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Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial.

Cooper DJ, Nichol AD, Bailey M, Bernard S, Cameron PA, Pili-Floury S, Forbes A, Gantner D, Higgins AM, Huet O, Kasza J, Murray L, Newby L, Presneill JJ, Rashford S, Rosenfeld JV, Stephenson M, Vallance S, Varma D, Webb SAR, Trapani T, McArthur C; POLAR Trial Investigators and the ANZICS Clinical Trials Group.

JAMA. 2018 Dec 4;320(21):2211-2220. doi: 10.1001/jama.2018.17075.


Statistical analysis plan for the POLAR-RCT: The Prophylactic hypOthermia trial to Lessen trAumatic bRain injury-Randomised Controlled Trial.

Presneill J, Gantner D, Nichol A, McArthur C, Forbes A, Kasza J, Trapani T, Murray L, Bernard S, Cameron P, Capellier G, Huet O, Newby L, Rashford S, Rosenfeld JV, Smith T, Stephenson M, Varma D, Vallance S, Walker T, Webb S, James Cooper D; POLAR investigators and the ANZICS Clinical Trials Group.

Trials. 2018 Apr 27;19(1):259. doi: 10.1186/s13063-018-2610-y.


Hypothermia therapy after traumatic brain injury in children.

Hutchison JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ, Dirks PB, Doucette S, Fergusson D, Gottesman R, Joffe AR, Kirpalani HM, Meyer PG, Morris KP, Moher D, Singh RN, Skippen PW; Hypothermia Pediatric Head Injury Trial Investigators and the Canadian Critical Care Trials Group.

N Engl J Med. 2008 Jun 5;358(23):2447-56. doi: 10.1056/NEJMoa0706930.


Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial.

Kirkegaard H, Søreide E, de Haas I, Pettilä V, Taccone FS, Arus U, Storm C, Hassager C, Nielsen JF, Sørensen CA, Ilkjær S, Jeppesen AN, Grejs AM, Duez CHV, Hjort J, Larsen AI, Toome V, Tiainen M, Hästbacka J, Laitio T, Skrifvars MB.

JAMA. 2017 Jul 25;318(4):341-350. doi: 10.1001/jama.2017.8978.


Early induction of hypothermia for evacuated intracranial hematomas: a post hoc analysis of two clinical trials.

Clifton GL, Coffey CS, Fourwinds S, Zygun D, Valadka A, Smith KR Jr, Frisby ML, Bucholz RD, Wilde EA, Levin HS, Okonkwo DO.

J Neurosurg. 2012 Oct;117(4):714-20. doi: 10.3171/2012.6.JNS111690. Epub 2012 Jul 27.


Meta-Analysis of Therapeutic Hypothermia for Traumatic Brain Injury in Adult and Pediatric Patients.

Crompton EM, Lubomirova I, Cotlarciuc I, Han TS, Sharma SD, Sharma P.

Crit Care Med. 2017 Apr;45(4):575-583. doi: 10.1097/CCM.0000000000002205. Review.


Hypothermia for Traumatic Brain Injury in Children-A Phase II Randomized Controlled Trial.

Beca J, McSharry B, Erickson S, Yung M, Schibler A, Slater A, Wilkins B, Singhal A, Williams G, Sherring C, Butt W; Pediatric Study Group of the Australia and New Zealand Intensive Care Society Clinical Trials Group.

Crit Care Med. 2015 Jul;43(7):1458-66. doi: 10.1097/CCM.0000000000000947.


Induced hypothermia in severe bacterial meningitis: a randomized clinical trial.

Mourvillier B, Tubach F, van de Beek D, Garot D, Pichon N, Georges H, Lefevre LM, Bollaert PE, Boulain T, Luis D, Cariou A, Girardie P, Chelha R, Megarbane B, Delahaye A, Chalumeau-Lemoine L, Legriel S, Beuret P, Brivet F, Bruel C, Camou F, Chatellier D, Chillet P, Clair B, Constantin JM, Duguet A, Galliot R, Bayle F, Hyvernat H, Ouchenir K, Plantefeve G, Quenot JP, Richecoeur J, Schwebel C, Sirodot M, Esposito-Farèse M, Le Tulzo Y, Wolff M.

JAMA. 2013 Nov 27;310(20):2174-83. doi: 10.1001/jama.2013.280506.


Initiating Nutritional Support Before 72 Hours Is Associated With Favorable Outcome After Severe Traumatic Brain Injury in Children: A Secondary Analysis of a Randomized, Controlled Trial of Therapeutic Hypothermia.

Meinert E, Bell MJ, Buttram S, Kochanek PM, Balasubramani GK, Wisniewski SR, Adelson PD; Pediatric Traumatic Brain Injury Consortium: Hypothermia Investigators.

Pediatr Crit Care Med. 2018 Apr;19(4):345-352. doi: 10.1097/PCC.0000000000001471.


Applying cerebral hypothermia and brain oxygen monitoring in treating severe traumatic brain injury.

Lee HC, Chuang HC, Cho DY, Cheng KF, Lin PH, Chen CC.

World Neurosurg. 2010 Dec;74(6):654-60. doi: 10.1016/j.wneu.2010.06.019.


Prophylactic hypothermia for traumatic brain injury: a quantitative systematic review.

Fox JL, Vu EN, Doyle-Waters M, Brubacher JR, Abu-Laban R, Hu Z.

CJEM. 2010 Jul;12(4):355-64. Review.


Mortality Risk Stratification After Traumatic Brain Injury and Hazard of Death With Titrated Hypothermia in the Eurotherm3235Trial.

Andrews PJD, Rodriguez A, Suter P, Battison CG, Rhodes JKJ, Puddu I, Harris BA.

Crit Care Med. 2017 May;45(5):883-890. doi: 10.1097/CCM.0000000000002376.


Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial.

Adelson PD, Wisniewski SR, Beca J, Brown SD, Bell M, Muizelaar JP, Okada P, Beers SR, Balasubramani GK, Hirtz D; Paediatric Traumatic Brain Injury Consortium.

Lancet Neurol. 2013 Jun;12(6):546-53. doi: 10.1016/S1474-4422(13)70077-2. Epub 2013 May 8.


Prolonged mild therapeutic hypothermia versus fever control with tight hemodynamic monitoring and slow rewarming in patients with severe traumatic brain injury: a randomized controlled trial.

Maekawa T, Yamashita S, Nagao S, Hayashi N, Ohashi Y; Brain-Hypothermia Study Group.

J Neurotrauma. 2015 Apr 1;32(7):422-9. doi: 10.1089/neu.2013.3197. Epub 2015 Jan 8.


Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial.

Clifton GL, Valadka A, Zygun D, Coffey CS, Drever P, Fourwinds S, Janis LS, Wilde E, Taylor P, Harshman K, Conley A, Puccio A, Levin HS, McCauley SR, Bucholz RD, Smith KR, Schmidt JH, Scott JN, Yonas H, Okonkwo DO.

Lancet Neurol. 2011 Feb;10(2):131-9. doi: 10.1016/S1474-4422(10)70300-8. Epub 2010 Dec 17.


Protocol for a multicentre randomised controlled trial of early and sustained prophylactic hypothermia in the management of traumatic brain injury.

Nichol A, Gantner D, Presneill J, Murray L, Trapani T, Bernard S, Cameron P, Capellier G, Forbes A, McArthur C, Newby L, Rashford S, Rosenfeld JV, Smith T, Stephenson M, Varma D, Walker T, Webb S, Cooper DJ.

Crit Care Resusc. 2015 Jun;17(2):92-100.


Phase II clinical trial of moderate hypothermia after severe traumatic brain injury in children.

Adelson PD, Ragheb J, Kanev P, Brockmeyer D, Beers SR, Brown SD, Cassidy LD, Chang Y, Levin H.

Neurosurgery. 2005 Apr;56(4):740-54; discussion 740-54.


Therapeutic hypothermia decreases phenytoin elimination in children with traumatic brain injury.

Empey PE, Velez de Mendizabal N, Bell MJ, Bies RR, Anderson KB, Kochanek PM, Adelson PD, Poloyac SM; Pediatric TBI Consortium: Hypothermia Investigators.

Crit Care Med. 2013 Oct;41(10):2379-87. doi: 10.1097/CCM.0b013e318292316c.


Rationale, methodology, and implementation of a nationwide multicenter randomized controlled trial of long-term mild hypothermia for severe traumatic brain injury (the LTH-1 trial).

Lei J, Gao G, Mao Q, Feng J, Wang L, You W, Jiang J; LTH-1 trial collaborators.

Contemp Clin Trials. 2015 Jan;40:9-14. doi: 10.1016/j.cct.2014.11.008. Epub 2014 Nov 12.


Cooling for cerebral protection during brain surgery.

Galvin IM, Levy R, Boyd JG, Day AG, Wallace MC.

Cochrane Database Syst Rev. 2015 Jan 28;1:CD006638. doi: 10.1002/14651858.CD006638.pub3. Review.


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