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Items: 1 to 20 of 112


A Mutant p53-Dependent Embryonic Stem Cell Gene Signature Is Associated with Augmented Tumorigenesis of Stem Cells.

Koifman G, Shetzer Y, Eizenberger S, Solomon H, Rotkopf R, Molchadsky A, Lonetto G, Goldfinger N, Rotter V.

Cancer Res. 2018 Oct 15;78(20):5833-5847. doi: 10.1158/0008-5472.CAN-18-0805. Epub 2018 Aug 28.


Mutant p53 gain of function can be at the root of dedifferentiation of human osteosarcoma MG63 cells into 3AB-OS cancer stem cells.

Di Fiore R, Marcatti M, Drago-Ferrante R, D'Anneo A, Giuliano M, Carlisi D, De Blasio A, Querques F, Pastore L, Tesoriere G, Vento R.

Bone. 2014 Mar;60:198-212. doi: 10.1016/j.bone.2013.12.021. Epub 2013 Dec 27.


SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker.

Kolukula VK, Sahu G, Wellstein A, Rodriguez OC, Preet A, Iacobazzi V, D'Orazi G, Albanese C, Palmieri F, Avantaggiati ML.

Oncotarget. 2014 Mar 15;5(5):1212-25.


Inhibition of glucosylceramide synthase eliminates the oncogenic function of p53 R273H mutant in the epithelial-mesenchymal transition and induced pluripotency of colon cancer cells.

Hosain SB, Khiste SK, Uddin MB, Vorubindi V, Ingram C, Zhang S, Hill RA, Gu X, Liu YY.

Oncotarget. 2016 Sep 13;7(37):60575-60592. doi: 10.18632/oncotarget.11169.


Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.

Solomon H, Dinowitz N, Pateras IS, Cooks T, Shetzer Y, Molchadsky A, Charni M, Rabani S, Koifman G, Tarcic O, Porat Z, Kogan-Sakin I, Goldfinger N, Oren M, Harris CC, Gorgoulis VG, Rotter V.

Oncogene. 2018 Mar;37(12):1669-1684. doi: 10.1038/s41388-017-0060-8. Epub 2018 Jan 18.


LGR5 Is a Gastric Cancer Stem Cell Marker Associated with Stemness and the EMT Signature Genes NANOG, NANOGP8, PRRX1, TWIST1, and BMI1.

Wang B, Chen Q, Cao Y, Ma X, Yin C, Jia Y, Zang A, Fan W.

PLoS One. 2016 Dec 29;11(12):e0168904. doi: 10.1371/journal.pone.0168904. eCollection 2016.


Lunatic Fringe and p53 Cooperatively Suppress Mesenchymal Stem-Like Breast Cancer.

Chung WC, Zhang S, Challagundla L, Zhou Y, Xu K.

Neoplasia. 2017 Nov;19(11):885-895. doi: 10.1016/j.neo.2017.08.006. Epub 2017 Sep 19.


Long Non-Coding RNA HOTAIR Regulates the Proliferation, Self-Renewal Capacity, Tumor Formation and Migration of the Cancer Stem-Like Cell (CSC) Subpopulation Enriched from Breast Cancer Cells.

Deng J, Yang M, Jiang R, An N, Wang X, Liu B.

PLoS One. 2017 Jan 25;12(1):e0170860. doi: 10.1371/journal.pone.0170860. eCollection 2017.


Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cells by targeting the transcription factors FOXO3a and FOXM1.

Tanaka N, Zhao M, Tang L, Patel AA, Xi Q, Van HT, Takahashi H, Osman AA, Zhang J, Wang J, Myers JN, Zhou G.

Oncogene. 2018 Mar;37(10):1279-1292. doi: 10.1038/s41388-017-0032-z. Epub 2017 Dec 22.


Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation.

Rivlin N, Katz S, Doody M, Sheffer M, Horesh S, Molchadsky A, Koifman G, Shetzer Y, Goldfinger N, Rotter V, Geiger T.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):7006-11. doi: 10.1073/pnas.1320428111. Epub 2014 Apr 28.


Oncogenic Mutant p53 Gain of Function Nourishes the Vicious Cycle of Tumor Development and Cancer Stem-Cell Formation.

Shetzer Y, Molchadsky A, Rotter V.

Cold Spring Harb Perspect Med. 2016 Oct 3;6(10). pii: a026203. doi: 10.1101/cshperspect.a026203. Review.


Mutations in bone marrow-derived stromal stem cells unmask latent malignancy.

Houghton J, Li H, Fan X, Liu Y, Liu JH, Rao VP, Poutahidis T, Taylor CL, Jackson EA, Hewes C, Lyle S, Cerny A, Bowen G, Cerny J, Moore N, Kurt-Jones EA, Erdman SE.

Stem Cells Dev. 2010 Aug;19(8):1153-66. doi: 10.1089/scd.2009.0439.


Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice.

Song CQ, Li Y, Mou H, Moore J, Park A, Pomyen Y, Hough S, Kennedy Z, Fischer A, Yin H, Anderson DG, Conte D Jr, Zender L, Wang XW, Thorgeirsson S, Weng Z, Xue W.

Gastroenterology. 2017 Apr;152(5):1161-1173.e1. doi: 10.1053/j.gastro.2016.12.002. Epub 2016 Dec 10.


S100B Mediates Stemness of Ovarian Cancer Stem-Like Cells Through Inhibiting p53.

Yang T, Cheng J, Yang Y, Qi W, Zhao Y, Long H, Xie R, Zhu B.

Stem Cells. 2017 Feb;35(2):325-336. doi: 10.1002/stem.2472. Epub 2016 Aug 21.


Overlapping genes may control reprogramming of mouse somatic cells into induced pluripotent stem cells (iPSCs) and breast cancer stem cells.

Mosca E, Cocola C, Sabour D, Pelucchi P, Bertalot G, Palumbo O, Carella M, Götte M, Schöler HR, Reinbold R, Zucchi I, Milanesi L.

In Silico Biol. 2010;10(5-6):207-21. doi: 10.3233/ISB-2010-0437.


Downregulation of DNMT3A by miR-708-5p Inhibits Lung Cancer Stem Cell-like Phenotypes through Repressing Wnt/β-catenin Signaling.

Liu T, Wu X, Chen T, Luo Z, Hu X.

Clin Cancer Res. 2018 Apr 1;24(7):1748-1760. doi: 10.1158/1078-0432.CCR-17-1169. Epub 2017 Sep 28.


ICAM1 Is a Potential Cancer Stem Cell Marker of Esophageal Squamous Cell Carcinoma.

Tsai ST, Wang PJ, Liou NJ, Lin PS, Chen CH, Chang WC.

PLoS One. 2015 Nov 16;10(11):e0142834. doi: 10.1371/journal.pone.0142834. eCollection 2015.


EGFR inhibition abrogates leiomyosarcoma cell chemoresistance through inactivation of survival pathways and impairment of CSC potential.

Sette G, Salvati V, Memeo L, Fecchi K, Colarossi C, Di Matteo P, Signore M, Biffoni M, D'Andrea V, De Antoni E, Canzonieri V, De Maria R, Eramo A.

PLoS One. 2012;7(10):e46891. doi: 10.1371/journal.pone.0046891. Epub 2012 Oct 8.


p53 regulates the proliferation, differentiation and spontaneous transformation of mesenchymal stem cells.

Armesilla-Diaz A, Elvira G, Silva A.

Exp Cell Res. 2009 Dec 10;315(20):3598-610. doi: 10.1016/j.yexcr.2009.08.004. Epub 2009 Aug 15.


EZH2 Palmitoylation Mediated by ZDHHC5 in p53-Mutant Glioma Drives Malignant Development and Progression.

Chen X, Ma H, Wang Z, Zhang S, Yang H, Fang Z.

Cancer Res. 2017 Sep 15;77(18):4998-5010. doi: 10.1158/0008-5472.CAN-17-1139. Epub 2017 Aug 3.

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