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Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators.

Hommel B, Mukaremera L, Cordero RJB, Coelho C, Desjardins CA, Sturny-Leclère A, Janbon G, Perfect JR, Fraser JA, Casadevall A, Cuomo CA, Dromer F, Nielsen K, Alanio A.

PLoS Pathog. 2018 May 18;14(5):e1006982. doi: 10.1371/journal.ppat.1006982. eCollection 2018 May.


The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis.

Dambuza IM, Drake T, Chapuis A, Zhou X, Correia J, Taylor-Smith L, LeGrave N, Rasmussen T, Fisher MC, Bicanic T, Harrison TS, Jaspars M, May RC, Brown GD, Yuecel R, MacCallum DM, Ballou ER.

PLoS Pathog. 2018 May 18;14(5):e1006978. doi: 10.1371/journal.ppat.1006978. eCollection 2018 May.


Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals.

Trevijano-Contador N, de Oliveira HC, García-Rodas R, Rossi SA, Llorente I, Zaballos Á, Janbon G, Ariño J, Zaragoza Ó.

PLoS Pathog. 2018 May 18;14(5):e1007007. doi: 10.1371/journal.ppat.1007007. eCollection 2018 May.


DNA mutations mediate microevolution between host-adapted forms of the pathogenic fungus Cryptococcus neoformans.

Magditch DA, Liu TB, Xue C, Idnurm A.

PLoS Pathog. 2012;8(10):e1002936. doi: 10.1371/journal.ppat.1002936. Epub 2012 Oct 4.


Polyploid titan cells produce haploid and aneuploid progeny to promote stress adaptation.

Gerstein AC, Fu MS, Mukaremera L, Li Z, Ormerod KL, Fraser JA, Berman J, Nielsen K.

MBio. 2015 Oct 13;6(5):e01340-15. doi: 10.1128/mBio.01340-15.


The formation of titan cells in Cryptococcus neoformans depends on the mouse strain and correlates with induction of Th2-type responses.

García-Barbazán I, Trevijano-Contador N, Rueda C, de Andrés B, Pérez-Tavárez R, Herrero-Fernández I, Gaspar ML, Zaragoza O.

Cell Microbiol. 2016 Jan;18(1):111-24. doi: 10.1111/cmi.12488. Epub 2015 Sep 6.


Titan cell production enhances the virulence of Cryptococcus neoformans.

Crabtree JN, Okagaki LH, Wiesner DL, Strain AK, Nielsen JN, Nielsen K.

Infect Immun. 2012 Nov;80(11):3776-85. doi: 10.1128/IAI.00507-12. Epub 2012 Aug 13.


Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli.

Okagaki LH, Wang Y, Ballou ER, O'Meara TR, Bahn YS, Alspaugh JA, Xue C, Nielsen K.

Eukaryot Cell. 2011 Oct;10(10):1306-16. doi: 10.1128/EC.05179-11. Epub 2011 Aug 5.


Titan cells confer protection from phagocytosis in Cryptococcus neoformans infections.

Okagaki LH, Nielsen K.

Eukaryot Cell. 2012 Jun;11(6):820-6. doi: 10.1128/EC.00121-12. Epub 2012 Apr 27.


Quorum sensing-mediated, cell density-dependent regulation of growth and virulence in Cryptococcus neoformans.

Albuquerque P, Nicola AM, Nieves E, Paes HC, Williamson PR, Silva-Pereira I, Casadevall A.

MBio. 2013 Dec 31;5(1):e00986-13. doi: 10.1128/mBio.00986-13.


Titan cells in Cryptococcus neoformans: cells with a giant impact.

Zaragoza O, Nielsen K.

Curr Opin Microbiol. 2013 Aug;16(4):409-13. doi: 10.1016/j.mib.2013.03.006. Epub 2013 Apr 12.


Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses.

O'Meara TR, Holmer SM, Selvig K, Dietrich F, Alspaugh JA.

MBio. 2013 Jan 15;4(1). pii: e00522-12. doi: 10.1128/mBio.00522-12.


Regulated expression of cyclic AMP-dependent protein kinase A reveals an influence on cell size and the secretion of virulence factors in Cryptococcus neoformans.

Choi J, Vogl AW, Kronstad JW.

Mol Microbiol. 2012 Aug;85(4):700-15. doi: 10.1111/j.1365-2958.2012.08134.x. Epub 2012 Jul 13.


The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans.

Attarian R, Hu G, Sánchez-León E, Caza M, Croll D, Do E, Bach H, Missall T, Lodge J, Jung WH, Kronstad JW.

MBio. 2018 Dec 4;9(6). pii: e02377-18. doi: 10.1128/mBio.02377-18. Erratum in: MBio. 2019 Apr 30;10(2):.


Fungal cell gigantism during mammalian infection.

Zaragoza O, García-Rodas R, Nosanchuk JD, Cuenca-Estrella M, Rodríguez-Tudela JL, Casadevall A.

PLoS Pathog. 2010 Jun 17;6(6):e1000945. doi: 10.1371/journal.ppat.1000945. Erratum in: PLoS Pathog. 2010;6(6). doi: 10.1371/annotation/0675044c-d80f-456f-bb63-4f85fb1d0c33.


Mismatch Repair of DNA Replication Errors Contributes to Microevolution in the Pathogenic Fungus Cryptococcus neoformans.

Boyce KJ, Wang Y, Verma S, Shakya VPS, Xue C, Idnurm A.

MBio. 2017 May 30;8(3). pii: e00595-17. doi: 10.1128/mBio.00595-17.


Phenotypic Variability Correlates with Clinical Outcome in Cryptococcus Isolates Obtained from Botswanan HIV/AIDS Patients.

Fernandes KE, Brockway A, Haverkamp M, Cuomo CA, van Ogtrop F, Perfect JR, Carter DA.

MBio. 2018 Oct 23;9(5). pii: e02016-18. doi: 10.1128/mBio.02016-18.


Clinicopathological features of pulmonary cryptococcosis with cryptococcal titan cells: a comparative analysis of 27 cases.

Wang JM, Zhou Q, Cai HR, Zhuang Y, Zhang YF, Xin XY, Meng FQ, Wang YP.

Int J Clin Exp Pathol. 2014 Jul 15;7(8):4837-46. eCollection 2014.


Computational Analysis Reveals a Key Regulator of Cryptococcal Virulence and Determinant of Host Response.

Gish SR, Maier EJ, Haynes BC, Santiago-Tirado FH, Srikanta DL, Ma CZ, Li LX, Williams M, Crouch EC, Khader SA, Brent MR, Doering TL.

MBio. 2016 Apr 19;7(2):e00313-16. doi: 10.1128/mBio.00313-16.


Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule.

O'Meara TR, Norton D, Price MS, Hay C, Clements MF, Nichols CB, Alspaugh JA.

PLoS Pathog. 2010 Feb 19;6(2):e1000776. doi: 10.1371/journal.ppat.1000776.

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