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Items: 1 to 20 of 94

1.

Epigenetic Modifications of the α-Synuclein Gene and Relative Protein Content Are Affected by Ageing and Physical Exercise in Blood from Healthy Subjects.

Daniele S, Costa B, Pietrobono D, Giacomelli C, Iofrida C, Trincavelli ML, Fusi J, Franzoni F, Martini C.

Oxid Med Cell Longev. 2018 Apr 15;2018:3740345. doi: 10.1155/2018/3740345. eCollection 2018.

2.

Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson's disease.

Guhathakurta S, Evangelista BA, Ghosh S, Basu S, Kim YS.

Mol Brain. 2017 Feb 7;10(1):6. doi: 10.1186/s13041-017-0285-z.

3.

DNA methylation levels of α-synuclein intron 1 in the aging brain.

de Boni L, Riedel L, Schmitt I, Kraus TFJ, Kaut O, Piston D, Akbarian S, Wüllner U.

Neurobiol Aging. 2015 Dec;36(12):3334.e7-3334.e11. doi: 10.1016/j.neurobiolaging.2015.08.028. Epub 2015 Sep 8.

PMID:
26422361
4.

α-Synuclein Aggregates with β-Amyloid or Tau in Human Red Blood Cells: Correlation with Antioxidant Capability and Physical Exercise in Human Healthy Subjects.

Daniele S, Pietrobono D, Fusi J, Iofrida C, Chico L, Petrozzi L, Gerfo AL, Baldacci F, Galetta F, Siciliano G, Bonuccelli U, Santoro G, Trincavelli ML, Franzoni F, Martini C.

Mol Neurobiol. 2018 Mar;55(3):2653-2675. doi: 10.1007/s12035-017-0523-5. Epub 2017 Apr 18.

PMID:
28421539
5.

Deregulation of α-synuclein in Parkinson's disease: Insight from epigenetic structure and transcriptional regulation of SNCA.

Guhathakurta S, Bok E, Evangelista BA, Kim YS.

Prog Neurobiol. 2017 Jul;154:21-36. doi: 10.1016/j.pneurobio.2017.04.004. Epub 2017 Apr 23. Review.

6.

Epigenetic approach to early-onset Parkinson's disease: low methylation status of SNCA and PARK2 promoter regions.

Eryilmaz IE, Cecener G, Erer S, Egeli U, Tunca B, Zarifoglu M, Elibol B, Bora Tokcaer A, Saka E, Demirkiran M, Akbostanci C, Dogu O, Colakoglu B, Kenangil G, Kaleagasi H.

Neurol Res. 2017 Nov;39(11):965-972. doi: 10.1080/01616412.2017.1368141. Epub 2017 Aug 22.

PMID:
28830306
7.

DNA methylation in Parkinson's disease.

Wüllner U, Kaut O, deBoni L, Piston D, Schmitt I.

J Neurochem. 2016 Oct;139 Suppl 1:108-120. doi: 10.1111/jnc.13646. Epub 2016 Jun 10. Review.

8.

Variant in the 3' region of SNCA associated with Parkinson's disease and serum α-synuclein levels.

Hu Y, Tang B, Guo J, Wu X, Sun Q, Shi C, Hu L, Wang C, Wang L, Tan L, Shen L, Yan X, Zhang H.

J Neurol. 2012 Mar;259(3):497-504. doi: 10.1007/s00415-011-6209-4. Epub 2011 Aug 19.

PMID:
21853288
9.

L-dopa increases α-synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro.

Schmitt I, Kaut O, Khazneh H, deBoni L, Ahmad A, Berg D, Klein C, Fröhlich H, Wüllner U.

Mov Disord. 2015 Nov;30(13):1794-801. doi: 10.1002/mds.26319. Epub 2015 Jul 14.

PMID:
26173746
10.

Influence of physical exercise on β-amyloid, α-synuclein and tau accumulation: an in vitro model of oxidative stress in human red blood cells.

Iofrida C, Daniele S, Pietrobono D, Fusi J, Galetta F, Trincavelli ML, Bonuccelli U, Franzoni F, Martini C.

Arch Ital Biol. 2017 Jul 1;155(1-2):33-42. doi: 10.12871/000398292017124.

PMID:
28715596
11.

Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases.

Desplats P, Spencer B, Coffee E, Patel P, Michael S, Patrick C, Adame A, Rockenstein E, Masliah E.

J Biol Chem. 2011 Mar 18;286(11):9031-7. doi: 10.1074/jbc.C110.212589. Epub 2011 Feb 4.

12.

Methylation of α-synuclein and leucine-rich repeat kinase 2 in leukocyte DNA of Parkinson's disease patients.

Tan YY, Wu L, Zhao ZB, Wang Y, Xiao Q, Liu J, Wang G, Ma JF, Chen SD.

Parkinsonism Relat Disord. 2014 Mar;20(3):308-13. doi: 10.1016/j.parkreldis.2013.12.002. Epub 2013 Dec 16.

PMID:
24398085
13.

Epigenetic upregulation of alpha-synuclein in the rats exposed to methamphetamine.

Jiang W, Li J, Zhang Z, Wang H, Wang Z.

Eur J Pharmacol. 2014 Dec 15;745:243-8. doi: 10.1016/j.ejphar.2014.10.043. Epub 2014 Nov 5.

PMID:
25445041
14.

Parkinson's disease correlates with promoter methylation in the α-synuclein gene.

Pihlstrøm L, Berge V, Rengmark A, Toft M.

Mov Disord. 2015 Apr;30(4):577-80. doi: 10.1002/mds.26073. Epub 2014 Dec 27.

PMID:
25545759
15.

Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain.

Fuchs J, Tichopad A, Golub Y, Munz M, Schweitzer KJ, Wolf B, Berg D, Mueller JC, Gasser T.

FASEB J. 2008 May;22(5):1327-34. Epub 2007 Dec 27.

PMID:
18162487
16.

Next-generation sequencing reveals regional differences of the α-synuclein methylation state independent of Lewy body disease.

de Boni L, Tierling S, Roeber S, Walter J, Giese A, Kretzschmar HA.

Neuromolecular Med. 2011 Dec;13(4):310-20. doi: 10.1007/s12017-011-8163-9. Epub 2011 Nov 1.

PMID:
22042430
17.

Alpha-synuclein transcript isoforms in three different brain regions from Parkinson's disease and healthy subjects in relation to the SNCA rs356165/rs11931074 polymorphisms.

Cardo LF, Coto E, de Mena L, Ribacoba R, Mata IF, Menéndez M, Moris G, Alvarez V.

Neurosci Lett. 2014 Mar 6;562:45-9. doi: 10.1016/j.neulet.2014.01.009. Epub 2014 Jan 10.

PMID:
24418406
18.

Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson's disease patients.

Kang W, Chen W, Yang Q, Zhang L, Zhang L, Wang X, Dong F, Zhao Y, Chen S, Quinn TJ, Zhang J, Chen S, Liu J.

Sci Rep. 2016 Jun 23;6:28143. doi: 10.1038/srep28143.

19.

Allelic imbalance of expression and epigenetic regulation within the alpha-synuclein wild-type and p.Ala53Thr alleles in Parkinson disease.

Voutsinas GE, Stavrou EF, Karousos G, Dasoula A, Papachatzopoulou A, Syrrou M, Verkerk AJ, van der Spek P, Patrinos GP, Stöger R, Athanassiadou A.

Hum Mutat. 2010 Jun;31(6):685-91. doi: 10.1002/humu.21248.

PMID:
20340137
20.

Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease.

Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, Selkoe DJ, Oakes D, Shoulson I, Dong X, Marek K, Zheng B, Ivinson A, Hyman BT, Growdon JH, Sudarsky LR, Schlossmacher MG, Ravina B, Scherzer CR.

Brain. 2015 Sep;138(Pt 9):2659-71. doi: 10.1093/brain/awv202. Epub 2015 Jul 28.

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