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Items: 1 to 20 of 104

1.

Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers.

Feng S, Cheng X, Zhang L, Lu X, Chaudhary S, Teng R, Frederickson C, Champion MM, Zhao R, Cheng L, Gong Y, Deng H, Lu X.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10094-10099. doi: 10.1073/pnas.1800695115. Epub 2018 Sep 19.

2.

Effective combinatorial immunotherapy for castration-resistant prostate cancer.

Lu X, Horner JW, Paul E, Shang X, Troncoso P, Deng P, Jiang S, Chang Q, Spring DJ, Sharma P, Zebala JA, Maeda DY, Wang YA, DePinho RA.

Nature. 2017 Mar 30;543(7647):728-732. doi: 10.1038/nature21676. Epub 2017 Mar 20. Erratum in: Nature. 2017 May 3;545(7652):116.

3.

The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.

Granum S, Sundvold-Gjerstad V, Gopalakrishnan RP, Berge T, Koll L, Abrahamsen G, Sørlie M, Spurkland A.

Sci Signal. 2014 Dec 9;7(355):ra118. doi: 10.1126/scisignal.2005384.

PMID:
25492967
4.

Tumor conditions induce bone marrow expansion of granulocytic, but not monocytic, immunosuppressive leukocytes with increased CXCR2 expression in mice.

Bian Z, Shi L, Venkataramani M, Abdelaal AM, Culpepper C, Kidder K, Liang H, Zen K, Liu Y.

Eur J Immunol. 2018 Mar;48(3):532-542. doi: 10.1002/eji.201746976. Epub 2017 Dec 8.

5.

Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells.

Merino E, Avila-Flores A, Shirai Y, Moraga I, Saito N, Mérida I.

J Immunol. 2008 May 1;180(9):5805-15.

6.

SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation.

Choi YB, Son M, Park M, Shin J, Yun Y.

J Biol Chem. 2010 Mar 5;285(10):7271-80. doi: 10.1074/jbc.M109.073726. Epub 2009 Dec 10.

7.

Conformational states of the kinase Lck regulate clustering in early T cell signaling.

Rossy J, Owen DM, Williamson DJ, Yang Z, Gaus K.

Nat Immunol. 2013 Jan;14(1):82-9. doi: 10.1038/ni.2488. Epub 2012 Dec 2.

PMID:
23202272
8.

Short-interfering RNA-mediated Lck knockdown results in augmented downstream T cell responses.

Methi T, Ngai J, Mahic M, Amarzguioui M, Vang T, Tasken K.

J Immunol. 2005 Dec 1;175(11):7398-406.

9.

Lck Inhibits Heat Shock Protein 65-Mediated Reverse Cholesterol Transport in T Cells.

Luo T, Hu J, Xi D, Xiong H, He W, Liu J, Li M, Lu H, Zhao J, Lai W, Guo Z.

J Immunol. 2016 Nov 15;197(10):3861-3870. Epub 2016 Oct 14.

11.

Inhibition of p56(lck) tyrosine kinase by isothiazolones.

Trevillyan JM, Chiou XG, Ballaron SJ, Tang QM, Buko A, Sheets MP, Smith ML, Putman CB, Wiedeman P, Tu N, Madar D, Smith HT, Gubbins EJ, Warrior UP, Chen YW, Mollison KW, Faltynek CR, Djurić SW.

Arch Biochem Biophys. 1999 Apr 1;364(1):19-29.

PMID:
10087161
12.

Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells.

Deng Y, Cheng J, Fu B, Liu W, Chen G, Zhang Q, Yang Y.

Oncogene. 2017 Feb 23;36(8):1090-1101. doi: 10.1038/onc.2016.273. Epub 2016 Sep 5.

PMID:
27593937
13.

The late endosomal transporter CD222 directs the spatial distribution and activity of Lck.

Pfisterer K, Forster F, Paster W, Supper V, Ohradanova-Repic A, Eckerstorfer P, Zwirzitz A, Donner C, Boulegue C, Schiller HB, Ondrovičová G, Acuto O, Stockinger H, Leksa V.

J Immunol. 2014 Sep 15;193(6):2718-32. doi: 10.4049/jimmunol.1303349. Epub 2014 Aug 15.

14.
15.

TCR-induced T cell activation leads to simultaneous phosphorylation at Y505 and Y394 of p56(lck) residues.

Nyakeriga AM, Garg H, Joshi A.

Cytometry A. 2012 Sep;81(9):797-805. doi: 10.1002/cyto.a.22070. Epub 2012 Jun 6.

16.

An essential role for the MAL protein in targeting Lck to the plasma membrane of human T lymphocytes.

Antón O, Batista A, Millán J, Andrés-Delgado L, Puertollano R, Correas I, Alonso MA.

J Exp Med. 2008 Dec 22;205(13):3201-13. doi: 10.1084/jem.20080552. Epub 2008 Dec 8.

17.
18.

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling.

Philipsen L, Reddycherla AV, Hartig R, Gumz J, Kästle M, Kritikos A, Poltorak MP, Prokazov Y, Turbin E, Weber A, Zuschratter W, Schraven B, Simeoni L, Müller AJ.

Sci Signal. 2017 Jan 17;10(462). pii: eaaf4736. doi: 10.1126/scisignal.aaf4736.

PMID:
28096507
19.

Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling.

Börner C, Smida M, Höllt V, Schraven B, Kraus J.

J Biol Chem. 2009 Dec 18;284(51):35450-60. doi: 10.1074/jbc.M109.006338.

20.

T cell-specific adapter protein inhibits T cell activation by modulating Lck activity.

Sundvold V, Torgersen KM, Post NH, Marti F, King PD, Røttingen JA, Spurkland A, Lea T.

J Immunol. 2000 Sep 15;165(6):2927-31.

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