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Items: 1 to 20 of 101


Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering.

Cai H, Muller J, Depoil D, Mayya V, Sheetz MP, Dustin ML, Wind SJ.

Nat Nanotechnol. 2018 Jul;13(7):610-617. doi: 10.1038/s41565-018-0113-3. Epub 2018 Apr 30.


High-Affinity Ligands Can Trigger T Cell Receptor Signaling Without CD45 Segregation.

Al-Aghbar MA, Chu YS, Chen BM, Roffler SR.

Front Immunol. 2018 Apr 9;9:713. doi: 10.3389/fimmu.2018.00713. eCollection 2018.


In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase.

Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9338-E9345. doi: 10.1073/pnas.1710358114. Epub 2017 Oct 17.


Initiation of T cell signaling by CD45 segregation at 'close contacts'.

Chang VT, Fernandes RA, Ganzinger KA, Lee SF, Siebold C, McColl J, Jönsson P, Palayret M, Harlos K, Coles CH, Jones EY, Lui Y, Huang E, Gilbert RJC, Klenerman D, Aricescu AR, Davis SJ.

Nat Immunol. 2016 May;17(5):574-582. doi: 10.1038/ni.3392. Epub 2016 Mar 21.


T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.

Choudhuri K, Wiseman D, Brown MH, Gould K, van der Merwe PA.

Nature. 2005 Jul 28;436(7050):578-82.


Phosphatase CD45 both positively and negatively regulates T cell receptor phosphorylation in reconstituted membrane protein clusters.

Furlan G, Minowa T, Hanagata N, Kataoka-Hamai C, Kaizuka Y.

J Biol Chem. 2014 Oct 10;289(41):28514-25. doi: 10.1074/jbc.M114.574319. Epub 2014 Aug 15.


Rescue of signaling by a chimeric protein containing the cytoplasmic domain of CD45.

Hovis RR, Donovan JA, Musci MA, Motto DG, Goldman FD, Ross SE, Koretzky GA.

Science. 1993 Apr 23;260(5107):544-6.


T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters.

Manz BN, Jackson BL, Petit RS, Dustin ML, Groves J.

Proc Natl Acad Sci U S A. 2011 May 31;108(22):9089-94. doi: 10.1073/pnas.1018771108. Epub 2011 May 16.


TCR-mediated adhesion of T cell hybridomas to planar bilayers containing purified MHC class II/peptide complexes and receptor shedding during detachment.

Dustin ML, Miller JM, Ranganath S, Vignali DA, Viner NJ, Nelson CA, Unanue ER.

J Immunol. 1996 Sep 1;157(5):2014-21.


Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge.

Majeti R, Bilwes AM, Noel JP, Hunter T, Weiss A.

Science. 1998 Jan 2;279(5347):88-91.


A TIRF microscopy technique for real-time, simultaneous imaging of the TCR and its associated signaling proteins.

Crites TJ, Chen L, Varma R.

J Vis Exp. 2012 Mar 22;(61). pii: 3892. doi: 10.3791/3892.


Self-aligned supported lipid bilayers for patterning the cell-substrate interface.

Shen K, Tsai J, Shi P, Kam LC.

J Am Chem Soc. 2009 Sep 23;131(37):13204-5. doi: 10.1021/ja904721h.


Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination.

Pielak RM, O'Donoghue GP, Lin JJ, Alfieri KN, Fay NC, Low-Nam ST, Groves JT.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12190-12195. doi: 10.1073/pnas.1613140114. Epub 2017 Oct 30.


CD45 tyrosine phosphatase activity and membrane anchoring are required for T-cell antigen receptor signaling.

Niklinska BB, Hou D, June C, Weissman AM, Ashwell JD.

Mol Cell Biol. 1994 Dec;14(12):8078-84.


A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination.

Taylor MJ, Husain K, Gartner ZJ, Mayor S, Vale RD.

Cell. 2017 Mar 23;169(1):108-119.e20. doi: 10.1016/j.cell.2017.03.006.


The T cell receptor triggering apparatus is composed of monovalent or monomeric proteins.

James JR, McColl J, Oliveira MI, Dunne PD, Huang E, Jansson A, Nilsson P, Sleep DL, Gonçalves CM, Morgan SH, Felce JH, Mahen R, Fernandes RA, Carmo AM, Klenerman D, Davis SJ.

J Biol Chem. 2011 Sep 16;286(37):31993-2001. doi: 10.1074/jbc.M111.219212. Epub 2011 Jul 13.

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