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Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm.

Strasser MK, Hoppe PS, Loeffler D, Kokkaliaris KD, Schroeder T, Theis FJ, Marr C.

Nat Commun. 2018 Jul 12;9(1):2697. doi: 10.1038/s41467-018-05037-3.


Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.

Hoppe PS, Schwarzfischer M, Loeffler D, Kokkaliaris KD, Hilsenbeck O, Moritz N, Endele M, Filipczyk A, Gambardella A, Ahmed N, Etzrodt M, Coutu DL, Rieger MA, Marr C, Strasser MK, Schauberger B, Burtscher I, Ermakova O, Bürger A, Lickert H, Nerlov C, Theis FJ, Schroeder T.

Nature. 2016 Jul 14;535(7611):299-302. doi: 10.1038/nature18320.


The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1γ.

Monteiro R, Pouget C, Patient R.

EMBO J. 2011 Mar 16;30(6):1093-103. doi: 10.1038/emboj.2011.34. Epub 2011 Feb 18.


Transcriptome-wide noise controls lineage choice in mammalian progenitor cells.

Chang HH, Hemberg M, Barahona M, Ingber DE, Huang S.

Nature. 2008 May 22;453(7194):544-7. doi: 10.1038/nature06965.


Computational modeling of the hematopoietic erythroid-myeloid switch reveals insights into cooperativity, priming, and irreversibility.

Chickarmane V, Enver T, Peterson C.

PLoS Comput Biol. 2009 Jan;5(1):e1000268. doi: 10.1371/journal.pcbi.1000268. Epub 2009 Jan 23.


Lymphoid lineage fate decision of hematopoietic stem cells.

Akashi K.

Ann N Y Acad Sci. 2009 Sep;1176:18-25. doi: 10.1111/j.1749-6632.2009.04570.x.


Limit-cycle oscillatory coexpression of cross-inhibitory transcription factors: a model mechanism for lineage promiscuity.

Bokes P, King JR.

Math Med Biol. 2019 Mar 14;36(1):113-137. doi: 10.1093/imammb/dqy003.


Defining the pathways of early adult hematopoiesis.

Murre C.

Cell Stem Cell. 2007 Oct 11;1(4):357-8. doi: 10.1016/j.stem.2007.09.008.


M-CSF instructs myeloid lineage fate in single haematopoietic stem cells.

Mossadegh-Keller N, Sarrazin S, Kandalla PK, Espinosa L, Stanley ER, Nutt SL, Moore J, Sieweke MH.

Nature. 2013 May 9;497(7448):239-43. doi: 10.1038/nature12026. Epub 2013 Apr 10.


Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages.

Arinobu Y, Mizuno S, Chong Y, Shigematsu H, Iino T, Iwasaki H, Graf T, Mayfield R, Chan S, Kastner P, Akashi K.

Cell Stem Cell. 2007 Oct 11;1(4):416-27. doi: 10.1016/j.stem.2007.07.004.


Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89.

Li X, Romain RD, Park D, Scadden DT, Merchant JL, Arnaout MA.

Stem Cells. 2014 Mar;32(3):791-801. doi: 10.1002/stem.1598.


The importance of PU.1 concentration in hematopoietic lineage commitment and maturation.

Dahl R, Simon MC.

Blood Cells Mol Dis. 2003 Sep-Oct;31(2):229-33. Review.


A bistable genetic switch which does not require high co-operativity at the promoter: a two-timescale model for the PU.1-GATA-1 interaction.

Bokes P, King JR, Loose M.

Math Med Biol. 2009 Jun;26(2):117-32. doi: 10.1093/imammb/dqn026. Epub 2009 Jan 29.


Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate.

Chou ST, Khandros E, Bailey LC, Nichols KE, Vakoc CR, Yao Y, Huang Z, Crispino JD, Hardison RC, Blobel GA, Weiss MJ.

Blood. 2009 Jul 30;114(5):983-94. doi: 10.1182/blood-2009-03-207944. Epub 2009 Jun 2.


The erythroid/myeloid lineage fate paradigm takes a new player.

Xu J, Orkin SH.

EMBO J. 2011 Mar 16;30(6):983-5. doi: 10.1038/emboj.2011.45. No abstract available.


PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis.

Gupta P, Gurudutta GU, Saluja D, Tripathi RP.

J Cell Mol Med. 2009 Nov-Dec;13(11-12):4349-63. doi: 10.1111/j.1582-4934.2009.00757.x. Epub 2009 Apr 6. Review.


Transient expression of PU.1 commits multipotent progenitors to a myeloid fate whereas continued expression favors macrophage over granulocyte differentiation.

McIvor Z, Hein S, Fiegler H, Schroeder T, Stocking C, Just U, Cross M.

Exp Hematol. 2003 Jan;31(1):39-47.


E2A Antagonizes PU.1 Activity through Inhibition of DNA Binding.

Rogers JH, Owens KS, Kurkewich J, Klopfenstein N, Iyer SR, Simon MC, Dahl R.

Biomed Res Int. 2016;2016:3983686. doi: 10.1155/2016/3983686. Epub 2016 Jan 28.


Stem cell fate specification: role of master regulatory switch transcription factor PU.1 in differential hematopoiesis.

Gangenahalli GU, Gupta P, Saluja D, Verma YK, Kishore V, Chandra R, Sharma RK, Ravindranath T.

Stem Cells Dev. 2005 Apr;14(2):140-52. Review.


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