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Items: 1 to 20 of 142

1.

Urea cycle dysregulation in non-alcoholic fatty liver disease.

De Chiara F, Heebøll S, Marrone G, Montoliu C, Hamilton-Dutoit S, Ferrandez A, Andreola F, Rombouts K, Grønbæk H, Felipo V, Gracia-Sancho J, Mookerjee RP, Vilstrup H, Jalan R, Thomsen KL.

J Hepatol. 2018 Oct;69(4):905-915. doi: 10.1016/j.jhep.2018.06.023. Epub 2018 Jul 5.

PMID:
29981428
2.

Experimental nonalcoholic steatohepatitis compromises ureagenesis, an essential hepatic metabolic function.

Thomsen KL, Grønbæk H, Glavind E, Hebbard L, Jessen N, Clouston A, George J, Vilstrup H.

Am J Physiol Gastrointest Liver Physiol. 2014 Aug 1;307(3):G295-301. doi: 10.1152/ajpgi.00036.2014. Epub 2014 Jun 12.

3.

Y-box binding protein-1 down-regulates expression of carbamoyl phosphate synthetase-I by suppressing CCAAT enhancer-binding protein-alpha function in mice.

Chen YR, Sekine K, Nakamura K, Yanai H, Tanaka M, Miyajima A.

Gastroenterology. 2009 Jul;137(1):330-40. doi: 10.1053/j.gastro.2009.02.064. Epub 2009 Mar 9.

PMID:
19272383
4.

PGC-1α Promotes Ureagenesis in Mouse Periportal Hepatocytes through SIRT3 and SIRT5 in Response to Glucagon.

Li L, Zhang P, Bao Z, Wang T, Liu S, Huang F.

Sci Rep. 2016 Apr 7;6:24156. doi: 10.1038/srep24156.

5.

Ammonia: A novel target for the treatment of non-alcoholic steatohepatitis.

Thomsen KL, De Chiara F, Rombouts K, Vilstrup H, Andreola F, Mookerjee RP, Jalan R.

Med Hypotheses. 2018 Apr;113:91-97. doi: 10.1016/j.mehy.2018.02.010. Epub 2018 Feb 15.

PMID:
29523305
6.

Non-alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion.

Eriksen PL, Vilstrup H, Rigbolt K, Suppli MP, Sørensen M, Heebøll S, Veidal SS, Knop FK, Thomsen KL.

Liver Int. 2019 Nov;39(11):2094-2101. doi: 10.1111/liv.14205. Epub 2019 Sep 5.

PMID:
31386258
7.

DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma.

Liu H, Dong H, Robertson K, Liu C.

Am J Pathol. 2011 Feb;178(2):652-61. doi: 10.1016/j.ajpath.2010.10.023.

8.

Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts.

van Straten G, van Steenbeek FG, Grinwis GC, Favier RP, Kummeling A, van Gils IH, Fieten H, Groot Koerkamp MJ, Holstege FC, Rothuizen J, Spee B.

PLoS One. 2014 Jun 19;9(6):e100077. doi: 10.1371/journal.pone.0100077. eCollection 2014.

9.

The activity of the carbamoyl phosphate synthase 1 promoter in human liver-derived cells is dependent on hepatocyte nuclear factor 3-beta.

Chen Z, Tang N, Wang X, Chen Y.

J Cell Mol Med. 2017 Sep;21(9):2036-2045. doi: 10.1111/jcmm.13123. Epub 2017 Mar 8.

10.

Gene expression and activity of urea cycle enzymes of rat hepatocytes cold stored up to 120h in University of Wisconsin solution.

Almada L, Bellarosa C, Giraudi P, Mamprín M, Mediavilla M, Guibert E, Tiribelli C, Rodríguez J.

Cryobiology. 2006 Jun;52(3):393-400.

PMID:
16546154
11.

Fatal hyperammonemia and carbamoyl phosphate synthetase 1 (CPS1) deficiency following high-dose chemotherapy and autologous hematopoietic stem cell transplantation.

Laemmle A, Hahn D, Hu L, Rüfenacht V, Gautschi M, Leibundgut K, Nuoffer JM, Häberle J.

Mol Genet Metab. 2015 Mar;114(3):438-44. doi: 10.1016/j.ymgme.2015.01.002. Epub 2015 Jan 24.

PMID:
25639153
12.

Histopathological findings in livers of patients with urea cycle disorders.

Yaplito-Lee J, Chow CW, Boneh A.

Mol Genet Metab. 2013 Mar;108(3):161-5. doi: 10.1016/j.ymgme.2013.01.006. Epub 2013 Jan 23.

PMID:
23403242
13.

Genetic variation in the urea cycle: a model resource for investigating key candidate genes for common diseases.

Mitchell S, Ellingson C, Coyne T, Hall L, Neill M, Christian N, Higham C, Dobrowolski SF, Tuchman M, Summar M; Urea Cycle Disorder Consortium.

Hum Mutat. 2009 Jan;30(1):56-60. doi: 10.1002/humu.20813.

PMID:
18666241
14.

Conditional disruption of hepatic carbamoyl phosphate synthetase 1 in mice results in hyperammonemia without orotic aciduria and can be corrected by liver-directed gene therapy.

Khoja S, Nitzahn M, Hermann K, Truong B, Borzone R, Willis B, Rudd M, Palmer DJ, Ng P, Brunetti-Pierri N, Lipshutz GS.

Mol Genet Metab. 2018 Aug;124(4):243-253. doi: 10.1016/j.ymgme.2018.04.001. Epub 2018 Apr 12.

15.

Non-Alcoholic Fatty Liver Disease.

Engin A.

Adv Exp Med Biol. 2017;960:443-467. doi: 10.1007/978-3-319-48382-5_19. Review.

PMID:
28585211
16.

Changes of activity and mRNA expression of urea cycle enzymes in the liver of developing Holstein calves.

Takagi M, Yonezawa T, Haga S, Shingu H, Kobayashi Y, Takahashi T, Ohtani Y, Obara Y, Katoh K.

J Anim Sci. 2008 Jul;86(7):1526-32. doi: 10.2527/jas.2007-0799. Epub 2008 Mar 14.

PMID:
18344300
17.

Acute metabolic decompensation due to influenza in a mouse model of ornithine transcarbamylase deficiency.

McGuire PJ, Tarasenko TN, Wang T, Levy E, Zerfas PM, Moran T, Lee HS, Bequette BJ, Diaz GA.

Dis Model Mech. 2014 Feb;7(2):205-13. doi: 10.1242/dmm.013003. Epub 2013 Nov 21.

18.

Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice.

Xu B, Jiang M, Chu Y, Wang W, Chen D, Li X, Zhang Z, Zhang D, Fan D, Nie Y, Shao F, Wu K, Liang J.

J Hepatol. 2018 Apr;68(4):773-782. doi: 10.1016/j.jhep.2017.11.040. Epub 2017 Dec 20.

PMID:
29273476
19.

Oleic acid protects saturated fatty acid mediated lipotoxicity in hepatocytes and rat of non-alcoholic steatohepatitis.

Chen X, Li L, Liu X, Luo R, Liao G, Li L, Liu J, Cheng J, Lu Y, Chen Y.

Life Sci. 2018 Jun 15;203:291-304. doi: 10.1016/j.lfs.2018.04.022. Epub 2018 Apr 27.

PMID:
29709653

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