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Items: 1 to 20 of 73

1.

Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes.

Sharma A, Halu A, Decano JL, Padi M, Liu YY, Prasad RB, Fadista J, Santolini M, Menche J, Weiss ST, Vidal M, Silverman EK, Aikawa M, Barabási AL, Groop L, Loscalzo J.

NPJ Syst Biol Appl. 2018 Jul 3;4:25. doi: 10.1038/s41540-018-0057-0. eCollection 2018.

2.

Genome-wide meta-analysis of genetic susceptible genes for Type 2 Diabetes.

Hale PJ, López-Yunez AM, Chen JY.

BMC Syst Biol. 2012;6 Suppl 3:S16. doi: 10.1186/1752-0509-6-S3-S16. Epub 2012 Dec 17.

3.

Pancreatic Islet Protein Complexes and Their Dysregulation in Type 2 Diabetes.

Pedersen HK, Gudmundsdottir V, Brunak S.

Front Genet. 2017 Apr 20;8:43. doi: 10.3389/fgene.2017.00043. eCollection 2017.

4.

Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis.

Volkov P, Bacos K, Ofori JK, Esguerra JL, Eliasson L, Rönn T, Ling C.

Diabetes. 2017 Apr;66(4):1074-1085. doi: 10.2337/db16-0996. Epub 2017 Jan 4.

5.

The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis.

van de Bunt M, Gaulton KJ, Parts L, Moran I, Johnson PR, Lindgren CM, Ferrer J, Gloyn AL, McCarthy MI.

PLoS One. 2013;8(1):e55272. doi: 10.1371/journal.pone.0055272. Epub 2013 Jan 25.

6.

Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data.

Fernández-Tajes J, Gaulton KJ, van de Bunt M, Torres J, Thurner M, Mahajan A, Gloyn AL, Lage K, McCarthy MI.

Genome Med. 2019 Mar 26;11(1):19. doi: 10.1186/s13073-019-0628-8.

7.

Integrating pathway analysis and genetics of gene expression for genome-wide association studies.

Zhong H, Yang X, Kaplan LM, Molony C, Schadt EE.

Am J Hum Genet. 2010 Apr 9;86(4):581-91. doi: 10.1016/j.ajhg.2010.02.020. Epub 2010 Mar 25.

8.

Interactome-transcriptome analysis discovers signatures complementary to GWAS Loci of Type 2 Diabetes.

Li JW, Lee HM, Wang Y, Tong AH, Yip KY, Tsui SK, Lok S, Ozaki R, Luk AO, Kong AP, So WY, Ma RC, Chan JC, Chan TF.

Sci Rep. 2016 Oct 18;6:35228. doi: 10.1038/srep35228.

9.

Identification of key gene pathways and coexpression networks of islets in human type 2 diabetes.

Li L, Pan Z, Yang S, Shan W, Yang Y.

Diabetes Metab Syndr Obes. 2018 Sep 28;11:553-563. doi: 10.2147/DMSO.S178894. eCollection 2018.

10.

The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets.

Keller MP, Paul PK, Rabaglia ME, Stapleton DS, Schueler KL, Broman AT, Ye SI, Leng N, Brandon CJ, Neto EC, Plaisier CL, Simonett SP, Kebede MA, Sheynkman GM, Klein MA, Baliga NS, Smith LM, Broman KW, Yandell BS, Kendziorski C, Attie AD.

PLoS Genet. 2016 Dec 9;12(12):e1006466. doi: 10.1371/journal.pgen.1006466. eCollection 2016 Dec.

11.

An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes.

Sharma PR, Mackey AJ, Dejene EA, Ramadan JW, Langefeld CD, Palmer ND, Taylor KD, Wagenknecht LE, Watanabe RM, Rich SS, Nunemaker CS.

Endocrinology. 2015 Sep;156(9):3147-56. doi: 10.1210/en.2015-1203. Epub 2015 May 27.

12.

Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.

Dayeh T, Volkov P, Salö S, Hall E, Nilsson E, Olsson AH, Kirkpatrick CL, Wollheim CB, Eliasson L, Rönn T, Bacos K, Ling C.

PLoS Genet. 2014 Mar 6;10(3):e1004160. doi: 10.1371/journal.pgen.1004160. eCollection 2014 Mar.

13.

Gene set enrichment in eQTL data identifies novel annotations and pathway regulators.

Wu C, Delano DL, Mitro N, Su SV, Janes J, McClurg P, Batalov S, Welch GL, Zhang J, Orth AP, Walker JR, Glynne RJ, Cooke MP, Takahashi JS, Shimomura K, Kohsaka A, Bass J, Saez E, Wiltshire T, Su AI.

PLoS Genet. 2008 May 9;4(5):e1000070. doi: 10.1371/journal.pgen.1000070.

14.

TCF7L2 is a master regulator of insulin production and processing.

Zhou Y, Park SY, Su J, Bailey K, Ottosson-Laakso E, Shcherbina L, Oskolkov N, Zhang E, Thevenin T, Fadista J, Bennet H, Vikman P, Wierup N, Fex M, Rung J, Wollheim C, Nobrega M, Renström E, Groop L, Hansson O.

Hum Mol Genet. 2014 Dec 15;23(24):6419-31. doi: 10.1093/hmg/ddu359. Epub 2014 Jul 11.

15.

Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility.

Das SK, Sharma NK.

World J Diabetes. 2014 Apr 15;5(2):97-114. doi: 10.4239/wjd.v5.i2.97. Review.

16.

High-Resolution Genetic Maps Identify Multiple Type 2 Diabetes Loci at Regulatory Hotspots in African Americans and Europeans.

Lau W, Andrew T, Maniatis N.

Am J Hum Genet. 2017 May 4;100(5):803-816. doi: 10.1016/j.ajhg.2017.04.007.

17.

Exploring the pathogenetic association between schizophrenia and type 2 diabetes mellitus diseases based on pathway analysis.

Liu Y, Li Z, Zhang M, Deng Y, Yi Z, Shi T.

BMC Med Genomics. 2013;6 Suppl 1:S17. doi: 10.1186/1755-8794-6-S1-S17. Epub 2013 Jan 23.

18.

A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell.

Kulzer JR, Stitzel ML, Morken MA, Huyghe JR, Fuchsberger C, Kuusisto J, Laakso M, Boehnke M, Collins FS, Mohlke KL.

Am J Hum Genet. 2014 Feb 6;94(2):186-97. doi: 10.1016/j.ajhg.2013.12.011. Epub 2014 Jan 16.

19.

Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia.

Taneera J, Fadista J, Ahlqvist E, Atac D, Ottosson-Laakso E, Wollheim CB, Groop L.

Hum Mol Genet. 2015 Apr 1;24(7):1945-55. doi: 10.1093/hmg/ddu610. Epub 2014 Dec 8.

PMID:
25489054
20.

Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity.

Sajuthi SP, Sharma NK, Chou JW, Palmer ND, McWilliams DR, Beal J, Comeau ME, Ma L, Calles-Escandon J, Demons J, Rogers S, Cherry K, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Ng MC, Maruthur NM, Patel SR, Bielak LF, Lange LA, Guo X, Sale MM, Chan KH, Monda KL, Chen GK, Taylor K, Palmer C, Edwards TL, North KE, Haiman CA, Bowden DW, Freedman BI, Langefeld CD, Das SK.

Hum Genet. 2016 Aug;135(8):869-80. doi: 10.1007/s00439-016-1680-8. Epub 2016 May 19.

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