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Items: 1 to 20 of 108

1.

Comparative phenotypic analysis of CHO clones and culture media for lactate shift.

Hong JK, Nargund S, Lakshmanan M, Kyriakopoulos S, Kim DY, Ang KS, Leong D, Yang Y, Lee DY.

J Biotechnol. 2018 Oct 10;283:97-104. doi: 10.1016/j.jbiotec.2018.07.042. Epub 2018 Aug 1.

PMID:
30076878
2.

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism.

Ma N, Ellet J, Okediadi C, Hermes P, McCormick E, Casnocha S.

Biotechnol Prog. 2009 Sep-Oct;25(5):1353-63. doi: 10.1002/btpr.238.

PMID:
19637321
3.

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process.

Luo J, Vijayasankaran N, Autsen J, Santuray R, Hudson T, Amanullah A, Li F.

Biotechnol Bioeng. 2012 Jan;109(1):146-56. doi: 10.1002/bit.23291. Epub 2011 Oct 16.

PMID:
21964570
4.

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity.

Zagari F, Jordan M, Stettler M, Broly H, Wurm FM.

N Biotechnol. 2013 Jan 25;30(2):238-45. doi: 10.1016/j.nbt.2012.05.021. Epub 2012 Jun 6.

PMID:
22683938
5.

Metabolic analysis of antibody producing CHO cells in fed-batch production.

Dean J, Reddy P.

Biotechnol Bioeng. 2013 Jun;110(6):1735-47. doi: 10.1002/bit.24826. Epub 2013 Feb 15.

PMID:
23296898
6.
7.

Reduction of ammonia and lactate through the coupling of glutamine synthetase selection and downregulation of lactate dehydrogenase-A in CHO cells.

Noh SM, Park JH, Lim MS, Kim JW, Lee GM.

Appl Microbiol Biotechnol. 2017 Feb;101(3):1035-1045. doi: 10.1007/s00253-016-7876-y. Epub 2016 Oct 4.

PMID:
27704181
8.

Effects of copper on CHO cells: cellular requirements and product quality considerations.

Yuk IH, Russell S, Tang Y, Hsu WT, Mauger JB, Aulakh RP, Luo J, Gawlitzek M, Joly JC.

Biotechnol Prog. 2015 Jan-Feb;31(1):226-38. doi: 10.1002/btpr.2004. Epub 2014 Oct 24.

PMID:
25311542
9.

Considerations on the lactate consumption by CHO cells in the presence of galactose.

Altamirano C, Illanes A, Becerra S, Cairó JJ, Gòdia F.

J Biotechnol. 2006 Oct 1;125(4):547-56. Epub 2006 Jul 5.

PMID:
16822573
10.

Benchmarking of commercially available CHO cell culture media for antibody production.

Reinhart D, Damjanovic L, Kaisermayer C, Kunert R.

Appl Microbiol Biotechnol. 2015 Jun;99(11):4645-57. doi: 10.1007/s00253-015-6514-4. Epub 2015 Apr 7.

11.

Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases.

Zhou M, Crawford Y, Ng D, Tung J, Pynn AF, Meier A, Yuk IH, Vijayasankaran N, Leach K, Joly J, Snedecor B, Shen A.

J Biotechnol. 2011 Apr 20;153(1-2):27-34. doi: 10.1016/j.jbiotec.2011.03.003. Epub 2011 Mar 30.

PMID:
21392546
12.

Effects of glutamine and asparagine on recombinant antibody production using CHO-GS cell lines.

Xu P, Dai XP, Graf E, Martel R, Russell R.

Biotechnol Prog. 2014 Nov-Dec;30(6):1457-68. doi: 10.1002/btpr.1957. Epub 2014 Aug 8.

PMID:
25079388
13.

Feeding lactate for CHO cell culture processes: impact on culture metabolism and performance.

Li J, Wong CL, Vijayasankaran N, Hudson T, Amanullah A.

Biotechnol Bioeng. 2012 May;109(5):1173-86. doi: 10.1002/bit.24389. Epub 2011 Dec 28.

PMID:
22124879
14.

Metabolic engineering of CHO cells for the development of a robust protein production platform.

Gupta SK, Srivastava SK, Sharma A, Nalage VHH, Salvi D, Kushwaha H, Chitnis NB, Shukla P.

PLoS One. 2017 Aug 1;12(8):e0181455. doi: 10.1371/journal.pone.0181455. eCollection 2017.

15.

Feed development for fed-batch CHO production process by semisteady state analysis.

Khattak SF, Xing Z, Kenty B, Koyrakh I, Li ZJ.

Biotechnol Prog. 2010 May-Jun;26(3):797-804. doi: 10.1002/btpr.362.

PMID:
20014108
16.

Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells.

Rajendra Y, Kiseljak D, Baldi L, Hacker DL, Wurm FM.

Biotechnol Lett. 2012 Apr;34(4):619-26. doi: 10.1007/s10529-011-0809-z. Epub 2011 Nov 30.

PMID:
22127760
17.

Fed-batch CHO cell t-PA production and feed glutamine replacement to reduce ammonia production.

Kim DY, Chaudhry MA, Kennard ML, Jardon MA, Braasch K, Dionne B, Butler M, Piret JM.

Biotechnol Prog. 2013 Jan-Feb;29(1):165-75. doi: 10.1002/btpr.1658. Epub 2012 Dec 4.

PMID:
23125190
18.

Metabolic engineering of CHO cells to alter lactate metabolism during fed-batch cultures.

Toussaint C, Henry O, Durocher Y.

J Biotechnol. 2016 Jan 10;217:122-31. doi: 10.1016/j.jbiotec.2015.11.010. Epub 2015 Nov 18.

19.

Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopy.

Goudar C, Biener R, Boisart C, Heidemann R, Piret J, de Graaf A, Konstantinov K.

Metab Eng. 2010 Mar;12(2):138-49. doi: 10.1016/j.ymben.2009.10.007. Epub 2009 Nov 5.

PMID:
19896555
20.

Effects of Peptone Supplementation in Different Culture Media on Growth, Metabolic Pathway and Productivity of CHO DG44 Cells; a New Insight into Amino Acid Profiles.

Davami F, Eghbalpour F, Nematollahi L, Barkhordari F, Mahboudi F.

Iran Biomed J. 2015;19(4):194-205. Epub 2015 Aug 1.

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