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Items: 1 to 20 of 106

1.

Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression.

Kabacik S, Horvath S, Cohen H, Raj K.

Aging (Albany NY). 2018 Oct 17;10(10):2800-2815. doi: 10.18632/aging.101588.

2.

Epigenetic clock analyses of cellular senescence and ageing.

Lowe D, Horvath S, Raj K.

Oncotarget. 2016 Feb 23;7(8):8524-31. doi: 10.18632/oncotarget.7383.

3.

Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation.

MacKenzie KL, Franco S, May C, Sadelain M, Moore MA.

Exp Cell Res. 2000 Sep 15;259(2):336-50.

PMID:
10964501
4.

Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms.

Davis T, Singhrao SK, Wyllie FS, Haughton MF, Smith PJ, Wiltshire M, Wynford-Thomas D, Jones CJ, Faragher RG, Kipling D.

J Cell Sci. 2003 Apr 1;116(Pt 7):1349-57.

5.

Catalytically active human telomerase mutants with allele-specific biological properties.

Kim M, Xu L, Blackburn EH.

Exp Cell Res. 2003 Aug 15;288(2):277-87.

PMID:
12915119
6.

Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase.

Zhang D, Sun X, Liu J, Xie X, Cui W, Zhu Y.

Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):71-8. doi: 10.1161/ATVBAHA.114.303899. Epub 2014 Oct 30.

PMID:
25359865
7.

Expression of human telomerase reverse transcriptase mediates the senescence of mesenchymal stem cells through the PI3K/AKT signaling pathway.

Zhao Q, Wang XY, Yu XX, Zhai YX, He X, Wu S, Shi YA.

Int J Mol Med. 2015 Sep;36(3):857-64. doi: 10.3892/ijmm.2015.2284. Epub 2015 Jul 15.

PMID:
26178664
8.

MiRNA profile associated with replicative senescence, extended cell culture, and ectopic telomerase expression in human foreskin fibroblasts.

Bonifacio LN, Jarstfer MB.

PLoS One. 2010 Sep 1;5(9). pii: e12519. doi: 10.1371/journal.pone.0012519.

9.

An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype.

Stephens P, Cook H, Hilton J, Jones CJ, Haughton MF, Wyllie FS, Skinner JW, Harding KG, Kipling D, Thomas DW.

Exp Cell Res. 2003 Feb 1;283(1):22-35.

PMID:
12565817
10.

p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells.

Jones KR, Elmore LW, Jackson-Cook C, Demasters G, Povirk LF, Holt SE, Gewirtz DA.

Int J Radiat Biol. 2005 Jun;81(6):445-58.

PMID:
16308915
11.
12.

Stabilization of telomere length and karyotypic stability are directly correlated with the level of hTERT gene expression in primary fibroblasts.

Cui W, Aslam S, Fletcher J, Wylie D, Clinton M, Clark AJ.

J Biol Chem. 2002 Oct 11;277(41):38531-9. Epub 2002 Jul 16.

13.

Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence.

Patel PL, Suram A, Mirani N, Bischof O, Herbig U.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5024-33. doi: 10.1073/pnas.1602379113. Epub 2016 Aug 8.

15.

Ablation of human telomerase reverse transcriptase (hTERT) induces cellular senescence in gastric cancer through a galectin-3 dependent mechanism.

La SH, Kim SJ, Kang HG, Lee HW, Chun KH.

Oncotarget. 2016 Aug 30;7(35):57117-57130. doi: 10.18632/oncotarget.10986.

16.

[Extension of life-span of normal human fibroblasts by reconstitution of telomerase activity].

Wang Z, Yi J, Li H, Deng LF, Tang XM.

Shi Yan Sheng Wu Xue Bao. 2000 Jun;33(2):129-40. Chinese.

PMID:
12548976
17.

Endogenous oxidative stress prevents telomerase-dependent immortalization of human endothelial cells.

Voghel G, Thorin-Trescases N, Mamarbachi AM, Villeneuve L, Mallette FA, Ferbeyre G, Farhat N, Perrault LP, Carrier M, Thorin E.

Mech Ageing Dev. 2010 May;131(5):354-63. doi: 10.1016/j.mad.2010.04.004. Epub 2010 Apr 24. Erratum in: Mech Ageing Dev. 2010 Sep;131(9):599.

18.

Telomere loss, senescence, and genetic instability in CD4+ T lymphocytes overexpressing hTERT.

Röth A, Baerlocher GM, Schertzer M, Chavez E, Dührsen U, Lansdorp PM.

Blood. 2005 Jul 1;106(1):43-50. Epub 2005 Mar 1.

19.

Differential decrease in soluble and DNA-bound telomerase in senescent human fibroblasts.

Yehuda S, Yanai H, Priel E, Fraifeld VE.

Biogerontology. 2017 Aug;18(4):525-533. doi: 10.1007/s10522-017-9688-6. Epub 2017 Mar 1.

PMID:
28251405
20.

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