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Items: 1 to 20 of 121

1.

Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity.

Kleiner S, Gomez D, Megra B, Na E, Bhavsar R, Cavino K, Xin Y, Rojas J, Dominguez-Gutierrez G, Zambrowicz B, Carrat G, Chabosseau P, Hu M, Murphy AJ, Yancopoulos GD, Rutter GA, Gromada J.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7642-E7649. doi: 10.1073/pnas.1721418115. Epub 2018 Jul 23.

2.

Genetic, Epigenetic and Biological Effects of Zinc Transporter (SLC30A8) in Type 1 and Type 2 Diabetes.

Gu HF.

Curr Diabetes Rev. 2017;13(2):132-140. doi: 10.2174/1573399812666151123104540. Review.

PMID:
26593983
3.

The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance.

Tamaki M, Fujitani Y, Hara A, Uchida T, Tamura Y, Takeno K, Kawaguchi M, Watanabe T, Ogihara T, Fukunaka A, Shimizu T, Mita T, Kanazawa A, Imaizumi MO, Abe T, Kiyonari H, Hojyo S, Fukada T, Kawauchi T, Nagamatsu S, Hirano T, Kawamori R, Watada H.

J Clin Invest. 2013 Oct;123(10):4513-24. doi: 10.1172/JCI68807. Epub 2013 Sep 24.

4.

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA.

Diabetes. 2009 Sep;58(9):2070-83. doi: 10.2337/db09-0551. Epub 2009 Jun 19.

5.

Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion.

Syring KE, Boortz KA, Oeser JK, Ustione A, Platt KA, Shadoan MK, McGuinness OP, Piston DW, Powell DR, O'Brien RM.

Endocrinology. 2016 Dec;157(12):4534-4541. Epub 2016 Oct 18.

6.

Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion.

Pound LD, Sarkar SA, Benninger RK, Wang Y, Suwanichkul A, Shadoan MK, Printz RL, Oeser JK, Lee CE, Piston DW, McGuinness OP, Hutton JC, Powell DR, O'Brien RM.

Biochem J. 2009 Jul 15;421(3):371-6. doi: 10.1042/BJ20090530.

7.

Zinc transporter 8 (ZnT8) and β cell function.

Davidson HW, Wenzlau JM, O'Brien RM.

Trends Endocrinol Metab. 2014 Aug;25(8):415-24. doi: 10.1016/j.tem.2014.03.008. Epub 2014 Apr 18. Review.

8.

Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance.

Mitchell RK, Hu M, Chabosseau PL, Cane MC, Meur G, Bellomo EA, Carzaniga R, Collinson LM, Li WH, Hodson DJ, Rutter GA.

Mol Endocrinol. 2016 Jan;30(1):77-91. doi: 10.1210/me.2015-1227. Epub 2015 Nov 19.

9.

SLC30A8 mutations in type 2 diabetes.

Rutter GA, Chimienti F.

Diabetologia. 2015 Jan;58(1):31-6. doi: 10.1007/s00125-014-3405-7. Epub 2014 Oct 7. Review.

PMID:
25287711
10.

The Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 is a Pseudogene in Guinea Pigs Potentially Contributing to Low Guinea Pig Islet Zinc Content.

Syring KE, Bosma KJ, Oeser JK, Shiota M, O'Brien RM.

J Mol Evol. 2018 Dec;86(9):613-617. doi: 10.1007/s00239-018-9873-5. Epub 2018 Nov 3.

PMID:
30392157
11.

Zinc and diabetes.

Chabosseau P, Rutter GA.

Arch Biochem Biophys. 2016 Dec 1;611:79-85. doi: 10.1016/j.abb.2016.05.022. Epub 2016 Jun 1. Review.

12.

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.

Wijesekara N, Dai FF, Hardy AB, Giglou PR, Bhattacharjee A, Koshkin V, Chimienti F, Gaisano HY, Rutter GA, Wheeler MB.

Diabetologia. 2010 Aug;53(8):1656-68. doi: 10.1007/s00125-010-1733-9. Epub 2010 Apr 28.

13.

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion.

Solomou A, Meur G, Bellomo E, Hodson DJ, Tomas A, Li SM, Philippe E, Herrera PL, Magnan C, Rutter GA.

J Biol Chem. 2015 Aug 28;290(35):21432-42. doi: 10.1074/jbc.M115.645291. Epub 2015 Jul 15.

14.

Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets.

Cauchi S, Del Guerra S, Choquet H, D'Aleo V, Groves CJ, Lupi R, McCarthy MI, Froguel P, Marchetti P.

Mol Genet Metab. 2010 May;100(1):77-82. doi: 10.1016/j.ymgme.2010.01.001. Epub 2010 Jan 15.

PMID:
20138556
15.

The influence of rare genetic variation in SLC30A8 on diabetes incidence and β-cell function.

Billings LK, Jablonski KA, Ackerman RJ, Taylor A, Fanelli RR, McAteer JB, Guiducci C, Delahanty LM, Dabelea D, Kahn SE, Franks PW, Hanson RL, Maruthur NM, Shuldiner AR, Mayer-Davis EJ, Knowler WC, Florez JC; Diabetes Prevention Program Research Group, Rockville.

J Clin Endocrinol Metab. 2014 May;99(5):E926-30. doi: 10.1210/jc.2013-2378. Epub 2014 Jan 28.

16.

Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion.

Fu Y, Tian W, Pratt EB, Dirling LB, Shyng SL, Meshul CK, Cohen DM.

PLoS One. 2009 May 25;4(5):e5679. doi: 10.1371/journal.pone.0005679.

17.

SLC30A8 polymorphism and BMI complement HLA-A*24 as risk factors for poor graft function in islet allograft recipients.

Balke EM, Demeester S, Lee D, Gillard P, Hilbrands R, Van de Velde U, Van der Auwera BJ, Ling Z, Roep BO, Pipeleers DG, Keymeulen B, Gorus FK.

Diabetologia. 2018 Jul;61(7):1623-1632. doi: 10.1007/s00125-018-4609-z. Epub 2018 Apr 20.

PMID:
29679103
18.

Think zinc: New roles for zinc in the control of insulin secretion.

Rutter GA.

Islets. 2010 Jan-Feb;2(1):49-50. doi: 10.4161/isl.2.1.10259. Review.

PMID:
21099294
19.

The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background.

Pound LD, Sarkar SA, Ustione A, Dadi PK, Shadoan MK, Lee CE, Walters JA, Shiota M, McGuinness OP, Jacobson DA, Piston DW, Hutton JC, Powell DR, O'Brien RM.

PLoS One. 2012;7(7):e40972. doi: 10.1371/journal.pone.0040972. Epub 2012 Jul 19.

20.

The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.

Gerber PA, Rutter GA.

Antioxid Redox Signal. 2017 Apr 1;26(10):501-518. doi: 10.1089/ars.2016.6755. Epub 2016 Jun 30. Review.

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