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Items: 1 to 20 of 86

1.

Sirtuin 1 activation attenuates cardiac fibrosis in a rodent pressure overload model by modifying Smad2/3 transactivation.

Bugyei-Twum A, Ford C, Civitarese R, Seegobin J, Advani SL, Desjardins JF, Kabir G, Zhang Y, Mitchell M, Switzer J, Thai K, Shen V, Abadeh A, Singh KK, Billia F, Advani A, Gilbert RE, Connelly KA.

Cardiovasc Res. 2018 Oct 1;114(12):1629-1641. doi: 10.1093/cvr/cvy131.

PMID:
29800064
2.

Astaxanthin attenuated pressure overload-induced cardiac dysfunction and myocardial fibrosis: Partially by activating SIRT1.

Zhang J, Wang QZ, Zhao SH, Ji X, Qiu J, Wang J, Zhou Y, Cai Q, Zhang J, Gao HQ.

Biochim Biophys Acta Gen Subj. 2017 Jul;1861(7):1715-1728. doi: 10.1016/j.bbagen.2017.03.007. Epub 2017 Mar 12.

PMID:
28300638
3.

BMP-7 attenuates left ventricular remodelling under pressure overload and facilitates reverse remodelling and functional recovery.

Merino D, Villar AV, García R, Tramullas M, Ruiz L, Ribas C, Cabezudo S, Nistal JF, Hurlé MA.

Cardiovasc Res. 2016 Jun 1;110(3):331-45. doi: 10.1093/cvr/cvw076. Epub 2016 Apr 11.

PMID:
27068510
4.

Acetazolamide attenuates cardiac fibrosis induced by aortic constriction through inhibiting transforming growth factor-β1/Smad2 signaling pathway in mice.

Huo Q, Wang T, Wang T, Zhang R.

Exp Ther Med. 2019 Mar;17(3):2317-2321. doi: 10.3892/etm.2019.7210. Epub 2019 Jan 28.

5.

p-SMAD2/3 and DICER promote pre-miR-21 processing during pressure overload-associated myocardial remodeling.

García R, Nistal JF, Merino D, Price NL, Fernández-Hernando C, Beaumont J, González A, Hurlé MA, Villar AV.

Biochim Biophys Acta. 2015 Jul;1852(7):1520-30. doi: 10.1016/j.bbadis.2015.04.006. Epub 2015 Apr 15.

6.

The Sirt1 activator, SRT1720, attenuates renal fibrosis by inhibiting CTGF and oxidative stress.

Ren Y, Du C, Shi Y, Wei J, Wu H, Cui H.

Int J Mol Med. 2017 May;39(5):1317-1324. doi: 10.3892/ijmm.2017.2931. Epub 2017 Mar 22.

PMID:
28339034
7.

Velvet antler peptide prevents pressure overload-induced cardiac fibrosis via transforming growth factor (TGF)-β1 pathway inhibition.

Zhao L, Mi Y, Guan H, Xu Y, Mei Y.

Eur J Pharmacol. 2016 Jul 15;783:33-46. doi: 10.1016/j.ejphar.2016.04.039. Epub 2016 Apr 21.

PMID:
27108788
8.

Transforming growth factor-β inhibits myocardial PPARγ expression in pressure overload-induced cardiac fibrosis and remodeling in mice.

Gong K, Chen YF, Li P, Lucas JA, Hage FG, Yang Q, Nozell SE, Oparil S, Xing D.

J Hypertens. 2011 Sep;29(9):1810-9. doi: 10.1097/HJH.0b013e32834a4d03.

9.

Sirtuin 1 Activation Reduces Transforming Growth Factor-β1-Induced Fibrogenesis and Affords Organ Protection in a Model of Progressive, Experimental Kidney and Associated Cardiac Disease.

Zhang Y, Connelly KA, Thai K, Wu X, Kapus A, Kepecs D, Gilbert RE.

Am J Pathol. 2017 Jan;187(1):80-90. doi: 10.1016/j.ajpath.2016.09.016.

PMID:
27993241
10.

High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy.

Bugyei-Twum A, Advani A, Advani SL, Zhang Y, Thai K, Kelly DJ, Connelly KA.

Cardiovasc Diabetol. 2014 May 5;13:89. doi: 10.1186/1475-2840-13-89.

11.

Stachydrine ameliorates pressure overload-induced diastolic heart failure by suppressing myocardial fibrosis.

Chen HH, Zhao P, Zhao WX, Tian J, Guo W, Xu M, Zhang C, Lu R.

Am J Transl Res. 2017 Sep 15;9(9):4250-4260. eCollection 2017.

12.

Up-regulation of BMP-2 antagonizes TGF-β1/ROCK-enhanced cardiac fibrotic signalling through activation of Smurf1/Smad6 complex.

Wang S, Sun A, Li L, Zhao G, Jia J, Wang K, Ge J, Zou Y.

J Cell Mol Med. 2012 Oct;16(10):2301-10. doi: 10.1111/j.1582-4934.2012.01538.x.

13.

Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5.

Engebretsen KV, Skårdal K, Bjørnstad S, Marstein HS, Skrbic B, Sjaastad I, Christensen G, Bjørnstad JL, Tønnessen T.

J Mol Cell Cardiol. 2014 Nov;76:148-57. doi: 10.1016/j.yjmcc.2014.08.008. Epub 2014 Aug 26.

PMID:
25169971
14.

Ablation of biglycan attenuates cardiac hypertrophy and fibrosis after left ventricular pressure overload.

Beetz N, Rommel C, Schnick T, Neumann E, Lother A, Monroy-Ordonez EB, Zeeb M, Preissl S, Gilsbach R, Melchior-Becker A, Rylski B, Stoll M, Schaefer L, Beyersdorf F, Stiller B, Hein L.

J Mol Cell Cardiol. 2016 Dec;101:145-155. doi: 10.1016/j.yjmcc.2016.10.011. Epub 2016 Oct 24.

PMID:
27789290
15.

Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway.

Xiao H, Ma X, Feng W, Fu Y, Lu Z, Xu M, Shen Q, Zhu Y, Zhang Y.

Cardiovasc Res. 2010 Aug 1;87(3):504-13. doi: 10.1093/cvr/cvq066. Epub 2010 Mar 3.

PMID:
20200042
16.

Heat shock transcription factor 1 protects against pressure overload-induced cardiac fibrosis via Smad3.

Zhou N, Ye Y, Wang X, Ma B, Wu J, Li L, Wang L, Wang DW, Zou Y.

J Mol Med (Berl). 2017 Apr;95(4):445-460. doi: 10.1007/s00109-016-1504-2. Epub 2017 Jan 13.

17.

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis through inhibition of transforming growth factor β-induced Smad signaling.

Gong W, Yan M, Chen J, Chaugai S, Chen C, Wang D.

Front Med. 2014 Dec;8(4):445-55. doi: 10.1007/s11684-014-0378-3. Epub 2014 Nov 22.

PMID:
25416030
18.

Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction.

Maizel J, Xavier S, Chen J, Lin CH, Vasko R, Goligorsky MS.

Am J Physiol Heart Circ Physiol. 2014 Dec 15;307(12):H1691-704. doi: 10.1152/ajpheart.00281.2014. Epub 2014 Sep 19.

19.

Buyanghuanwu Decoction alleviated pressure overload induced cardiac remodeling by suppressing Tgf-β/Smads and MAPKs signaling activated fibrosis.

Chen H, Song H, Liu X, Tian J, Tang W, Cao T, Zhao P, Zhang C, Guo W, Xu M, Lu R.

Biomed Pharmacother. 2017 Nov;95:461-468. doi: 10.1016/j.biopha.2017.08.102. Epub 2017 Sep 12.

PMID:
28865366
20.

Induced NCX1 overexpression attenuates pressure overload-induced pathological cardiac remodelling.

Ujihara Y, Iwasaki K, Takatsu S, Hashimoto K, Naruse K, Mohri S, Katanosaka Y.

Cardiovasc Res. 2016 Sep;111(4):348-61. doi: 10.1093/cvr/cvw113. Epub 2016 May 26.

PMID:
27229460

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