds LA, Smith KA.

Exp Parasitol. 2012 Sep;132(1):76-89. doi: 10.1016/j.exppara.2011.08.011. Epub 2011 Aug 22. Review.


IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells.

Coomes SM, Pelly VS, Kannan Y, Okoye IS, Czieso S, Entwistle LJ, Perez-Lloret J, Nikolov N, Potocnik AJ, Biró J, Langhorne J, Wilson MS.

PLoS Pathog. 2015 Jul 6;11(7):e1004994. doi: 10.1371/journal.ppat.1004994. eCollection 2015 Jul.

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