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Serum sodium, model for end-stage liver disease, and a recent invasive procedure are risk factors for severe acute-on-chronic liver failure and death in cirrhotic patients hospitalized with bacterial infection.

Lopes-Secundo TM, Sevá-Pereira T, Correa BR, Silva NCM, Imbrizi MR, Cunha-Silva M, Soares EC, Almeida JRS. Lopes-Secundo TM, et al. Eur J Gastroenterol Hepatol. 2018 Sep;30(9):1055-1059. doi: 10.1097/MEG.0000000000001184. Eur J Gastroenterol Hepatol. 2018. PMID: 29944488

Serum Levels of Metabolites Produced by Intestinal Microbes and Lipid Moieties Independently Associated With Acute-on-Chronic Liver Failure and Death in Patients With Cirrhosis.

Bajaj JS, Reddy KR, O'Leary JG, Vargas HE, Lai JC, Kamath PS, Tandon P, Wong F, Subramanian RM, Thuluvath P, Fagan A, White MB, Gavis EA, Sehrawat T, de la Rosa Rodriguez R, Thacker LR, Sikaroodi M, Garcia-Tsao G, Gillevet PM. Bajaj JS, et al. Gastroenterology. 2020 Nov;159(5):1715-1730.e12. doi: 10.1053/j.gastro.2020.07.019. Epub 2020 Jul 17. Gastroenterology. 2020. PMID: 32687928 Free PMC article.

Chronic Liver Failure-Sequential Organ Failure Assessment is better than the Asia-Pacific Association for the Study of Liver criteria for defining acute-on-chronic liver failure and predicting outcome.

Dhiman RK, Agrawal S, Gupta T, Duseja A, Chawla Y. Dhiman RK, et al. World J Gastroenterol. 2014 Oct 28;20(40):14934-41. doi: 10.3748/wjg.v20.i40.14934. World J Gastroenterol. 2014. PMID: 25356054 Free PMC article.

Bacterial infection-triggered acute-on-chronic liver failure is associated with increased mortality.

Mücke MM, Rumyantseva T, Mücke VT, Schwarzkopf K, Joshi S, Kempf VAJ, Welsch C, Zeuzem S, Lange CM. Mücke MM, et al. Liver Int. 2018 Apr;38(4):645-653. doi: 10.1111/liv.13568. Epub 2017 Sep 15. Liver Int. 2018. PMID: 28853199

Combination and sequential evaluation of acute-on-chronic liver failure (ACLF) and hyponatremia and prognosis in cirrhotic patients.

Pereira G, Baldin C, Piedade J, Reis V, Valdeolivas T, Victor L, Guimarães L, Duarte J, Veiga Z, Alcântara C, Fernandes F, Pereira JL. Pereira G, et al. Dig Liver Dis. 2020 Jan;52(1):91-97. doi: 10.1016/j.dld.2019.08.013. Epub 2019 Sep 19. Dig Liver Dis. 2020. PMID: 31542220

Chronic liver failure-consortium acute-on-chronic liver failure and acute decompensation scores predict mortality in Brazilian cirrhotic patients.

Picon RV, Bertol FS, Tovo CV, de Mattos ÂZ. Picon RV, et al. World J Gastroenterol. 2017 Jul 28;23(28):5237-5245. doi: 10.3748/wjg.v23.i28.5237. World J Gastroenterol. 2017. PMID: 28811718 Free PMC article.

Fibroblast growth factor 21 is an early predictor of acute-on-chronic liver failure in critically ill patients with cirrhosis.

Ruiz-Margáin A, Pohlmann A, Ryan P, Schierwagen R, Chi-Cervera LA, Jansen C, Mendez-Guerrero O, Flores-García NC, Lehmann J, Torre A, Macías-Rodríguez RU, Trebicka J. Ruiz-Margáin A, et al. Liver Transpl. 2018 May;24(5):595-605. doi: 10.1002/lt.25041. Epub 2018 Apr 6. Liver Transpl. 2018. PMID: 29476704

Child-Pugh, MELD, and ALBI scores for predicting the in-hospital mortality in cirrhotic patients with acute-on-chronic liver failure.

Peng Y, Qi X, Tang S, Deng H, Li J, Ning Z, Dai J, Hou F, Zhao J, Wang R, Guo X. Peng Y, et al. Expert Rev Gastroenterol Hepatol. 2016 Aug;10(8):971-80. doi: 10.1080/17474124.2016.1177788. Epub 2016 Apr 25. Expert Rev Gastroenterol Hepatol. 2016. PMID: 27070325

Predictors of mortality among patients with compensated and decompensated liver cirrhosis: the role of bacterial infections and infection-related acute-on-chronic liver failure.

Sargenti K, Prytz H, Nilsson E, Kalaitzakis E. Sargenti K, et al. Scand J Gastroenterol. 2015 Jul;50(7):875-83. doi: 10.3109/00365521.2015.1017834. Epub 2015 Feb 19. Scand J Gastroenterol. 2015. PMID: 25697824

Model for end-stage liver disease-sodium underestimates 90-day mortality risk in patients with acute-on-chronic liver failure.

Hernaez R, Liu Y, Kramer JR, Rana A, El-Serag HB, Kanwal F. Hernaez R, et al. J Hepatol. 2020 Dec;73(6):1425-1433. doi: 10.1016/j.jhep.2020.06.005. Epub 2020 Jun 10. J Hepatol. 2020. PMID: 32531416 Free PMC article.

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