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Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis.

de la Higuera I, Ferrer-Orta C, Moreno E, de Ávila AI, Soria ME, Singh K, Caridi F, Sobrino F, Sarafianos SG, Perales C, Verdaguer N, Domingo E.

J Virol. 2018 Sep 26;92(20). pii: e01119-18. doi: 10.1128/JVI.01119-18. Print 2018 Oct 15.


Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.

Ferrer-Orta C, de la Higuera I, Caridi F, Sánchez-Aparicio MT, Moreno E, Perales C, Singh K, Sarafianos SG, Sobrino F, Domingo E, Verdaguer N.

J Virol. 2015 Jul;89(13):6848-59. doi: 10.1128/JVI.03283-14. Epub 2015 Apr 22.


Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin.

Arias A, Arnold JJ, Sierra M, Smidansky ED, Domingo E, Cameron CE.

J Virol. 2008 Dec;82(24):12346-55. doi: 10.1128/JVI.01297-08. Epub 2008 Oct 1.


Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin.

Ferrer-Orta C, Sierra M, Agudo R, de la Higuera I, Arias A, Pérez-Luque R, Escarmís C, Domingo E, Verdaguer N.

J Virol. 2010 Jun;84(12):6188-99. doi: 10.1128/JVI.02420-09. Epub 2010 Apr 14.


A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.

Agudo R, Ferrer-Orta C, Arias A, de la Higuera I, Perales C, Pérez-Luque R, Verdaguer N, Domingo E.

PLoS Pathog. 2010 Aug 26;6(8):e1001072. doi: 10.1371/journal.ppat.1001072.


Attenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity.

Rai DK, Diaz-San Segundo F, Campagnola G, Keith A, Schafer EA, Kloc A, de Los Santos T, Peersen O, Rieder E.

J Virol. 2017 Jul 12;91(15). pii: e00081-17. doi: 10.1128/JVI.00081-17. Print 2017 Aug 1.


Counteracting quasispecies adaptability: extinction of a ribavirin-resistant virus mutant by an alternative mutagenic treatment.

Perales C, Agudo R, Domingo E.

PLoS One. 2009;4(5):e5554. doi: 10.1371/journal.pone.0005554. Epub 2009 May 14.


Ribavirin-resistant variants of foot-and-mouth disease virus: the effect of restricted quasispecies diversity on viral virulence.

Zeng J, Wang H, Xie X, Li C, Zhou G, Yang D, Yu L.

J Virol. 2014 Apr;88(8):4008-20. doi: 10.1128/JVI.03594-13. Epub 2014 Jan 22.


Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: implications for error catastrophe.

Sierra M, Airaksinen A, González-López C, Agudo R, Arias A, Domingo E.

J Virol. 2007 Feb;81(4):2012-24. Epub 2006 Dec 6.


Foot-and-mouth disease virus low-fidelity polymerase mutants are attenuated.

Xie X, Wang H, Zeng J, Li C, Zhou G, Yang D, Yu L.

Arch Virol. 2014 Oct;159(10):2641-50. doi: 10.1007/s00705-014-2126-z. Epub 2014 Jun 3.


Mutant viral polymerase in the transition of virus to error catastrophe identifies a critical site for RNA binding.

Arias A, Agudo R, Ferrer-Orta C, Pérez-Luque R, Airaksinen A, Brocchi E, Domingo E, Verdaguer N, Escarmís C.

J Mol Biol. 2005 Nov 11;353(5):1021-32. Epub 2005 Sep 26.


Lethal mutagenesis of foot-and-mouth disease virus involves shifts in sequence space.

Perales C, Henry M, Domingo E, Wain-Hobson S, Vartanian JP.

J Virol. 2011 Dec;85(23):12227-40. doi: 10.1128/JVI.00716-11. Epub 2011 Sep 14.


Involvement of a joker mutation in a polymerase-independent lethal mutagenesis escape mechanism.

Agudo R, de la Higuera I, Arias A, Grande-Pérez A, Domingo E.

Virology. 2016 Jul;494:257-66. doi: 10.1016/j.virol.2016.04.023. Epub 2016 Apr 29.


Structural insights into replication initiation and elongation processes by the FMDV RNA-dependent RNA polymerase.

Ferrer-Orta C, Agudo R, Domingo E, Verdaguer N.

Curr Opin Struct Biol. 2009 Dec;19(6):752-8. doi: 10.1016/ Epub 2009 Nov 13. Review.


Foot-and-mouth disease virus type O specific mutations determine RNA-dependent RNA polymerase fidelity and virus attenuation.

Li C, Wang H, Yuan T, Woodman A, Yang D, Zhou G, Cameron CE, Yu L.

Virology. 2018 May;518:87-94. doi: 10.1016/j.virol.2018.01.030. Epub 2018 Feb 20.


Molecular characterization of a dual inhibitory and mutagenic activity of 5-fluorouridine triphosphate on viral RNA synthesis. Implications for lethal mutagenesis.

Agudo R, Arias A, Pariente N, Perales C, Escarmís C, Jorge A, Marina A, Domingo E.

J Mol Biol. 2008 Oct 10;382(3):652-66. doi: 10.1016/j.jmb.2008.07.033. Epub 2008 Jul 17.


Insights into RNA virus mutant spectrum and lethal mutagenesis events: replicative interference and complementation by multiple point mutants.

Perales C, Mateo R, Mateu MG, Domingo E.

J Mol Biol. 2007 Jun 15;369(4):985-1000. Epub 2007 Apr 1.


5-fluorouracil in lethal mutagenesis of foot-and-mouth disease virus.

Agudo R, Arias A, Domingo E.

Future Med Chem. 2009 Jun;1(3):529-39. doi: 10.4155/fmc.09.26. Review.


An antiviral mechanism investigated with ribavirin as an RNA virus mutagen for foot-and-mouth disease virus.

Gu CJ, Zheng CY, Zhang Q, Shi LL, Li Y, Qu SF.

J Biochem Mol Biol. 2006 Jan 31;39(1):9-15.


Topology of evolving, mutagenized viral populations: quasispecies expansion, compression, and operation of negative selection.

Ojosnegros S, Agudo R, Sierra M, Briones C, Sierra S, González-López C, Domingo E, Cristina J.

BMC Evol Biol. 2008 Jul 17;8:207. doi: 10.1186/1471-2148-8-207.

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