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Systems analysis of intracellular pH vulnerabilities for cancer therapy.

Persi E, Duran-Frigola M, Damaghi M, Roush WR, Aloy P, Cleveland JL, Gillies RJ, Ruppin E.

Nat Commun. 2018 Jul 31;9(1):2997. doi: 10.1038/s41467-018-05261-x.


Cy5.5-labeled pH low insertion peptide (pHLIP).

Shan L.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2009 Aug 8 [updated 2009 Nov 12].


64Cu-1,4,7,10-Tetraazacyclododecane-1,4,7-Tris-acetic acid-10-maleimidoethylacetamide-ACEQNPIYWARYADWLFTTPLLLLDLALLVDADEGTG.

Shan L.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2009 May 29 [updated 2009 Jul 27].


Smad5 acts as an intracellular pH messenger and maintains bioenergetic homeostasis.

Fang Y, Liu Z, Chen Z, Xu X, Xiao M, Yu Y, Zhang Y, Zhang X, Du Y, Jiang C, Zhao Y, Wang Y, Fan B, Terheyden-Keighley D, Liu Y, Shi L, Hui Y, Zhang X, Zhang B, Feng H, Ma L, Zhang Q, Jin G, Yang Y, Xiang B, Liu L, Zhang X.

Cell Res. 2017 Sep;27(9):1083-1099. doi: 10.1038/cr.2017.85. Epub 2017 Jul 4.


Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer.

Chiche J, Brahimi-Horn MC, Pouysségur J.

J Cell Mol Med. 2010 Apr;14(4):771-94. doi: 10.1111/j.1582-4934.2009.00994.x. Epub 2009 Dec 8. Review.


Utilizing hydrogen sulfide as a novel anti-cancer agent by targeting cancer glycolysis and pH imbalance.

Lee ZW, Teo XY, Tay EY, Tan CH, Hagen T, Moore PK, Deng LW.

Br J Pharmacol. 2014 Sep;171(18):4322-36. doi: 10.1111/bph.12773. Epub 2014 Jul 2.


Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells.

Parks SK, Cormerais Y, Durivault J, Pouyssegur J.

Oncotarget. 2017 Feb 7;8(6):10225-10237. doi: 10.18632/oncotarget.14379.


Intracellular pH Regulation in iPSCs-derived Astrocytes from Subjects with Chronic Mountain Sickness.

Yao H, Zhao H, Wang J, Haddad GG.

Neuroscience. 2018 Apr 1;375:25-33. doi: 10.1016/j.neuroscience.2018.02.008. Epub 2018 Feb 10.


Extracellular alkaline pH leads to increased metastatic potential of estrogen receptor silenced endocrine resistant breast cancer cells.

Khajah MA, Almohri I, Mathew PM, Luqmani YA.

PLoS One. 2013 Oct 1;8(10):e76327. doi: 10.1371/journal.pone.0076327. eCollection 2013.


Impact of extracellular acidosis on intracellular pH control and cell signaling in tumor cells.

Riemann A, Ihling A, Schneider B, Gekle M, Thews O.

Adv Exp Med Biol. 2013;789:221-228. doi: 10.1007/978-1-4614-7411-1_30.


Functional characterization of transmembrane intracellular pH regulators and mechanism of alcohol-induced intracellular acidosis in human umbilical cord blood stem cell-like cells.

Tsai YT, Liu JY, Lee CY, Tsai CS, Chen MH, Ou CC, Chen WH, Loh SH.

J Cardiovasc Pharmacol. 2011 Dec;58(6):589-601. doi: 10.1097/FJC.0b013e3182300228.


The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela

Cardone RA, Alfarouk KO, Elliott RL, Alqahtani SS, Ahmed SBM, Aljarbou AN, Greco MR, Cannone S, Reshkin SJ.

Int J Mol Sci. 2019 Jul 28;20(15). pii: E3694. doi: 10.3390/ijms20153694. Review.


Preferential intracellular pH regulation: hypotheses and perspectives.

Shartau RB, Baker DW, Crossley DA 2nd, Brauner CJ.

J Exp Biol. 2016 Aug 1;219(Pt 15):2235-44. doi: 10.1242/jeb.126631. Review.


Causes and consequences of acidic pH in tumors: a magnetic resonance study.

Stubbs M, McSheehy PM, Griffiths JR.

Adv Enzyme Regul. 1999;39:13-30.


Chemotherapy with cisplatin: insights into intracellular pH and metabolic landscape of cancer cells in vitro and in vivo.

Shirmanova MV, Druzhkova IN, Lukina MM, Dudenkova VV, Ignatova NI, Snopova LB, Shcheslavskiy VI, Belousov VV, Zagaynova EV.

Sci Rep. 2017 Aug 21;7(1):8911. doi: 10.1038/s41598-017-09426-4.


Acid pH in tumors and its potential for therapeutic exploitation.

Tannock IF, Rotin D.

Cancer Res. 1989 Aug 15;49(16):4373-84.

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