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Items: 1 to 20 of 103


Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex.

Wu M, Hayward D, Kalin JH, Song Y, Schwabe JW, Cole PA.

Elife. 2018 Jun 5;7. pii: e37231. doi: 10.7554/eLife.37231.


Human histone demethylase LSD1 reads the histone code.

Forneris F, Binda C, Vanoni MA, Battaglioli E, Mattevi A.

J Biol Chem. 2005 Dec 16;280(50):41360-5. Epub 2005 Oct 13.


LSD1 Substrate Binding and Gene Expression Are Affected by HDAC1-Mediated Deacetylation.

Nalawansha DA, Pflum MK.

ACS Chem Biol. 2017 Jan 20;12(1):254-264. doi: 10.1021/acschembio.6b00776. Epub 2016 Dec 15.


An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation.

Lee MG, Wynder C, Cooch N, Shiekhattar R.

Nature. 2005 Sep 15;437(7057):432-5. Epub 2005 Aug 3.


Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation.

Pilotto S, Speranzini V, Tortorici M, Durand D, Fish A, Valente S, Forneris F, Mai A, Sixma TK, Vachette P, Mattevi A.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2752-7. doi: 10.1073/pnas.1419468112. Epub 2015 Feb 17.


LSD1 regulates pluripotency of embryonic stem/carcinoma cells through histone deacetylase 1-mediated deacetylation of histone H4 at lysine 16.

Yin F, Lan R, Zhang X, Zhu L, Chen F, Xu Z, Liu Y, Ye T, Sun H, Lu F, Zhang H.

Mol Cell Biol. 2014 Jan;34(2):158-79. doi: 10.1128/MCB.00631-13. Epub 2013 Nov 4.


Posttranslational modifications of the histone 3 tail and their impact on the activity of histone lysine demethylases in vitro.

Lohse B, Helgstrand C, Kristensen JB, Leurs U, Cloos PA, Kristensen JL, Clausen RP.

PLoS One. 2013 Jul 2;8(7):e67653. doi: 10.1371/journal.pone.0067653. Print 2013.


Extranucleosomal DNA enhances the activity of the LSD1/CoREST histone demethylase complex.

Kim SA, Chatterjee N, Jennings MJ, Bartholomew B, Tan S.

Nucleic Acids Res. 2015 May 26;43(10):4868-80. doi: 10.1093/nar/gkv388. Epub 2015 Apr 27.


Lysine-specific demethylase 1 (LSD1) and histone deacetylase 1 (HDAC1) synergistically repress proinflammatory cytokines and classical complement pathway components.

Janzer A, Lim S, Fronhoffs F, Niazy N, Buettner R, Kirfel J.

Biochem Biophys Res Commun. 2012 May 18;421(4):665-70. doi: 10.1016/j.bbrc.2012.04.057. Epub 2012 Apr 17.


LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition.

Baron R, Vellore NA.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12509-14. doi: 10.1073/pnas.1207892109. Epub 2012 Jul 16.


Chemically Sumoylated Histone H4 Stimulates Intranucleosomal Demethylation by the LSD1-CoREST Complex.

Dhall A, Weller CE, Chu A, Shelton PMM, Chatterjee C.

ACS Chem Biol. 2017 Sep 15;12(9):2275-2280. doi: 10.1021/acschembio.7b00716. Epub 2017 Aug 30.


NuA4 links methylation of histone H3 lysines 4 and 36 to acetylation of histones H4 and H3.

Ginsburg DS, Anlembom TE, Wang J, Patel SR, Li B, Hinnebusch AG.

J Biol Chem. 2014 Nov 21;289(47):32656-70. doi: 10.1074/jbc.M114.585588. Epub 2014 Oct 9.


Histone Deacetylase 1 (HDAC1) Negatively Regulates Thermogenic Program in Brown Adipocytes via Coordinated Regulation of Histone H3 Lysine 27 (H3K27) Deacetylation and Methylation.

Li F, Wu R, Cui X, Zha L, Yu L, Shi H, Xue B.

J Biol Chem. 2016 Feb 26;291(9):4523-36. doi: 10.1074/jbc.M115.677930. Epub 2016 Jan 5.


The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines.

Murray-Stewart T, Woster PM, Casero RA Jr.

Amino Acids. 2014 Mar;46(3):585-94. doi: 10.1007/s00726-013-1485-1. Epub 2013 Mar 19.


The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code.

Fish JE, Matouk CC, Rachlis A, Lin S, Tai SC, D'Abreo C, Marsden PA.

J Biol Chem. 2005 Jul 1;280(26):24824-38. Epub 2005 May 3.


Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2.

Toffolo E, Rusconi F, Paganini L, Tortorici M, Pilotto S, Heise C, Verpelli C, Tedeschi G, Maffioli E, Sala C, Mattevi A, Battaglioli E.

J Neurochem. 2014 Mar;128(5):603-16. doi: 10.1111/jnc.12457. Epub 2013 Oct 23.


Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex.

Baron R, Binda C, Tortorici M, McCammon JA, Mattevi A.

Structure. 2011 Feb 9;19(2):212-20. doi: 10.1016/j.str.2011.01.001.


Expression, Purification, and Biochemical Analysis of the LSD1/KDM1A Histone Demethylase.

Laurent B, Shi Y.

Methods Enzymol. 2016;573:241-59. doi: 10.1016/bs.mie.2016.02.001. Epub 2016 Mar 4.


Epigenetic landscape of amphetamine and methamphetamine addiction in rodents.

Godino A, Jayanthi S, Cadet JL.

Epigenetics. 2015;10(7):574-80. doi: 10.1080/15592294.2015.1055441. Review.


Inhibitors of enzymes catalyzing modifications to histone lysine residues: structure, function and activity.

Lillico R, Stesco N, Khorshid Amhad T, Cortes C, Namaka MP, Lakowski TM.

Future Med Chem. 2016 May;8(8):879-97. doi: 10.4155/fmc-2016-0021. Epub 2016 May 13. Review.


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