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Items: 1 to 20 of 99

1.

Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR-CHK1, p21, and NF-κB.

Aasland D, Götzinger L, Hauck L, Berte N, Meyer J, Effenberger M, Schneider S, Reuber EE, Roos WP, Tomicic MT, Kaina B, Christmann M.

Cancer Res. 2019 Jan 1;79(1):99-113. doi: 10.1158/0008-5472.CAN-18-1733. Epub 2018 Oct 25.

PMID:
30361254
3.

Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage.

Knizhnik AV, Roos WP, Nikolova T, Quiros S, Tomaszowski KH, Christmann M, Kaina B.

PLoS One. 2013;8(1):e55665. doi: 10.1371/journal.pone.0055665. Epub 2013 Jan 30.

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Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide.

Eich M, Roos WP, Nikolova T, Kaina B.

Mol Cancer Ther. 2013 Nov;12(11):2529-40. doi: 10.1158/1535-7163.MCT-13-0136. Epub 2013 Aug 19.

8.

The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage.

Sfikas A, Batsi C, Tselikou E, Vartholomatos G, Monokrousos N, Pappas P, Christoforidis S, Tzavaras T, Kanavaros P, Gorgoulis VG, Marcu KB, Kolettas E.

Cell Signal. 2012 Nov;24(11):2007-23. doi: 10.1016/j.cellsig.2012.06.010. Epub 2012 Jun 29.

9.

DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system.

Caporali S, Falcinelli S, Starace G, Russo MT, Bonmassar E, Jiricny J, D'Atri S.

Mol Pharmacol. 2004 Sep;66(3):478-91.

PMID:
15322239
10.

Involvement of the mismatch repair system in temozolomide-induced apoptosis.

D'Atri S, Tentori L, Lacal PM, Graziani G, Pagani E, Benincasa E, Zambruno G, Bonmassar E, Jiricny J.

Mol Pharmacol. 1998 Aug;54(2):334-41.

PMID:
9687575
11.

Chk1 and Wee1 control genotoxic-stress induced G2-M arrest in melanoma cells.

Vera J, Raatz Y, Wolkenhauer O, Kottek T, Bhattacharya A, Simon JC, Kunz M.

Cell Signal. 2015 May;27(5):951-60. doi: 10.1016/j.cellsig.2015.01.020. Epub 2015 Feb 12.

PMID:
25683911
12.

Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.

Roos WP, Batista LF, Naumann SC, Wick W, Weller M, Menck CF, Kaina B.

Oncogene. 2007 Jan 11;26(2):186-97. Epub 2006 Jul 3.

PMID:
16819506
13.

Resveratrol abrogates the temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the temozolomide-induced senescence in glioma cells.

Filippi-Chiela EC, Thomé MP, Bueno e Silva MM, Pelegrini AL, Ledur PF, Garicochea B, Zamin LL, Lenz G.

BMC Cancer. 2013 Mar 22;13:147. doi: 10.1186/1471-2407-13-147.

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Diversity of DNA damage response of astrocytes and glioblastoma cell lines with various p53 status to treatment with etoposide and temozolomide.

Sato Y, Kurose A, Ogawa A, Ogasawara K, Traganos F, Darzynkiewicz Z, Sawai T.

Cancer Biol Ther. 2009 Mar;8(5):452-7. Epub 2009 Mar 30.

16.

E2F1-dependent pathways are involved in amonafide analogue 7-d-induced DNA damage, G2/M arrest, and apoptosis in p53-deficient K562 cells.

Li Y, Shao J, Shen K, Xu Y, Liu J, Qian X.

J Cell Biochem. 2012 Oct;113(10):3165-77. doi: 10.1002/jcb.24194.

PMID:
22593008
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Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding.

Yamini B, Yu X, Dolan ME, Wu MH, Darga TE, Kufe DW, Weichselbaum RR.

Cancer Res. 2007 Jul 15;67(14):6889-98. Erratum in: Cancer Res. 2009 Feb 15;69(4):1695. Darga, Thomas E [added].

19.

Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53.

Naumann SC, Roos WP, Jöst E, Belohlavek C, Lennerz V, Schmidt CW, Christmann M, Kaina B.

Br J Cancer. 2009 Jan 27;100(2):322-33. doi: 10.1038/sj.bjc.6604856. Epub 2009 Jan 6.

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