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Results by year

Year	Number of Results
2006	2
2007	2
2008	4
2009	3
2010	13
2011	13
2012	33
2013	25
2014	35
2015	17
2016	20
2017	22
2018	43
2019	41
2020	93
2021	105
2022	103
2023	32
2024	0

534 results

Page of 54

Results by year

Page 1

Unusually long-term responses to vemurafenib in BRAF V600E mutated colon and thyroid cancers followed by the development of rare RAS activating mutations.

Ofir Dovrat T, Sokol E, Frampton G, Shachar E, Pelles S, Geva R, Wolf I. Ofir Dovrat T, et al. Cancer Biol Ther. 2018;19(10):871-874. doi: 10.1080/15384047.2018.1480289. Epub 2018 Jul 23. Cancer Biol Ther. 2018. PMID: 30036146 Free PMC article.

Long-term vemurafenib treatment drives inhibitor resistance through a spontaneous KRAS G12D mutation in a BRAF V600E papillary thyroid carcinoma model.

Danysh BP, Rieger EY, Sinha DK, Evers CV, Cote GJ, Cabanillas ME, Hofmann MC. Danysh BP, et al. Oncotarget. 2016 May 24;7(21):30907-23. doi: 10.18632/oncotarget.9023. Oncotarget. 2016. PMID: 27127178 Free PMC article.

Clinical responses to vemurafenib in patients with metastatic papillary thyroid cancer harboring BRAF(V600E) mutation.

Kim KB, Cabanillas ME, Lazar AJ, Williams MD, Sanders DL, Ilagan JL, Nolop K, Lee RJ, Sherman SI. Kim KB, et al. Thyroid. 2013 Oct;23(10):1277-83. doi: 10.1089/thy.2013.0057. Epub 2013 Jul 17. Thyroid. 2013. PMID: 23489023 Free PMC article. Clinical Trial.

Acquired Secondary RAS Mutation in BRAF^V600E-Mutated Thyroid Cancer Patients Treated with BRAF Inhibitors.

Cabanillas ME, Dadu R, Iyer P, Wanland KB, Busaidy NL, Ying A, Gule-Monroe M, Wang JR, Zafereo M, Hofmann MC. Cabanillas ME, et al. Thyroid. 2020 Sep;30(9):1288-1296. doi: 10.1089/thy.2019.0514. Epub 2020 May 7. Thyroid. 2020. PMID: 32216548 Free PMC article.

Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model.

Duquette M, Sadow PM, Husain A, Sims JN, Antonello ZA, Fischer AH, Song C, Castellanos-Rizaldos E, Makrigiorgos GM, Kurebayashi J, Nose V, Van Hummelen P, Bronson RT, Vinco M, Giordano TJ, Dias-Santagata D, Pandolfi PP, Nucera C. Duquette M, et al. Oncotarget. 2015 Dec 15;6(40):42445-67. doi: 10.18632/oncotarget.6442. Oncotarget. 2015. PMID: 26636651 Free PMC article.

BRAF Fusion as a Novel Mechanism of Acquired Resistance to Vemurafenib in BRAF^V600E Mutant Melanoma.

Kulkarni A, Al-Hraishawi H, Simhadri S, Hirshfield KM, Chen S, Pine S, Jeyamohan C, Sokol L, Ali S, Teo ML, White E, Rodriguez-Rodriguez L, Mehnert JM, Ganesan S. Kulkarni A, et al. Clin Cancer Res. 2017 Sep 15;23(18):5631-5638. doi: 10.1158/1078-0432.CCR-16-0758. Epub 2017 May 24. Clin Cancer Res. 2017. PMID: 28539463

Combination Treatment with the BRAF^V600E Inhibitor Vemurafenib and the BH3 Mimetic Navitoclax for BRAF-Mutant Thyroid Carcinoma.

Jeong JH, Oh JM, Jeong SY, Lee SW, Lee J, Ahn BC. Jeong JH, et al. Thyroid. 2019 Apr;29(4):540-548. doi: 10.1089/thy.2018.0511. Thyroid. 2019. PMID: 30869573

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.

Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, Chodon T, Nelson SF, McArthur G, Sosman JA, Ribas A, Lo RS. Nazarian R, et al. Nature. 2010 Dec 16;468(7326):973-7. doi: 10.1038/nature09626. Epub 2010 Nov 24. Nature. 2010. PMID: 21107323 Free PMC article.

Fine-Tuning Lipid Metabolism by Targeting Mitochondria-Associated Acetyl-CoA-Carboxylase 2 in BRAF^V600E Papillary Thyroid Carcinoma.

Valvo V, Iesato A, Kavanagh TR, Priolo C, Zsengeller Z, Pontecorvi A, Stillman IE, Burke SD, Liu X, Nucera C. Valvo V, et al. Thyroid. 2021 Sep;31(9):1335-1358. doi: 10.1089/thy.2020.0311. Epub 2021 Mar 3. Thyroid. 2021. PMID: 33107403 Free PMC article.

Vemurafenib in patients with BRAF(V600E)-positive metastatic or unresectable papillary thyroid cancer refractory to radioactive iodine: a non-randomised, multicentre, open-label, phase 2 trial.

Brose MS, Cabanillas ME, Cohen EE, Wirth LJ, Riehl T, Yue H, Sherman SI, Sherman EJ. Brose MS, et al. Lancet Oncol. 2016 Sep;17(9):1272-82. doi: 10.1016/S1470-2045(16)30166-8. Epub 2016 Jul 23. Lancet Oncol. 2016. PMID: 27460442 Free PMC article. Clinical Trial.

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