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Items: 1 to 20 of 99

1.

Aging phenotype(s) in kidneys of diabetic mice are p66ShcA dependent.

Vashistha H, Marrero L, Reiss K, Cohen AJ, Malhotra A, Javed T, Bradley A, Abbruscato F, Giusti S, Jimenez A, Mehra S, Kaushal D, Giorgio M, Pelicci PG, Kakoki M, Singhal PC, Bunnell B, Meggs LG.

Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1833-F1842. doi: 10.1152/ajprenal.00608.2017. Epub 2018 Sep 12.

PMID:
30207172
2.

p66ShcA modulates oxidative stress and survival of endothelial progenitor cells in response to high glucose.

Di Stefano V, Cencioni C, Zaccagnini G, Magenta A, Capogrossi MC, Martelli F.

Cardiovasc Res. 2009 Jun 1;82(3):421-9. doi: 10.1093/cvr/cvp082. Epub 2009 Mar 4.

PMID:
19261622
3.

Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney.

Vashistha H, Singhal PC, Malhotra A, Husain M, Mathieson P, Saleem MA, Kuriakose C, Seshan S, Wilk A, Delvalle L, Peruzzi F, Giorgio M, Pelicci PG, Smithies O, Kim HS, Kakoki M, Reiss K, Meggs LG.

Am J Physiol Renal Physiol. 2012 Dec 15;303(12):F1629-40. doi: 10.1152/ajprenal.00246.2012. Epub 2012 Sep 26.

4.

Diabetic nephropathy: lessons from the mouse.

Vashistha H, Meggs L.

Ochsner J. 2013 Spring;13(1):140-6.

5.

Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis.

Malhotra A, Vashistha H, Yadav VS, Dube MG, Kalra SP, Abdellatif M, Meggs LG.

Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H380-8. doi: 10.1152/ajpheart.00225.2008. Epub 2008 Dec 5.

6.

Inhibition of wild-type p66ShcA in mesangial cells prevents glycooxidant-dependent FOXO3a regulation and promotes the survival phenotype.

Chintapalli J, Yang S, Opawumi D, Goyal SR, Shamsuddin N, Malhotra A, Reiss K, Meggs LG.

Am J Physiol Renal Physiol. 2007 Feb;292(2):F523-30. Epub 2006 Oct 31.

7.

Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress.

Menini S, Amadio L, Oddi G, Ricci C, Pesce C, Pugliese F, Giorgio M, Migliaccio E, Pelicci P, Iacobini C, Pugliese G.

Diabetes. 2006 Jun;55(6):1642-50. Erratum in: Diabetes. 2017 Oct 24;:.

8.

Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.

Camici GG, Schiavoni M, Francia P, Bachschmid M, Martin-Padura I, Hersberger M, Tanner FC, Pelicci P, Volpe M, Anversa P, Lüscher TF, Cosentino F.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5217-22. Epub 2007 Mar 14.

9.

Deficit of p66ShcA restores redox-sensitive stress response program in cisplatin-induced acute kidney injury.

Rattanavich R, Plagov A, Kumar D, Rai P, Lederman R, Salhan D, Vashistha H, Malhotra A, Meggs LG, Singhal PC.

Exp Mol Pathol. 2013 Jun;94(3):445-52. doi: 10.1016/j.yexmp.2013.03.001. Epub 2013 Mar 16.

10.

p66ShcA modulates tissue response to hindlimb ischemia.

Zaccagnini G, Martelli F, Fasanaro P, Magenta A, Gaetano C, Di Carlo A, Biglioli P, Giorgio M, Martin-Padura I, Pelicci PG, Capogrossi MC.

Circulation. 2004 Jun 15;109(23):2917-23. Epub 2004 Jun 1.

PMID:
15173034
11.
12.

Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis.

Husain M, Meggs LG, Vashistha H, Simoes S, Griffiths KO, Kumar D, Mikulak J, Mathieson PW, Saleem MA, Del Valle L, Pina-Oviedo S, Wang JY, Seshan SV, Malhotra A, Reiss K, Singhal PC.

J Biol Chem. 2009 Jun 12;284(24):16648-58. doi: 10.1074/jbc.M109.008482. Epub 2009 Apr 21.

13.

p66(ShcA) and oxidative stress modulate myogenic differentiation and skeletal muscle regeneration after hind limb ischemia.

Zaccagnini G, Martelli F, Magenta A, Cencioni C, Fasanaro P, Nicoletti C, Biglioli P, Pelicci PG, Capogrossi MC.

J Biol Chem. 2007 Oct 26;282(43):31453-9. Epub 2007 Aug 28.

14.

Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation.

Menini S, Iacobini C, Ricci C, Oddi G, Pesce C, Pugliese F, Block K, Abboud HE, Giorgio M, Migliaccio E, Pelicci PG, Pugliese G.

Diabetologia. 2007 Sep;50(9):1997-2007. doi: 10.1007/s00125-007-0728-7. Epub 2007 Jul 5.

PMID:
17611735
15.

Mesenchymal stem cells-derived MFG-E8 accelerates diabetic cutaneous wound healing.

Uchiyama A, Motegi SI, Sekiguchi A, Fujiwara C, Perera B, Ogino S, Yokoyama Y, Ishikawa O.

J Dermatol Sci. 2017 Jun;86(3):187-197. doi: 10.1016/j.jdermsci.2017.02.285. Epub 2017 Mar 6.

PMID:
28302404
16.

Role of the life span determinant P66(shcA) in ethanol-induced liver damage.

Koch OR, Fusco S, Ranieri SC, Maulucci G, Palozza P, Larocca LM, Cravero AA, Farre' SM, De Spirito M, Galeotti T, Pani G.

Lab Invest. 2008 Jul;88(7):750-60. doi: 10.1038/labinvest.2008.44. Epub 2008 May 19.

17.

The redox protein p66(shc) mediates cochlear vascular dysfunction and transient noise-induced hearing loss.

Fetoni AR, Eramo SL, Paciello F, Rolesi R, Samengo D, Paludetti G, Troiani D, Pani G.

Sci Rep. 2016 May 9;6:25450. doi: 10.1038/srep25450.

18.

Enhanced age-dependent cerebrovascular dysfunction is mediated by adaptor protein p66Shc.

Shi Y, Savarese G, Perrone-Filardi P, Lüscher TF, Camici GG.

Int J Cardiol. 2014 Aug 20;175(3):446-50. doi: 10.1016/j.ijcard.2014.06.025. Epub 2014 Jun 27.

PMID:
25012499
19.

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1-/- mice is correlated to increased cellular senescence.

Zhang Y, Unnikrishnan A, Deepa SS, Liu Y, Li Y, Ikeno Y, Sosnowska D, Van Remmen H, Richardson A.

Redox Biol. 2017 Apr;11:30-37. doi: 10.1016/j.redox.2016.10.014. Epub 2016 Nov 2.

20.

Genetic modification of human mesenchymal stem cells helps to reduce adiposity and improve glucose tolerance in an obese diabetic mouse model.

Sen S, Domingues CC, Rouphael C, Chou C, Kim C, Yadava N.

Stem Cell Res Ther. 2015 Dec 9;6:242. doi: 10.1186/s13287-015-0224-9.

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