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Items: 1 to 20 of 93


Comparative genomics and evolution of trans-activating RNAs in Class 2 CRISPR-Cas systems.

Faure G, Shmakov SA, Makarova KS, Wolf YI, Crawley AB, Barrangou R, Koonin EV.

RNA Biol. 2019 Apr;16(4):435-448. doi: 10.1080/15476286.2018.1493331. Epub 2018 Aug 14.


The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems.

Chylinski K, Le Rhun A, Charpentier E.

RNA Biol. 2013 May;10(5):726-37. doi: 10.4161/rna.24321. Epub 2013 Apr 5.


The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA.

Fonfara I, Richter H, Bratovič M, Le Rhun A, Charpentier E.

Nature. 2016 Apr 28;532(7600):517-21. doi: 10.1038/nature17945. Epub 2016 Apr 20.


Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity.

Charpentier E, Richter H, van der Oost J, White MF.

FEMS Microbiol Rev. 2015 May;39(3):428-41. doi: 10.1093/femsre/fuv023. Epub 2015 May 19. Review.


Prediction and diversity of tracrRNAs from type II CRISPR-Cas systems.

Chyou TY, Brown CM.

RNA Biol. 2019 Apr;16(4):423-434. doi: 10.1080/15476286.2018.1498281. Epub 2018 Aug 2.


crRNA and tracrRNA guide Cas9-mediated DNA interference in Streptococcus thermophilus.

Karvelis T, Gasiunas G, Miksys A, Barrangou R, Horvath P, Siksnys V.

RNA Biol. 2013 May;10(5):841-51. doi: 10.4161/rna.24203. Epub 2013 Mar 27.


Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems.

Shmakov S, Abudayyeh OO, Makarova KS, Wolf YI, Gootenberg JS, Semenova E, Minakhin L, Joung J, Konermann S, Severinov K, Zhang F, Koonin EV.

Mol Cell. 2015 Nov 5;60(3):385-97. doi: 10.1016/j.molcel.2015.10.008. Epub 2015 Oct 22.


In silico Analysis Suggests Common Appearance of scaRNAs in Type II Systems and Their Association With Bacterial Virulence.

Guzina J, Chen WH, Stankovic T, Djordjevic M, Zdobnov E, Djordjevic M.

Front Genet. 2018 Oct 17;9:474. doi: 10.3389/fgene.2018.00474. eCollection 2018.


Prediction and Validation of Native and Engineered Cas9 Guide Sequences.

Briner AE, Henriksen ED, Barrangou R.

Cold Spring Harb Protoc. 2016 Jul 1;2016(7). doi: 10.1101/pdb.prot086785.


Substrate generation for endonucleases of CRISPR/cas systems.

Zoephel J, Dwarakanath S, Richter H, Plagens A, Randau L.

J Vis Exp. 2012 Sep 8;(67). pii: 4277. doi: 10.3791/4277.


Guide RNAs: A Glimpse at the Sequences that Drive CRISPR-Cas Systems.

Briner AE, Barrangou R.

Cold Spring Harb Protoc. 2016 Jul 1;2016(7). doi: 10.1101/pdb.top090902.


Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis.

Zhang Y, Heidrich N, Ampattu BJ, Gunderson CW, Seifert HS, Schoen C, Vogel J, Sontheimer EJ.

Mol Cell. 2013 May 23;50(4):488-503. doi: 10.1016/j.molcel.2013.05.001.


A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.

Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E.

Science. 2012 Aug 17;337(6096):816-21. doi: 10.1126/science.1225829. Epub 2012 Jun 28.


Target RNA capture and cleavage by the Cmr type III-B CRISPR-Cas effector complex.

Hale CR, Cocozaki A, Li H, Terns RM, Terns MP.

Genes Dev. 2014 Nov 1;28(21):2432-43. doi: 10.1101/gad.250712.114.


Versatility of chemically synthesized guide RNAs for CRISPR-Cas9 genome editing.

Kelley ML, Strezoska Ž, He K, Vermeulen A, Smith Av.

J Biotechnol. 2016 Sep 10;233:74-83. doi: 10.1016/j.jbiotec.2016.06.011. Epub 2016 Jun 30. Review.


Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems.

Makarova KS, Aravind L, Wolf YI, Koonin EV.

Biol Direct. 2011 Jul 14;6:38. doi: 10.1186/1745-6150-6-38.


Efficient Multiple Genome Modifications Induced by the crRNAs, tracrRNA and Cas9 Protein Complex in Zebrafish.

Kotani H, Taimatsu K, Ohga R, Ota S, Kawahara A.

PLoS One. 2015 May 26;10(5):e0128319. doi: 10.1371/journal.pone.0128319. eCollection 2015.


Chimeric Guides Probe and Enhance Cas9 Biochemical Activity.

Kartje ZJ, Barkau CL, Rohilla KJ, Ageely EA, Gagnon KT.

Biochemistry. 2018 May 29;57(21):3027-3031. doi: 10.1021/acs.biochem.8b00107. Epub 2018 May 14.


Essential requirements for the detection and degradation of invaders by the Haloferax volcanii CRISPR/Cas system I-B.

Maier LK, Lange SJ, Stoll B, Haas KA, Fischer S, Fischer E, Duchardt-Ferner E, Wöhnert J, Backofen R, Marchfelder A.

RNA Biol. 2013 May;10(5):865-74. doi: 10.4161/rna.24282. Epub 2013 Apr 17.

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