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Items: 1 to 20 of 102

1.

Comprehensive analysis of the mouse cytochrome P450 family responsible for omega-3 epoxidation of eicosapentaenoic acid.

Isobe Y, Itagaki M, Ito Y, Naoe S, Kojima K, Ikeguchi M, Arita M.

Sci Rep. 2018 May 21;8(1):7954. doi: 10.1038/s41598-018-26325-4.

2.

Cytochrome P450-dependent metabolism of omega-6 and omega-3 long-chain polyunsaturated fatty acids.

Arnold C, Konkel A, Fischer R, Schunck WH.

Pharmacol Rep. 2010 May-Jun;62(3):536-47. Review.

3.

Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production.

Harmon SD, Fang X, Kaduce TL, Hu S, Raj Gopal V, Falck JR, Spector AA.

Prostaglandins Leukot Essent Fatty Acids. 2006 Sep;75(3):169-77. Epub 2006 Jul 3.

PMID:
16820285
4.

Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily.

Barbosa-Sicard E, Markovic M, Honeck H, Christ B, Muller DN, Schunck WH.

Biochem Biophys Res Commun. 2005 Apr 22;329(4):1275-81.

PMID:
15766564
5.

Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids.

Arnold C, Markovic M, Blossey K, Wallukat G, Fischer R, Dechend R, Konkel A, von Schacky C, Luft FC, Muller DN, Rothe M, Schunck WH.

J Biol Chem. 2010 Oct 22;285(43):32720-33. doi: 10.1074/jbc.M110.118406. Epub 2010 Aug 23.

6.

Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases.

Schunck WH, Konkel A, Fischer R, Weylandt KH.

Pharmacol Ther. 2018 Mar;183:177-204. doi: 10.1016/j.pharmthera.2017.10.016. Epub 2017 Nov 7. Review.

PMID:
29080699
7.

Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway.

Fischer R, Konkel A, Mehling H, Blossey K, Gapelyuk A, Wessel N, von Schacky C, Dechend R, Muller DN, Rothe M, Luft FC, Weylandt K, Schunck WH.

J Lipid Res. 2014 Jun;55(6):1150-64. doi: 10.1194/jlr.M047357. Epub 2014 Mar 16.

8.

Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.

Lucas D, Goulitquer S, Marienhagen J, Fer M, Dreano Y, Schwaneberg U, Amet Y, Corcos L.

J Lipid Res. 2010 May;51(5):1125-33. doi: 10.1194/jlr.M003061. Epub 2009 Nov 25.

9.

Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids.

Konkel A, Schunck WH.

Biochim Biophys Acta. 2011 Jan;1814(1):210-22. doi: 10.1016/j.bbapap.2010.09.009. Epub 2010 Sep 30.

PMID:
20869469
10.

Cytochrome P450-generated metabolites derived from ω-3 fatty acids attenuate neovascularization.

Yanai R, Mulki L, Hasegawa E, Takeuchi K, Sweigard H, Suzuki J, Gaissert P, Vavvas DG, Sonoda KH, Rothe M, Schunck WH, Miller JW, Connor KM.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9603-8. doi: 10.1073/pnas.1401191111. Epub 2014 Jun 16.

11.

Anti-inflammatory ω-3 endocannabinoid epoxides.

McDougle DR, Watson JE, Abdeen AA, Adili R, Caputo MP, Krapf JE, Johnson RW, Kilian KA, Holinstat M, Das A.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6034-E6043. doi: 10.1073/pnas.1610325114. Epub 2017 Jul 7.

12.

Fungal cytochrome P450 monooxygenases of Fusarium oxysporum for the synthesis of ω-hydroxy fatty acids in engineered Saccharomyces cerevisiae.

Durairaj P, Malla S, Nadarajan SP, Lee PG, Jung E, Park HH, Kim BG, Yun H.

Microb Cell Fact. 2015 Apr 2;14:45. doi: 10.1186/s12934-015-0228-2.

13.

Whatever happened to the epoxyeicosatrienoic Acid-like endothelium-derived hyperpolarizing factor? The identification of novel classes of lipid mediators and their role in vascular homeostasis.

Frömel T, Fleming I.

Antioxid Redox Signal. 2015 May 10;22(14):1273-92. doi: 10.1089/ars.2014.6150. Epub 2014 Dec 4. Review.

PMID:
25330284
15.

Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: highly stereoselective formation of 17(R),18(S)-epoxyeicosatetraenoic acid.

Schwarz D, Kisselev P, Ericksen SS, Szklarz GD, Chernogolov A, Honeck H, Schunck WH, Roots I.

Biochem Pharmacol. 2004 Apr 15;67(8):1445-57.

PMID:
15041462
16.

CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease?

Westphal C, Konkel A, Schunck WH.

Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):99-108. doi: 10.1016/j.prostaglandins.2011.09.001. Epub 2011 Sep 16. Review.

PMID:
21945326
17.

Metabolism of eicosapentaenoic and docosahexaenoic acids by recombinant human cytochromes P450.

Fer M, Dréano Y, Lucas D, Corcos L, Salaün JP, Berthou F, Amet Y.

Arch Biochem Biophys. 2008 Mar 15;471(2):116-25. doi: 10.1016/j.abb.2008.01.002. Epub 2008 Jan 11.

PMID:
18206980
18.

Cytochrome P450-derived eicosanoids and heart function.

Jamieson KL, Endo T, Darwesh AM, Samokhvalov V, Seubert JM.

Pharmacol Ther. 2017 Nov;179:47-83. doi: 10.1016/j.pharmthera.2017.05.005. Epub 2017 May 25. Review.

PMID:
28551025
19.

Eicosapentaenoic acid is converted via ω-3 epoxygenation to the anti-inflammatory metabolite 12-hydroxy-17,18-epoxyeicosatetraenoic acid.

Kubota T, Arita M, Isobe Y, Iwamoto R, Goto T, Yoshioka T, Urabe D, Inoue M, Arai H.

FASEB J. 2014 Feb;28(2):586-93. doi: 10.1096/fj.13-236224. Epub 2013 Oct 15.

PMID:
24128889
20.

Cytochrome P450-dependent metabolism of eicosapentaenoic acid in the nematode Caenorhabditis elegans.

Kulas J, Schmidt C, Rothe M, Schunck WH, Menzel R.

Arch Biochem Biophys. 2008 Apr 1;472(1):65-75. doi: 10.1016/j.abb.2008.02.002. Epub 2008 Feb 8.

PMID:
18282462

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