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Theoretical Insights into the Retinal Dynamics of Vascular Endothelial Growth Factor in Patients Treated with Ranibizumab, Based on an Ocular Pharmacokinetic/Pharmacodynamic Model.

Hutton-Smith LA, Gaffney EA, Byrne HM, Caruso A, Maini PK, Mazer NA. Hutton-Smith LA, et al. Mol Pharm. 2018 Jul 2;15(7):2770-2784. doi: 10.1021/acs.molpharmaceut.8b00280. Epub 2018 May 29. Mol Pharm. 2018. PMID: 29734810

A Mechanistic Model of the Intravitreal Pharmacokinetics of Large Molecules and the Pharmacodynamic Suppression of Ocular Vascular Endothelial Growth Factor Levels by Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration.

Hutton-Smith LA, Gaffney EA, Byrne HM, Maini PK, Schwab D, Mazer NA. Hutton-Smith LA, et al. Mol Pharm. 2016 Sep 6;13(9):2941-50. doi: 10.1021/acs.molpharmaceut.5b00849. Epub 2016 Jan 14. Mol Pharm. 2016. PMID: 26726925

Vascular endothelial growth factor in patients with exudative age-related macular degeneration treated with ranibizumab.

Muether PS, Hermann MM, Viebahn U, Kirchhof B, Fauser S. Muether PS, et al. Ophthalmology. 2012 Oct;119(10):2082-6. doi: 10.1016/j.ophtha.2012.07.041. Epub 2012 Aug 22. Ophthalmology. 2012. PMID: 22920670

A model of the ocular pharmacokinetics involved in the therapy of neovascular age-related macular degeneration with ranibizumab.

Saunders DJ, Muether PS, Fauser S. Saunders DJ, et al. Br J Ophthalmol. 2015 Nov;99(11):1554-9. doi: 10.1136/bjophthalmol-2015-306771. Epub 2015 May 8. Br J Ophthalmol. 2015. PMID: 25957377

Long-term stability of vascular endothelial growth factor suppression time under ranibizumab treatment in age-related macular degeneration.

Muether PS, Hermann MM, Dröge K, Kirchhof B, Fauser S. Muether PS, et al. Am J Ophthalmol. 2013 Nov;156(5):989-993.e2. doi: 10.1016/j.ajo.2013.06.020. Epub 2013 Aug 12. Am J Ophthalmol. 2013. PMID: 23938122

Retinal and choroidal thickness changes after single anti-VEGF injection in neovascular age-related macular degeneration: ranibizumab vs bevacizumab.

Sizmaz S, Kucukerdonmez C, Kal A, Pinarci EY, Canan H, Yilmaz G. Sizmaz S, et al. Eur J Ophthalmol. 2014 Nov-Dec;24(6):904-10. doi: 10.5301/ejo.5000478. Epub 2014 May 5. Eur J Ophthalmol. 2014. PMID: 24803153 Clinical Trial.

Vitreomacular Interface after Anti-Vascular Endothelial Growth Factor Injections in Neovascular Age-Related Macular Degeneration.

Veloso CE, Kanadani TM, Pereira FB, Nehemy MB. Veloso CE, et al. Ophthalmology. 2015 Aug;122(8):1569-72. doi: 10.1016/j.ophtha.2015.04.028. Epub 2015 May 30. Ophthalmology. 2015. PMID: 26038338

Cytokine and Chemokine Profile Changes in Patients with Neovascular Age-Related Macular Degeneration After Intravitreal Ranibizumab Injection for Choroidal Neovascularization.

Sun T, Wei Q, Gao P, Zhang Y, Peng Q. Sun T, et al. Drug Des Devel Ther. 2021 Jun 9;15:2457-2467. doi: 10.2147/DDDT.S307657. eCollection 2021. Drug Des Devel Ther. 2021. PMID: 34140764 Free PMC article.

Effect of posterior vitreous detachment on aqueous humor level of vascular endothelial growth factor in exudative age-related macular degeneration patients.

Nomura Y, Takahashi H, Tan X, Fujino Y, Kawashima H, Yanagi Y. Nomura Y, et al. Graefes Arch Clin Exp Ophthalmol. 2016 Jan;254(1):53-7. doi: 10.1007/s00417-015-3006-2. Epub 2015 Apr 12. Graefes Arch Clin Exp Ophthalmol. 2016. PMID: 25863675

Neovascular age-related macular degeneration: intraocular cytokines and growth factors and the influence of therapy with ranibizumab.

Funk M, Karl D, Georgopoulos M, Benesch T, Sacu S, Polak K, Zlabinger GJ, Schmidt-Erfurth U. Funk M, et al. Ophthalmology. 2009 Dec;116(12):2393-9. doi: 10.1016/j.ophtha.2009.05.039. Epub 2009 Oct 7. Ophthalmology. 2009. PMID: 19815292 Clinical Trial.

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