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The N-recognin UBR4 of the N-end rule pathway is targeted to and required for the biogenesis of the early endosome.

Kim ST, Lee YJ, Tasaki T, Mun SR, Hwang J, Kang MJ, Ganipisetti S, Yi EC, Kim BY, Kwon YT.

J Cell Sci. 2018 Sep 10;131(17). pii: jcs217646. doi: 10.1242/jcs.217646.


The N-recognin UBR4 of the N-end rule pathway is required for neurogenesis and homeostasis of cell surface proteins.

Kim ST, Lee YJ, Tasaki T, Hwang J, Kang MJ, Yi EC, Kim BY, Kwon YT.

PLoS One. 2018 Aug 29;13(8):e0202260. doi: 10.1371/journal.pone.0202260. eCollection 2018.


UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy.

Tasaki T, Kim ST, Zakrzewska A, Lee BE, Kang MJ, Yoo YD, Cha-Molstad HJ, Hwang J, Soung NK, Sung KS, Kim SH, Nguyen MD, Sun M, Yi EC, Kim BY, Kwon YT.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3800-5. doi: 10.1073/pnas.1217358110. Epub 2013 Feb 19.


The N-end rule proteolytic system in autophagy.

Kim ST, Tasaki T, Zakrzewska A, Yoo YD, Sa Sung K, Kim SH, Cha-Molstad H, Hwang J, Kim KA, Kim BY, Kwon YT.

Autophagy. 2013 Jul;9(7):1100-3. doi: 10.4161/auto.24643. Epub 2013 Apr 15.


A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.

Tasaki T, Mulder LC, Iwamatsu A, Lee MJ, Davydov IV, Varshavsky A, Muesing M, Kwon YT.

Mol Cell Biol. 2005 Aug;25(16):7120-36.


N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis.

Yoo YD, Mun SR, Ji CH, Sung KW, Kang KY, Heo AJ, Lee SH, An JY, Hwang J, Xie XQ, Ciechanover A, Kim BY, Kwon YT.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2716-E2724. doi: 10.1073/pnas.1719110115. Epub 2018 Mar 5.


KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.

Hong JH, Kaustov L, Coyaud E, Srikumar T, Wan J, Arrowsmith C, Raught B.

Mol Cell Proteomics. 2015 Mar;14(3):674-85. doi: 10.1074/mcp.M114.042168. Epub 2015 Jan 12.


The substrate recognition domains of the N-end rule pathway.

Tasaki T, Zakrzewska A, Dudgeon DD, Jiang Y, Lazo JS, Kwon YT.

J Biol Chem. 2009 Jan 16;284(3):1884-95. doi: 10.1074/jbc.M803641200. Epub 2008 Nov 13.


Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway.

Lee MJ, Pal K, Tasaki T, Roy S, Jiang Y, An JY, Banerjee R, Kwon YT.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):100-5. Epub 2007 Dec 27.


p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis.

Cha-Molstad H, Yu JE, Feng Z, Lee SH, Kim JG, Yang P, Han B, Sung KW, Yoo YD, Hwang J, McGuire T, Shim SM, Song HD, Ganipisetti S, Wang N, Jang JM, Lee MJ, Kim SJ, Lee KH, Hong JT, Ciechanover A, Mook-Jung I, Kim KP, Xie XQ, Kwon YT, Kim BY.

Nat Commun. 2017 Jul 24;8(1):102. doi: 10.1038/s41467-017-00085-7.


Regulation of autophagic proteolysis by the N-recognin SQSTM1/p62 of the N-end rule pathway.

Cha-Molstad H, Lee SH, Kim JG, Sung KW, Hwang J, Shim SM, Ganipisetti S, McGuire T, Mook-Jung I, Ciechanover A, Xie XQ, Kim BY, Kwon YT.

Autophagy. 2018;14(2):359-361. doi: 10.1080/15548627.2017.1415190. Epub 2018 Jan 29.


The N-end rule pathway.

Tasaki T, Sriram SM, Park KS, Kwon YT.

Annu Rev Biochem. 2012;81:261-89. doi: 10.1146/annurev-biochem-051710-093308. Epub 2012 Apr 10. Review.


Modulation of SQSTM1/p62 activity by N-terminal arginylation of the endoplasmic reticulum chaperone HSPA5/GRP78/BiP.

Cha-Molstad H, Yu JE, Lee SH, Kim JG, Sung KS, Hwang J, Yoo YD, Lee YJ, Kim ST, Lee DH, Ciechanover A, Kim BY, Kwon YT.

Autophagy. 2016;12(2):426-8. doi: 10.1080/15548627.2015.1126047.


The N-end rule and retroviral infection: no effect on integrase.

Boso G, Tasaki T, Kwon YT, Somia NV.

Virol J. 2013 Jul 13;10:233. doi: 10.1186/1743-422X-10-233.


Non-26S proteasome proteolytic role of ubiquitin in plant endocytosis and endosomal trafficking(F).

Tian M, Xie Q.

J Integr Plant Biol. 2013 Jan;55(1):54-63. doi: 10.1111/jipb.12007. Review.


Crosstalk and Interplay between the Ubiquitin-Proteasome System and Autophagy.

Ji CH, Kwon YT.

Mol Cells. 2017 Jul 31;40(7):441-449. doi: 10.14348/molcells.2017.0115. Epub 2017 Jul 24. Review.


Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling.

Morrison J, Laurent-Rolle M, Maestre AM, Rajsbaum R, Pisanelli G, Simon V, Mulder LC, Fernandez-Sesma A, García-Sastre A.

PLoS Pathog. 2013 Mar;9(3):e1003265. doi: 10.1371/journal.ppat.1003265. Epub 2013 Mar 28.


Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems.

Tasaki T, Sohr R, Xia Z, Hellweg R, Hörtnagl H, Varshavsky A, Kwon YT.

J Biol Chem. 2007 Jun 22;282(25):18510-20. Epub 2007 Apr 26.


The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.

Ashton-Beaucage D, Lemieux C, Udell CM, Sahmi M, Rochette S, Therrien M.

PLoS Biol. 2016 Aug 23;14(8):e1002539. doi: 10.1371/journal.pbio.1002539. eCollection 2016 Aug.


Atg5 regulates late endosome and lysosome biogenesis.

Peng J, Zhang R, Cui Y, Liu H, Zhao X, Huang L, Hu M, Yuan X, Ma B, Ma X, Takashi U, Masaaki K, Liang X, Yu L.

Sci China Life Sci. 2014 Jan;57(1):59-68. doi: 10.1007/s11427-013-4588-8. Epub 2013 Dec 23.


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