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Identification of an Essential Cytoplasmic Region of Interleukin-7 Receptor α Subunit in B-Cell Development.

Kasai H, Kuwabara T, Matsui Y, Nakajima K, Kondo M.

Int J Mol Sci. 2018 Aug 25;19(9). pii: E2522. doi: 10.3390/ijms19092522.


The survival and differentiation of pro-B and pre-B cells in the bone marrow is dependent on IL-7Rα Tyr449.

Patton DT, Plumb AW, Abraham N.

J Immunol. 2014 Oct 1;193(7):3446-55. doi: 10.4049/jimmunol.1302925. Epub 2014 Aug 20.


An Enhancer of the IL-7 Receptor α-Chain Locus Controls IL-7 Receptor Expression and Maintenance of Peripheral T Cells.

Abe A, Tani-ichi S, Shitara S, Cui G, Yamada H, Miyachi H, Kitano S, Hara T, Abe R, Yoshikai Y, Ikuta K.

J Immunol. 2015 Oct 1;195(7):3129-38. doi: 10.4049/jimmunol.1302447. Epub 2015 Sep 2.


The development and survival but not function of follicular B cells is dependent on IL-7Rα Tyr449 signaling.

Patton DT, Plumb AW, Redpath SA, Osborne LC, Perona-Wright G, Abraham N.

PLoS One. 2014 Feb 13;9(2):e88771. doi: 10.1371/journal.pone.0088771. eCollection 2014. Erratum in: PLoS One. 2014;9(3):e93316.


TSLP or IL-7 provide an IL-7Rα signal that is critical for human B lymphopoiesis.

Milford TA, Su RJ, Francis OL, Baez I, Martinez SR, Coats JS, Weldon AJ, Calderon MN, Nwosu MC, Botimer AR, Suterwala BT, Zhang XB, Morris CL, Weldon DJ, Dovat S, Payne KJ.

Eur J Immunol. 2016 Sep;46(9):2155-61. doi: 10.1002/eji.201646307. Epub 2016 Jul 12.


Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients.

Rose T, Lambotte O, Pallier C, Delfraissy JF, Colle JH.

J Immunol. 2009 Jun 15;182(12):7389-97. doi: 10.4049/jimmunol.0900190.


Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.

Malin S, McManus S, Cobaleda C, Novatchkova M, Delogu A, Bouillet P, Strasser A, Busslinger M.

Nat Immunol. 2010 Feb;11(2):171-9. doi: 10.1038/ni.1827. Epub 2009 Nov 29.


Interleukin-7 Induces Osteoclast Formation via STAT5, Independent of Receptor Activator of NF-kappaB Ligand.

Kim JH, Sim JH, Lee S, Seol MA, Ye SK, Shin HM, Lee EB, Lee YJ, Choi YJ, Yoo WH, Kim JH, Kim WU, Lee DS, Kim JH, Kang I, Kang SW, Kim HR.

Front Immunol. 2017 Oct 20;8:1376. doi: 10.3389/fimmu.2017.01376. eCollection 2017. Erratum in: Front Immunol. 2017 Dec 07;8:1735.


Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction.

Isaksen DE, Baumann H, Trobridge PA, Farr AG, Levin SD, Ziegler SF.

J Immunol. 1999 Dec 1;163(11):5971-7.


Screening for peptides targeted to IL-7Rα for molecular imaging of rheumatoid arthritis synovium.

Burtea C, Laurent S, Sanli T, Fanfone D, Devalckeneer A, Sauvage S, Beckers MC, Rorive S, Salmon I, Vander Elst L, Lauwerys BR, Muller RN.

Arthritis Res Ther. 2016 Oct 12;18(1):230.


Thymic stromal-derived lymphopoietin induces proliferation of pre-B leukemia and antagonizes mTOR inhibitors, suggesting a role for interleukin-7Ralpha signaling.

Brown VI, Hulitt J, Fish J, Sheen C, Bruno M, Xu Q, Carroll M, Fang J, Teachey D, Grupp SA.

Cancer Res. 2007 Oct 15;67(20):9963-70.


Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators.

Hartgring SA, Willis CR, Alcorn D, Nelson LJ, Bijlsma JW, Lafeber FP, van Roon JA.

Arthritis Rheum. 2010 Sep;62(9):2716-25. doi: 10.1002/art.27578.


Direct interaction between Kit and the interleukin-7 receptor.

Jahn T, Sindhu S, Gooch S, Seipel P, Lavori P, Leifheit E, Weinberg K.

Blood. 2007 Sep 15;110(6):1840-7. Epub 2007 Jun 6.

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