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Items: 1 to 20 of 98

1.

HDAC1 overexpression enhances β-cell proliferation by down-regulating Cdkn1b/p27.

Draney C, Austin MC, Leifer AH, Smith CJ, Kener KB, Aitken TJ, Hess KH, Haines AC, Lett LA, Hernandez-Carretero A, Fueger PT, Arlotto M, Tessem JS.

Biochem J. 2018 Dec 19;475(24):3997-4010. doi: 10.1042/BCJ20180465.

PMID:
30322885
2.

Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.

Schisler JC, Fueger PT, Babu DA, Hohmeier HE, Tessem JS, Lu D, Becker TC, Naziruddin B, Levy M, Mirmira RG, Newgard CB.

Mol Cell Biol. 2008 May;28(10):3465-76. doi: 10.1128/MCB.01791-07. Epub 2008 Mar 17.

3.

GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1).

Stein J, Milewski WM, Hara M, Steiner DF, Dey A.

Islets. 2011 Jan-Feb;3(1):21-34. Epub 2011 Jan 1.

4.

Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway.

Hobson A, Draney C, Stratford A, Becker TC, Lu D, Arlotto M, Tessem JS.

Islets. 2015;7(1):e1027854. doi: 10.1080/19382014.2015.1027854. Epub 2015 Jun 1.

5.

Exendin-4 stimulation of cyclin A2 in beta-cell proliferation.

Song WJ, Schreiber WE, Zhong E, Liu FF, Kornfeld BD, Wondisford FE, Hussain MA.

Diabetes. 2008 Sep;57(9):2371-81. doi: 10.2337/db07-1541. Epub 2008 Jun 10.

6.

Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children.

Lundh M, Christensen DP, Damgaard Nielsen M, Richardson SJ, Dahllöf MS, Skovgaard T, Berthelsen J, Dinarello CA, Stevenazzi A, Mascagni P, Grunnet LG, Morgan NG, Mandrup-Poulsen T.

Diabetologia. 2012 Sep;55(9):2421-31. doi: 10.1007/s00125-012-2615-0. Epub 2012 Jul 7.

PMID:
22772764
7.

SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation.

Iguchi H, Urashima Y, Inagaki Y, Ikeda Y, Okamura M, Tanaka T, Uchida A, Yamamoto TT, Kodama T, Sakai J.

J Biol Chem. 2007 Jun 29;282(26):19052-61. Epub 2007 Apr 4.

8.

HDAC1 inactivation induces mitotic defect and caspase-independent autophagic cell death in liver cancer.

Xie HJ, Noh JH, Kim JK, Jung KH, Eun JW, Bae HJ, Kim MG, Chang YG, Lee JY, Park H, Nam SW.

PLoS One. 2012;7(4):e34265. doi: 10.1371/journal.pone.0034265. Epub 2012 Apr 4.

9.

Cdk5r1 Overexpression Induces Primary β-Cell Proliferation.

Draney C, Hobson AE, Grover SG, Jack BO, Tessem JS.

J Diabetes Res. 2016;2016:6375804. doi: 10.1155/2016/6375804. Epub 2015 Dec 14.

10.

Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins.

Pang M, Ma L, Liu N, Ponnusamy M, Zhao TC, Yan H, Zhuang S.

J Cell Biochem. 2011 Aug;112(8):2138-48. doi: 10.1002/jcb.23135.

11.

Definition of a Skp2-c-Myc Pathway to Expand Human Beta-cells.

Tiwari S, Roel C, Tanwir M, Wills R, Perianayagam N, Wang P, Fiaschi-Taesch NM.

Sci Rep. 2016 Jul 6;6:28461. doi: 10.1038/srep28461.

12.
14.

HDAC1 and Klf4 interplay critically regulates human myeloid leukemia cell proliferation.

Huang Y, Chen J, Lu C, Han J, Wang G, Song C, Zhu S, Wang C, Li G, Kang J, Wang J.

Cell Death Dis. 2014 Oct 23;5:e1491. doi: 10.1038/cddis.2014.433.

15.

Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin.

Hayashi A, Horiuchi A, Kikuchi N, Hayashi T, Fuseya C, Suzuki A, Konishi I, Shiozawa T.

Int J Cancer. 2010 Sep 1;127(6):1332-46. doi: 10.1002/ijc.25151.

16.

Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.

Hayes HL, Moss LG, Schisler JC, Haldeman JM, Zhang Z, Rosenberg PB, Newgard CB, Hohmeier HE.

Mol Cell Biol. 2013 Oct;33(20):4017-29. doi: 10.1128/MCB.00469-13. Epub 2013 Aug 12.

17.

Nkx6.1-mediated insulin secretion and β-cell proliferation is dependent on upregulation of c-Fos.

Ray JD, Kener KB, Bitner BF, Wright BJ, Ballard MS, Barrett EJ, Hill JT, Moss LG, Tessem JS.

FEBS Lett. 2016 Jun;590(12):1791-803. doi: 10.1002/1873-3468.12208. Epub 2016 May 26.

18.

Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors.

Tessem JS, Moss LG, Chao LC, Arlotto M, Lu D, Jensen MV, Stephens SB, Tontonoz P, Hohmeier HE, Newgard CB.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5242-7. doi: 10.1073/pnas.1320953111. Epub 2014 Mar 24.

19.

Activation of PPARγ inhibits HDAC1-mediated pulmonary arterial smooth muscle cell proliferation and its potential mechanisms.

Li F, Zhu Y, Wan Y, Xie X, Ke R, Zhai C, Pan Y, Yan X, Wang J, Shi W, Li M.

Eur J Pharmacol. 2017 Nov 5;814:324-334. doi: 10.1016/j.ejphar.2017.08.045. Epub 2017 Sep 1.

PMID:
28867608
20.

The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.

Zupkovitz G, Grausenburger R, Brunmeir R, Senese S, Tischler J, Jurkin J, Rembold M, Meunier D, Egger G, Lagger S, Chiocca S, Propst F, Weitzer G, Seiser C.

Mol Cell Biol. 2010 Mar;30(5):1171-81. doi: 10.1128/MCB.01500-09. Epub 2009 Dec 22.

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