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TGF-β Determines the Pro-migratory Potential of bFGF Signaling in Medulloblastoma.

Santhana Kumar K, Neve A, Guerreiro Stucklin AS, Kuzan-Fischer CM, Rushing EJ, Taylor MD, Tripolitsioti D, Behrmann L, Kirschenbaum D, Grotzer MA, Baumgartner M.

Cell Rep. 2018 Jun 26;23(13):3798-3812.e8. doi: 10.1016/j.celrep.2018.05.083.


EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

Wu Y, Chen Z, Ullrich A.

Biol Chem. 2003 Aug;384(8):1215-26.


Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma.

Zhang K, Chu K, Wu X, Gao H, Wang J, Yuan YC, Loera S, Ho K, Wang Y, Chow W, Un F, Chu P, Yen Y.

Cancer Res. 2013 Feb 15;73(4):1298-307. doi: 10.1158/0008-5472.CAN-12-2086. Epub 2013 Feb 7.


Neural and glial-mediated effects of growth factors acting via tyrosine kinase receptors on luteinizing hormone-releasing hormone neurons.

Voigt P, Ma YJ, Gonzalez D, Fahrenbach WH, Wetsel WC, Berg-von der Emde K, Hill DF, Taylor KG, Costa ME, Seidah NG, Ojeda SR.

Endocrinology. 1996 Jun;137(6):2593-605.


Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma.

Hanes R, Munthe E, Grad I, Han J, Karlsen I, McCormack E, Meza-Zepeda LA, Stratford EW, Myklebost O.

Cells. 2019 Feb 21;8(2). pii: E189. doi: 10.3390/cells8020189.


FGF represses metastasis of neuroblastoma regulated by MYCN and TGF-β1 induced LMO1 via control of let-7 expression.

Wang XH, Wu HY, Gao J, Wang XH, Gao TH, Zhang SF.

Brain Res. 2019 Feb 1;1704:219-228. doi: 10.1016/j.brainres.2018.10.015. Epub 2018 Oct 12.


MAP4K4 controlled integrin β1 activation and c-Met endocytosis are associated with invasive behavior of medulloblastoma cells.

Tripolitsioti D, Kumar KS, Neve A, Migliavacca J, Capdeville C, Rushing EJ, Ma M, Kijima N, Sharma A, Pruschy M, McComb S, Taylor MD, Grotzer MA, Baumgartner M.

Oncotarget. 2018 May 1;9(33):23220-23236. doi: 10.18632/oncotarget.25294. eCollection 2018 May 1.


Canonical transient receptor potential 1 plays a role in basic fibroblast growth factor (bFGF)/FGF receptor-1-induced Ca2+ entry and embryonic rat neural stem cell proliferation.

Fiorio Pla A, Maric D, Brazer SC, Giacobini P, Liu X, Chang YH, Ambudkar IS, Barker JL.

J Neurosci. 2005 Mar 9;25(10):2687-701.


FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway.

Zhou W, Feng X, Wu Y, Benge J, Zhang Z, Chen Z.

Cell Res. 2009 Oct;19(10):1165-77. doi: 10.1038/cr.2009.95. Epub 2009 Aug 4.


The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells.

Cross MJ, Lu L, Magnusson P, Nyqvist D, Holmqvist K, Welsh M, Claesson-Welsh L.

Mol Biol Cell. 2002 Aug;13(8):2881-93.


Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma.

Emmenegger BA, Hwang EI, Moore C, Markant SL, Brun SN, Dutton JW, Read TA, Fogarty MP, Singh AR, Durden DL, Yang C, McKeehan WL, Wechsler-Reya RJ.

Oncogene. 2013 Aug 29;32(35):4181-8. doi: 10.1038/onc.2012.440. Epub 2012 Oct 8.


Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models.

Issa A, Gill JW, Heideman MR, Sahin O, Wiemann S, Dey JH, Hynes NE.

Breast Cancer Res. 2013 Jan 23;15(1):R8. doi: 10.1186/bcr3379.


Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis.

Dey JH, Bianchi F, Voshol J, Bonenfant D, Oakeley EJ, Hynes NE.

Cancer Res. 2010 May 15;70(10):4151-62. doi: 10.1158/0008-5472.CAN-09-4479. Epub 2010 May 11.


Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk.

Matise LA, Palmer TD, Ashby WJ, Nashabi A, Chytil A, Aakre M, Pickup MW, Gorska AE, Zijlstra A, Moses HL.

Breast Cancer Res. 2012 Jul 2;14(4):R98. doi: 10.1186/bcr3217.


Feedback Activation of Basic Fibroblast Growth Factor Signaling via the Wnt/β-Catenin Pathway in Skin Fibroblasts.

Wang X, Zhu Y, Sun C, Wang T, Shen Y, Cai W, Sun J, Chi L, Wang H, Song N, Niu C, Shen J, Cong W, Zhu Z, Xuan Y, Li X, Jin L.

Front Pharmacol. 2017 Feb 3;8:32. doi: 10.3389/fphar.2017.00032. eCollection 2017.


FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review).

Katoh M.

Int J Mol Med. 2016 Jul;38(1):3-15. doi: 10.3892/ijmm.2016.2620. Epub 2016 May 31. Review.

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