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Items: 1 to 20 of 87


A Novel Actin Binding Drug with In Vivo Efficacy.

Ravichandran A, Geng M, Hull KG, Li J, Romo D, Lu SE, Albee A, Nutter C, Gordon DM, Ghannoum MA, Lockless SW, Smith L.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01585-18. doi: 10.1128/AAC.01585-18. Print 2019 Jan.


The antifungal occidiofungin triggers an apoptotic mechanism of cell death in yeast.

Emrick D, Ravichandran A, Gosai J, Lu S, Gordon DM, Smith L.

J Nat Prod. 2013 May 24;76(5):829-38. doi: 10.1021/np300678e. Epub 2013 May 14.


The Burkholderia contaminans MS14 ocfC gene encodes a xylosyltransferase for production of the antifungal occidiofungin.

Chen KC, Ravichandran A, Guerrero A, Deng P, Baird SM, Smith L, Lu SE.

Appl Environ Microbiol. 2013 May;79(9):2899-905. doi: 10.1128/AEM.00263-13. Epub 2013 Feb 22.


Genetic and biochemical map for the biosynthesis of occidiofungin, an antifungal produced by Burkholderia contaminans strain MS14.

Gu G, Smith L, Liu A, Lu SE.

Appl Environ Microbiol. 2011 Sep;77(17):6189-98. doi: 10.1128/AEM.00377-11. Epub 2011 Jul 8.


Occidiofungin, a unique antifungal glycopeptide produced by a strain of Burkholderia contaminans.

Lu SE, Novak J, Austin FW, Gu G, Ellis D, Kirk M, Wilson-Stanford S, Tonelli M, Smith L.

Biochemistry. 2009 Sep 8;48(35):8312-21. doi: 10.1021/bi900814c.


Cellular conditions that modulate the fungicidal activity of occidiofungin.

Robinson CA, Denison C, Burkenstock A, Nutter C, Gordon DM.

J Appl Microbiol. 2017 Aug;123(2):380-391. doi: 10.1111/jam.13496. Epub 2017 Jul 12.


Nonclinical toxicological evaluation of occidiofungin, a unique glycolipopeptide antifungal.

Tan W, Cooley J, Austin F, Lu SE, Pruett SB, Smith L.

Int J Toxicol. 2012 Jul-Aug;31(4):326-36. doi: 10.1177/1091581812445185. Epub 2012 Jun 11.


Occidiofungin is an important component responsible for the antifungal activity of Burkholderia pyrrocinia strain Lyc2.

Wang XQ, Liu AX, Guerrero A, Liu J, Yu XQ, Deng P, Ma L, Baird SM, Smith L, Li XD, Lu SE.

J Appl Microbiol. 2016 Mar;120(3):607-18. doi: 10.1111/jam.13036.


Comparative genome-wide analysis reveals that Burkholderia contaminans MS14 possesses multiple antimicrobial biosynthesis genes but not major genetic loci required for pathogenesis.

Deng P, Wang X, Baird SM, Showmaker KC, Smith L, Peterson DG, Lu S.

Microbiologyopen. 2016 Jun;5(3):353-69. doi: 10.1002/mbo3.333. Epub 2016 Jan 14.


Occidiofungin's chemical stability and in vitro potency against Candida species.

Ellis D, Gosai J, Emrick C, Heintz R, Romans L, Gordon D, Lu SE, Austin F, Smith L.

Antimicrob Agents Chemother. 2012 Feb;56(2):765-9. doi: 10.1128/AAC.05231-11. Epub 2011 Nov 21.


Burkholdines from Burkholderia ambifaria: antifungal agents and possible virulence factors.

Lin Z, Falkinham JO 3rd, Tawfik KA, Jeffs P, Bray B, Dubay G, Cox JE, Schmidt EW.

J Nat Prod. 2012 Sep 28;75(9):1518-23. Epub 2012 Sep 18.


Candida albicans AGE3, the ortholog of the S. cerevisiae ARF-GAP-encoding gene GCS1, is required for hyphal growth and drug resistance.

Lettner T, Zeidler U, Gimona M, Hauser M, Breitenbach M, Bito A.

PLoS One. 2010 Aug 5;5(8):e11993. doi: 10.1371/journal.pone.0011993.


Development of Anti-Virulence Approaches for Candidiasis via a Novel Series of Small-Molecule Inhibitors of Candida albicans Filamentation.

Romo JA, Pierce CG, Chaturvedi AK, Lazzell AL, McHardy SF, Saville SP, Lopez-Ribot JL.

MBio. 2017 Dec 5;8(6). pii: e01991-17. doi: 10.1128/mBio.01991-17.


The presence of two cyclase thioesterases expands the conformational freedom of the cyclic Peptide occidiofungin.

Ravichandran A, Gu G, Escano J, Lu SE, Smith L.

J Nat Prod. 2013 Feb 22;76(2):150-6. doi: 10.1021/np3005503. Epub 2013 Feb 8.


Srv2/CAP is required for polarized actin cable assembly and patch internalization during clathrin-mediated endocytosis.

Toshima JY, Horikomi C, Okada A, Hatori MN, Nagano M, Masuda A, Yamamoto W, Siekhaus DE, Toshima J.

J Cell Sci. 2016 Jan 15;129(2):367-79. doi: 10.1242/jcs.176651. Epub 2015 Nov 24.


The WASP homologue Las17 activates the novel actin-regulatory activity of Ysc84 to promote endocytosis in yeast.

Robertson AS, Allwood EG, Smith AP, Gardiner FC, Costa R, Winder SJ, Ayscough KR.

Mol Biol Cell. 2009 Mar;20(6):1618-28. doi: 10.1091/mbc.E08-09-0982. Epub 2009 Jan 21.


Reconstitution and protein composition analysis of endocytic actin patches.

Michelot A, Costanzo M, Sarkeshik A, Boone C, Yates JR 3rd, Drubin DG.

Curr Biol. 2010 Nov 9;20(21):1890-9. doi: 10.1016/j.cub.2010.10.016. Epub 2010 Oct 28.


The yeast actin cytoskeleton.

Mishra M, Huang J, Balasubramanian MK.

FEMS Microbiol Rev. 2014 Mar;38(2):213-27. doi: 10.1111/1574-6976.12064. Epub 2014 Feb 20. Review.


The F-actin capping protein is required for hyphal growth and full virulence but is dispensable for septum formation in Botrytis cinerea.

González-Rodríguez VE, Garrido C, Cantoral JM, Schumacher J.

Fungal Biol. 2016 Oct;120(10):1225-35. doi: 10.1016/j.funbio.2016.07.007. Epub 2016 Jul 22.


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