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Role of double knockdown of tPA and MMP-9 on regulating the left ventricular function and remodeling followed by transverse aortic constriction-induced hypertrophic cardiomyopathy in mice.

Sung PH, Chua S, Chen KH, Sun CK, Li YC, Huang CR, Luo CW, Chai HT, Lu HI, Yip HK.

Am J Transl Res. 2018 Sep 15;10(9):2781-2795. eCollection 2018.


SS31 therapy effectively protects the heart against transverse aortic constriction-induced hypertrophic cardiomyopathy damage.

Lu HI, Lee FY, Wallace CG, Sung PH, Chen KH, Sheu JJ, Chua S, Tong MS, Huang TH, Chen YL, Shao PL, Yip HK.

Am J Transl Res. 2017 Dec 15;9(12):5220-5237. eCollection 2017.


Entresto therapy effectively protects heart and lung against transverse aortic constriction induced cardiopulmonary syndrome injury in rat.

Lu HI, Tong MS, Chen KH, Lee FY, Chiang JY, Chung SY, Sung PH, Yip HK.

Am J Transl Res. 2018 Aug 15;10(8):2290-2305. eCollection 2018.


Exendin-4 therapy still offered an additional benefit on reducing transverse aortic constriction-induced cardiac hypertrophy-caused myocardial damage in DPP-4 deficient rats.

Lu HI, Chung SY, Chen YL, Huang TH, Zhen YY, Liu CF, Chang MW, Chen YL, Sheu JJ, Chua S, Yip HK, Lee FY.

Am J Transl Res. 2016 Feb 15;8(2):778-98. eCollection 2016.


The cardioprotective effect of melatonin and exendin-4 treatment in a rat model of cardiorenal syndrome.

Chua S, Lee FY, Chiang HJ, Chen KH, Lu HI, Chen YT, Yang CC, Lin KC, Chen YL, Kao GS, Chen CH, Chang HW, Yip HK.

J Pineal Res. 2016 Nov;61(4):438-456. doi: 10.1111/jpi.12357. Epub 2016 Sep 26.


Extracorporeal Shock Wave-Supported Adipose-Derived Fresh Stromal Vascular Fraction Preserved Left Ventricular (LV) Function and Inhibited LV Remodeling in Acute Myocardial Infarction in Rat.

Sung PH, Yin TC, Wallace CG, Chen KH, Shao PL, Lee FY, Sun CK, Sheu JJ, Chen YL, Omran MM, Chung SY, Wang CJ, Lee MS, Yip HK.

Oxid Med Cell Longev. 2018 Oct 17;2018:7518920. doi: 10.1155/2018/7518920. eCollection 2018.


Early Administration of Carvedilol Protected against Doxorubicin-Induced Cardiomyopathy.

Chen YL, Chung SY, Chai HT, Chen CH, Liu CF, Chen YL, Huang TH, Zhen YY, Sung PH, Sun CK, Chua S, Lu HI, Lee FY, Sheu JJ, Yip HK.

J Pharmacol Exp Ther. 2015 Dec;355(3):516-27. doi: 10.1124/jpet.115.225375. Epub 2015 Oct 28. Erratum in: J Pharmacol Exp Ther. 2017 Feb;360(2):312.


Extracorporeal shock wave treatment attenuated left ventricular dysfunction and remodeling in mini-pig with cardiorenal syndrome.

Sheu JJ, Ali HEE, Cheng BC, Chiang HJ, Sung PH, Chen KH, Yang CC, Chen YT, Chiang JY, Lin PY, Chua S, Chai HT, Chung SY, Sun CK, Yip HK.

Oncotarget. 2017 May 30;8(33):54747-54763. doi: 10.18632/oncotarget.18287. eCollection 2017 Aug 15.


Administration of antioxidant peptide SS-31 attenuates transverse aortic constriction-induced pulmonary arterial hypertension in mice.

Lu HI, Huang TH, Sung PH, Chen YL, Chua S, Chai HY, Chung SY, Liu CF, Sun CK, Chang HW, Zhen YY, Lee FY, Yip HK.

Acta Pharmacol Sin. 2016 May;37(5):589-603. doi: 10.1038/aps.2015.162. Epub 2016 Apr 11.


Early administration of empagliflozin preserved heart function in cardiorenal syndrome in rat.

Yang CC, Chen YT, Wallace CG, Chen KH, Cheng BC, Sung PH, Li YC, Ko SF, Chang HW, Yip HK.

Biomed Pharmacother. 2019 Jan;109:658-670. doi: 10.1016/j.biopha.2018.10.095. Epub 2018 Nov 4.


Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload.

Matsusaka H, Ide T, Matsushima S, Ikeuchi M, Kubota T, Sunagawa K, Kinugawa S, Tsutsui H.

Hypertension. 2006 Apr;47(4):711-7. Epub 2006 Feb 27.


BMP-7 attenuates left ventricular remodelling under pressure overload and facilitates reverse remodelling and functional recovery.

Merino D, Villar AV, García R, Tramullas M, Ruiz L, Ribas C, Cabezudo S, Nistal JF, Hurlé MA.

Cardiovasc Res. 2016 Jun 1;110(3):331-45. doi: 10.1093/cvr/cvw076. Epub 2016 Apr 11.


Effects of adiponectin deficiency on structural and metabolic remodeling in mice subjected to pressure overload.

O'Shea KM, Chess DJ, Khairallah RJ, Rastogi S, Hecker PA, Sabbah HN, Walsh K, Stanley WC.

Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1639-45. doi: 10.1152/ajpheart.00957.2009. Epub 2010 Mar 26.


Connective tissue growth factor inhibition attenuates left ventricular remodeling and dysfunction in pressure overload-induced heart failure.

Szabó Z, Magga J, Alakoski T, Ulvila J, Piuhola J, Vainio L, Kivirikko KI, Vuolteenaho O, Ruskoaho H, Lipson KE, Signore P, Kerkelä R.

Hypertension. 2014 Jun;63(6):1235-40. doi: 10.1161/HYPERTENSIONAHA.114.03279. Epub 2014 Mar 31.


Dapagliflozin Attenuates Cardiac Remodeling in Mice Model of Cardiac Pressure Overload.

Shi L, Zhu D, Wang S, Jiang A, Li F.

Am J Hypertens. 2019 Apr 22;32(5):452-459. doi: 10.1093/ajh/hpz016.


Combined Therapy with SS31 and Mitochondria Mitigates Myocardial Ischemia-Reperfusion Injury in Rats.

Lee FY, Shao PL, Wallace CG, Chua S, Sung PH, Ko SF, Chai HT, Chung SY, Chen KH, Lu HI, Chen YL, Huang TH, Sheu JJ, Yip HK.

Int J Mol Sci. 2018 Sep 15;19(9). pii: E2782. doi: 10.3390/ijms19092782.


Cardiac hypertrophy is enhanced in PPAR alpha-/- mice in response to chronic pressure overload.

Smeets PJ, Teunissen BE, Willemsen PH, van Nieuwenhoven FA, Brouns AE, Janssen BJ, Cleutjens JP, Staels B, van der Vusse GJ, van Bilsen M.

Cardiovasc Res. 2008 Apr 1;78(1):79-89. doi: 10.1093/cvr/cvn001. Epub 2008 Jan 10.


C-reactive protein overexpression exacerbates pressure overload-induced cardiac remodeling through enhanced inflammatory response.

Nagai T, Anzai T, Kaneko H, Mano Y, Anzai A, Maekawa Y, Takahashi T, Meguro T, Yoshikawa T, Fukuda K.

Hypertension. 2011 Feb;57(2):208-15. doi: 10.1161/HYPERTENSIONAHA.110.158915. Epub 2011 Jan 10.


Tissue plasminogen activator deficiency preserves neurological function and protects against murine acute ischemic stroke.

Yip HK, Yuen CM, Chen KH, Chai HT, Chung SY, Tong MS, Chen SY, Kao GS, Chen CH, Chen YL, Huang TH, Sun CK, Lee MS.

Int J Cardiol. 2016 Feb 15;205:133-141. doi: 10.1016/j.ijcard.2015.11.168. Epub 2015 Nov 23.


Effect of obesity reduction on preservation of heart function and attenuation of left ventricular remodeling, oxidative stress and inflammation in obese mice.

Wang HT, Liu CF, Tsai TH, Chen YL, Chang HW, Tsai CY, Leu S, Zhen YY, Chai HT, Chung SY, Chua S, Yen CH, Yip HK.

J Transl Med. 2012 Jul 11;10:145. doi: 10.1186/1479-5876-10-145.

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