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Distinguishing mirtrons from canonical miRNAs with data exploration and machine learning methods.

Rorbach G, Unold O, Konopka BM.

Sci Rep. 2018 May 15;8(1):7560. doi: 10.1038/s41598-018-25578-3.


Comparing miRNA structure of mirtrons and non-mirtrons.

Titov II, Vorozheykin PS.

BMC Genomics. 2018 Feb 9;19(Suppl 3):114. doi: 10.1186/s12864-018-4473-8.


Analysis of Nearly One Thousand Mammalian Mirtrons Reveals Novel Features of Dicer Substrates.

Wen J, Ladewig E, Shenker S, Mohammed J, Lai EC.

PLoS Comput Biol. 2015 Sep 1;11(9):e1004441. doi: 10.1371/journal.pcbi.1004441. eCollection 2015 Sep.


Biogenesis of mammalian microRNAs by a non-canonical processing pathway.

Havens MA, Reich AA, Duelli DM, Hastings ML.

Nucleic Acids Res. 2012 May;40(10):4626-40. doi: 10.1093/nar/gks026. Epub 2012 Jan 23.


The biogenesis and characterization of mammalian microRNAs of mirtron origin.

Sibley CR, Seow Y, Saayman S, Dijkstra KK, El Andaloussi S, Weinberg MS, Wood MJ.

Nucleic Acids Res. 2012 Jan;40(1):438-48. doi: 10.1093/nar/gkr722. Epub 2011 Sep 13.


Splicing-dependent expression of microRNAs of mirtron origin in human digestive and excretory system cancer cells.

Butkytė S, Čiupas L, Jakubauskienė E, Vilys L, Mocevicius P, Kanopka A, Vilkaitis G.

Clin Epigenetics. 2016 Mar 25;8:33. doi: 10.1186/s13148-016-0200-y. eCollection 2016.


Intronic microRNA precursors that bypass Drosha processing.

Ruby JG, Jan CH, Bartel DP.

Nature. 2007 Jul 5;448(7149):83-6. Epub 2007 Jun 24.


Identification of mirtrons in rice using MirtronPred: a tool for predicting plant mirtrons.

Joshi PK, Gupta D, Nandal UK, Khan Y, Mukherjee SK, Sanan-Mishra N.

Genomics. 2012 Jun;99(6):370-5. doi: 10.1016/j.ygeno.2012.04.002. Epub 2012 Apr 21.


Mammalian mirtron genes.

Berezikov E, Chung WJ, Willis J, Cuppen E, Lai EC.

Mol Cell. 2007 Oct 26;28(2):328-36.


Functional VEGFA knockdown with artificial 3'-tailed mirtrons defined by 5' splice site and branch point.

Kock KH, Kong KW, Hoon S, Seow Y.

Nucleic Acids Res. 2015 Jul 27;43(13):6568-78. doi: 10.1093/nar/gkv617. Epub 2015 Jun 18.


Mirtrons: microRNA biogenesis via splicing.

Westholm JO, Lai EC.

Biochimie. 2011 Nov;93(11):1897-904. doi: 10.1016/j.biochi.2011.06.017. Epub 2011 Jun 21. Review.


Computational and experimental identification of mirtrons in Drosophila melanogaster and Caenorhabditis elegans.

Chung WJ, Agius P, Westholm JO, Chen M, Okamura K, Robine N, Leslie CS, Lai EC.

Genome Res. 2011 Feb;21(2):286-300. doi: 10.1101/gr.113050.110. Epub 2010 Dec 22.


Nucleotide-level Convolutional Neural Networks for Pre-miRNA Classification.

Zheng X, Xu S, Zhang Y, Huang X.

Sci Rep. 2019 Jan 24;9(1):628. doi: 10.1038/s41598-018-36946-4.


Discovery of hundreds of mirtrons in mouse and human small RNA data.

Ladewig E, Okamura K, Flynt AS, Westholm JO, Lai EC.

Genome Res. 2012 Sep;22(9):1634-45. doi: 10.1101/gr.133553.111.


Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor.

Bortolamiol-Becet D, Hu F, Jee D, Wen J, Okamura K, Lin CJ, Ameres SL, Lai EC.

Mol Cell. 2015 Jul 16;59(2):217-28. doi: 10.1016/j.molcel.2015.05.034. Epub 2015 Jul 2.


MicroRNA biogenesis via splicing and exosome-mediated trimming in Drosophila.

Flynt AS, Greimann JC, Chung WJ, Lima CD, Lai EC.

Mol Cell. 2010 Jun 25;38(6):900-7. doi: 10.1016/j.molcel.2010.06.014.


The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila.

Okamura K, Hagen JW, Duan H, Tyler DM, Lai EC.

Cell. 2007 Jul 13;130(1):89-100. Epub 2007 Jun 28.


Experimental validation of predicted mammalian microRNAs of mirtron origin.

Schamberger A, Orbán TI.

Methods Mol Biol. 2014;1182:245-63. doi: 10.1007/978-1-4939-1062-5_22.


Human mirtrons can express functional microRNAs simultaneously from both arms in a flanking exon-independent manner.

Schamberger A, Sarkadi B, Orban TI.

RNA Biol. 2012 Sep;9(9):1177-85. doi: 10.4161/rna.21359. Epub 2012 Sep 1.


The long and short of inverted repeat genes in animals: microRNAs, mirtrons and hairpin RNAs.

Okamura K, Chung WJ, Lai EC.

Cell Cycle. 2008 Sep 15;7(18):2840-5. Epub 2008 Sep 5. Review.

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